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Severe corneal toxicity after
topical fluoroquinolone therapy: report of two cases.
Comparative evaluation of
possible ocular photochemical toxicity of fluoroquinolones meant for
ocular use in experimental models. Velpandian T, Bankoti R, Humayun S,
Ravi AK, Kumari SS, Biswas NR.
Corneal deposits and topical
ofloxacin-the effect of polypharmacy in the management of microbial
keratitis. Mitra A, Tsesmetzoglou E, McElvanney A.
Corneal deposits and topical
ofloxacin
In vitro effects of
fluoroquinolone and aminoglycoside antibiotics on human
keratocytes. Leonardi A, Papa V, Fregona I, Russo P, De Franchis G,
Milazzo G. Department of Neuroscience, Ophthalmology Unit, University
of Padova, Italy.
[Corneal precipitation of fluoroquinolones
with magnesium] [Article in French] Parent X, Marchal A, Patillon JC.
Service de biochimie, Centre hospitalier Pasteur, Colmar.
xavier.parent@ch-colmar.rss.fr
Phototoxic lesions induced by quinolone
antibacterial agents in auricular skin and retina of albino mice.
Sparfloxacin
corneal deposits
Apoptotic photoreceptor cell death induced
by quinolone phototoxicity in mice.
Sparfloxacin concentration in the
iris-ciliary body was significantly higher in the pigmented rat's eyes
rather than in the albino rat's eyes.
Comparative assessment of ocular tissue
distribution of drug-related radioactivity after chronic oral
administration of 14C-levofloxacin and 14C-chloroquine in pigmented
rats.
Optometrists may encounter patients
treated with either chloroquine (CQ) or hydroxychloroquine (HCQ).
These drugs are quinolones, and have been known to cause irreversible
retinal toxicity.
Non-abating
vision damage associated with the use of the fluoroquinolones.
Fluoroquinolone Toxicity Research Foundation
June 2004
Corneal Intrastromal Gatifloxacin Crystal
Deposits After Penetrating Keratoplasty.
UVA-induced oxidative damage in
retinal pigment epithelial cells after H2O2 or sparfloxacin exposure.
Behçet disease
is a systemic disorder characterized by recurrent aphthous ulcers and
intraocular inflammation
Chloroquine
and hydroxychloroquine belong to the quinolone family
Chemicals that
damage its proteins and membranes or radiation that breaks its DNA
molecules, that cell can just stop functioning
OCUFLOX®
ophthalmic solution ADVERSE REACTIONS
Evaluation and
Management of Monocular Diplopia
Fluoroquinolone Effective In Treating Corneal Ulcer But Should Be Used
With Caution
Peripheral
sensory disturbances related to treatment with fluoroquinolones
Reversible
visual loss in a patient receiving high-dose ciprofloxacin
hydrochloride (Cipro)
Enrofloxacin-associated
retinal degeneration in cats
Ophthalmotoxicity and ototoxicity of the new quinolone antibacterial
agent levofloxacin in Long Evans rats
Factors
affecting visual loss in benign intracranial hypertension
Dystrophy,
Map-dot-fingerprint excerpt
Bayer Agriculture Division Animal Health
"Dear Doctor" letter, circa 2000, regarding vision loss and
veterinarian usage
Pure Cipro
found in the human cornea:
Ciprofloxacin microprecipitates and
macroprecipitates in the human corneal epithelium. Eiferman RA, Snyder
JP, Nordquist RE.
Quotes from various Adverse Reaction Forums
regarding vision damage
Quotes from Medications.com Levaquin Adverse Reaction Forum
regarding vision damage
Effect of topical fluoroquinolones on the
expression of matrix metalloproteinases in the cornea. Reviglio VE,
Hakim MA, Song JK, O'Brien TP.
Evaluation of the
corneal effects of topical ophthalmic fluoroquinolones using in vivo
confocal microscopy.
An in vivo study comparing the ocular
absorption of levofloxacin and ciprofloxacin prior to
phacoemulsification.
Quinolone toxicity: methods of
assessment.
Phototoxic retinal degeneration
and toxicokinetics of sitafloxacin, a quinolone antibacterial agent,
in miceAn in vivo
study comparing the ocular absorption of levofloxacin and
ciprofloxacin prior to phacoemulsification. Am J Ophthalmol 2004
Feb;137(2):308-12 (ISSN: 0002-9394) Bucci FA Bucci Laser Vision,
Wilkes-Barre, Pennsylvania, USA. Buccivision@aol.com.
Eye Contact Lens. 2004 Apr;30(2):90-4. Related Articles, Links
Evaluation of the corneal effects of topical ophthalmic
fluoroquinolones using in vivo confocal microscopy. Kovoor TA, Kim AS,
McCulley JP, Cavanagh HD, Jester JV, Bugde AC, Petroll WM. University
of Texas Southwestern Medical School, University of Texas Southwestern
Medical Center, Dallas, TX, USA.
Additional articles of interest
Additional Links from PubMed/Medline
1
Pinilla I, Perez-Olivan S, Solans C, Bregante MA, Ramirez MT, Larrosa JM, Pablo
LE, Honrubia FM.Histological toxicity of grepafloxacin after
intravitreal injection.
