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1.     Caffeine is able to penetrate the blood brain barrier and directly influence the
        CNS
          Lamarine (1994) notes caffeine is able to penetrate the blood brain barrier and directly influence
the CNS. Ochs, Holmes, and Karst (1992) report as a chemical, caffeine is a methylated
xanthine, a powerful central nervous system (CNS) stimulant which can arouse all levels of the
rain and the skeletal muscles.

2.     Neurotoxic effects of the fluoroquinolones include insomnia, seizures,
       delirium, and psychosis.
The reported neurotoxic effects of the fluoroquinolones include insomnia, seizures, delirium, and
psychosis, best explained by the gamma-aminobutyric acid-antagonistic properties of this class of
drugs. (quinolones are known as gaba inhibitors so have the ability to bind to  neurorecptor sites).