The Fluoroquinolone Toxicity Research Foundation

 

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 [Corneal precipitation of fluoroquinolones with magnesium]

[Article in French]

Parent X, Marchal A, Patillon JC.

Service de biochimie, Centre hospitalier Pasteur, Colmar. xavier.parent@ch-colmar.rss.fr

Infrared spectrophotometric analysis (FTIR) was performed on a crystalline deposit developed in a corneal ulcer by an old woman who received ciprofloxacine ophthalmic drops. We collected the data of the literature on the subject. After in vitro crystallization experiments, we conclude that ciprofloxacin and norfloxacin corneal precipitates occur at physiological lachrymal pH with magnesium. Shokuhin Eiseigaku Zasshi. 2004 Oct;45(5):239-44. Related Articles, Links