Case Report

Ciprofloxacin-Induced Toxic Epidermal Necrolysis in a Patient with Systemic Lupus Erythematosus

M. Jongen-Lavrencic1, P. M. Schneeberger2 and J. G. van der Hoeven3

(1) Dept. of Internal Medicine, Jeroen Bosch Ziekenhuis, s-Hertogenbosch, The Netherlands

(2) Dept. of Medical Microbiology, Jeroen Bosch Ziekenhuis, 90153, NL-5200 ME s-Hertogenbosch, The Netherlands

(3) Intensive Care Unit, Jeroen Bosch Ziekenhuis, s-Hertogenbosch, The Netherlands

Received: 15 September 2001 Accepted: 8 April 2003

Abstract. Toxic epidermal necrolysis (TEN), or Lyells syndrome, is a fulminant bullous dermatitis. TEN is often a drug-induced reaction and virtually any drug class appears capable of provoking it. We report here a case of TEN after administration of ciprofloxacin. Systemic lupus erythematosus (SLE) was suspected as a possible etiologic or modifying cofactor in TEN in this case.