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| The Fluoroquinolone
Toxicity Research Foundation
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Vision Research | See downloads for: Adobe Files |
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Ciprofloxacin microprecipitates and macroprecipitates in the human corneal epithelium. Eiferman RA, Snyder JP, Nordquist RE. Research Service, Veterans Administration Medical Center, Louisville, Kentucky, USA. reiferman@cs.com In 4 corneal transplantation patients treated preoperatively with ciprofloxacin ophthalmic drops, microprecipitates associated with damaged corneal epithelium were noted in 2 patients. Another patient developed a large macroprecipitate in a corneal ulcer. All specimens were examined by electron microscopy and high-pressure liquid chromatography. The crystalline precipitates were pure ciprofloxacin. The macroprecipitate demonstrated a large zone of inhibition on agar plates seeded with a susceptible organism at 24 and 48 hours. It was bioactive and bioavailable in vitro.
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