Ophthalmic Res. 2003 Nov-Dec;35(6):335-40.
PMID: 14688424 [PubMed - indexed for MEDLINE]
2
Tanaka M, Takashina H, Tsutsumi S.Comparative assessment of ocular
tissue distribution of drug-related radioactivity after chronic oral
administration of 14C-levofloxacin and 14C-chloroquine in pigmented rats.
J Pharm Pharmacol. 2004 Aug;56(8):977-83.
PMID: 15285841 [PubMed - in process]
3
Kovoor TA, Kim AS, McCulley JP, Cavanagh HD, Jester JV, Bugde AC, Petroll WM.Evaluation
of the corneal effects of topical ophthalmic fluoroquinolones using in vivo
confocal microscopy.
Eye Contact Lens. 2004 Apr;30(2):90-4.
PMID: 15260356 [PubMed - indexed for MEDLINE]
4
Gokhale NS.Sparfloxacin corneal deposits.
Indian J Ophthalmol. 2004 Mar;52(1):79. No abstract available.
PMID: 15132389 [PubMed - indexed for MEDLINE]
5
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epithelium on the intraocular penetration of fluoroquinolone ophthalmic
solution.
Jpn J Ophthalmol. 2004 Mar-Apr;48(2):93-6.
PMID: 15060787 [PubMed - indexed for MEDLINE]
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Ng EW, Joo MJ, Eong KG, Green WR, O'Brien TP.Ocular toxicity of
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Curr Eye Res. 2003 Dec;27(6):387-93.
PMID: 14704922 [PubMed - indexed for MEDLINE]
7
Reviglio VE, Hakim MA, Song JK, O'Brien TP.Effect of topical
fluoroquinolones on the expression of matrix metalloproteinases in the cornea.
BMC Ophthalmol. 2003 Oct 06;3(1):10.
PMID: 14529574 [PubMed - in process]
8
Boeve MH.[Fluoroquinolone-related blindness in cats]
Tijdschr Diergeneeskd. 2003 Oct 1;128(19):600. Dutch. No
abstract available.
PMID: 14582324 [PubMed - indexed for MEDLINE]
9
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ulcers]
Antibiot Khimioter. 2003;48(6):16-9. Russian.
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cats.
J Am Vet Med Assoc. 2002 Dec 1;221(11):1568-71. Review.
PMID: 12479325 [PubMed - indexed for MEDLINE]
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Wilson D.Feline visual changes associated with enrofloxacin.
Can Vet J. 2002 Mar;43(3):163. No abstract available.
PMID: 11901587 [PubMed - indexed for MEDLINE]
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J Am Vet Med Assoc. 2001 Dec 15;219(12):1676. No abstract
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13
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Arch Toxicol. 2001 Sep;75(7):395-9.
PMID: 11693179 [PubMed - indexed for MEDLINE]
14
Gelatt KN, van der Woerdt A, Ketring KL, Andrew SE, Brooks DE, Biros DJ, Denis
HM, Cutler TJ.Enrofloxacin-associated retinal degeneration in cats.
Vet Ophthalmol. 2001 Jun;4(2):99-106. Erratum in: Vet Ophthalmol
2001 Sep;4(3):231.
PMID: 11422990 [PubMed - indexed for MEDLINE]
15
Mallari PL, McCarty DJ, Daniell M, Taylor H.Increased incidence of
corneal perforation after topical fluoroquinolone treatment for microbial
keratitis.
Am J Ophthalmol. 2001 Jan;131(1):131-3.
PMID: 11162991 [PubMed - indexed for MEDLINE]
16
Lomaestro BM.Fluoroquinolone-induced renal failure.
Drug Saf. 2000 Jun;22(6):479-85. Review.
PMID: 10877041 [PubMed - indexed for MEDLINE]
17
Castillo A, Benitez del Castillo JM, Toledano N, Diaz-Valle D, Sayagues O,
Garcia-Sanchez J.Deposits of topical norfloxacin in the treatment of
bacterial keratitis.
Cornea. 1997 Jul;16(4):420-3.
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18
Watson PM.Idiosyncratic reaction to enrofloxacin in cats.
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mura M, Nishida T, Mishima H, Otori T.Effects of
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21
Portoles M, Igual A, Jauch A, Nos-Barbera S.In vitro
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22
Sirbat D, Saudax E, Hurault de Ligny B, Hachet E, Raspiller A.[Serous
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23
Pouzaud F, Rat P, Cambourieu C, Nourry H, Warnet JM.[Tenotoxic
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24
Healy DP, Holland EJ, Nordlund ML, Dunn S, Chow C, Lindstrom RL, Hardten D,
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25 Awwad ST, Wang MX, Cavanagh HD. Related Articles, Links
A case of gatifloxacin crystal deposits in the corneal graft of an 85-year-old
man.
Eye Contact Lens. 2006 May;32(3):157. No abstract available.
PMID: 16702872 [PubMed - indexed for MEDLINE]
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