A Long-Term Study of the Incidence of Musculoskeletal Disorders in Children Who Have Received Levofloxacin or a Standard Non-Fluoroquinone Therapy for Acute Bacterial Infection This study is no longer recruiting patients. Sponsored by: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells.
Sendzik J, Shakibaei M, Schafer-Korting M, Stahlmann R.

Levofloxacin-induced bilateral Achilles tendonitis Lewis JR, JG Gums, and DL Dickensheets 1999

Foot Ankle Int. 1996 Aug;17(8):496-8. 
Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review.

J Am Podiatr Med Assoc. 2003 Jul-Aug;93(4):333-5.
Fluoroquinolone therapy and Achilles tendon rupture.
Vanek D, Saxena A, Boggs JM.

Clin Rheumatol. 2003 Dec;22(6):500-1. Epub 2003 Oct 18.
Ciprofloxacin and Achilles' tendon rupture: a causal relationship.

Bilateral simultaneous spontaneous rupture of the Achilles tendon.
Mehra A, Maheshwari R, Case R, Croucher C.

Aten Primaria. 2003 Sep 15;32(4):256
Bilateral Achilles tendinitis as adverse reaction to levofloxacine.

Pharm World Sci. 2001 Jun;23(3):89-92.
Fluoroquinolone use and the change in incidence of tendon ruptures in the Netherlands.
van der Linden PD, Nab HW, Simonian S, Stricker BH, Leufkens HG, Herings RM.

Therapie. 2004 Nov-Dec;59(6):653-5.
Ofloxacin-induced achilles tendinitis in the absence of a predisposition

Rev Rhum Engl Ed. 1999 Jul-Sep;66(7-9):419-21.
Suspected role of ofloxacin in a case of arthalgia, myalgia, and multiple tendinopathy.

Therapie. 2003 Sep-Oct;58(5):463-5.
The myo-tendinopathy caused by levofloxacin

Reumatismo. 2003 Oct-Dec;55(4):267-9.
Levofloxacin-induced bilateral rupture of the Achilles tendon: clinical and sonographic findings

An Med Interna. 2004 Mar;21(3):154.
Achilles bilateral tendonitis and levofloxacin

J Orthop Sci. 2004;9(2):186-90.
Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.

Scand J Infect Dis. 2004;36(4):315-6.
Recurrent tendinitis after treatment with two different fluoroquinolones.

Rupture of multiple tendons after levofloxacin therapy.
Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, Trechot P.

Arch Orthop Trauma Surg. 2005 Mar;125(2):124-6. Epub 2005 Jan 12.
Missed Achilles tendon rupture due to oral levofloxacin: surgical treatment and result.

Infection. 2000 Jul-Aug;28(4):256-7.
Fluoroquinolone-induced tendinopathy: also occurring with levofloxacin.

Aten Primaria. 2004 Mar 15;33(4):214.
Muscle and tendon problems as a side-effect of levofloxacine: review of a case

Ann Pharmacother. 1999 Jul-Aug;33(7-8):792-5.
Levofloxacin-induced bilateral Achilles tendonitis.

Rev Clin Esp. 2001 Sep;201(9):539-40.
Achilles pain and functional impotence in a patient with chronic obstructive pulmonary disease with pneumonia. Tendon rupture caused by levofloxacin

Gastroenterol Hepatol. 2003 Jan;26(1):53-4.
Rupture of the Achilles' tendon secondary to levofloxacin

An Med Interna. 2005 Jan;22(1):28-30.
Partial bilateral rupture of the Achilles tendon associated to levofloxacin

Med Clin (Barc). 2003 Jan 25;120(2):78-9.
Comment on: Med Clin (Barc). 2002 Jun 8;119(1):38-9.
Levofloxacin and bilateral spontaneous Achilles tendon rupture

Rev Med Chil. 2002 Nov;130(11):1277-81.
Achilles tendinitis associated to levofloxacin: report of 4 cases

J Antimicrob Chemother. 2003 Mar;51(3):747-8.
Spontaneous Achilles tendon rupture in patients treated with levofloxacin.

Foot Ankle Int. 2003 Feb;24(2):122-4.
Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to levofloxacin.

Chemotherapy. 2003 May;49(1-2):90-1.
Reoccurrence of levofloxacin-induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?

Ann Pharmacother. 2003 Jul-Aug;37(7-8):1014-7.
Levofloxacin-associated Achilles tendon rupture.

Pharmacol Exp Ther. 2004 Jan;308(1):394-402. Epub 2003 Oct 20. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress.

Clin Rheumatol. 2003 Oct;22(4-5):367-8.
Bilateral Achilles tendinitis with spontaneous rupture induced by levofloxacin in a patient with systemic sclerosis.

Scand J Infect Dis. 2003;35(10):768-70.
Levofloxacin-associated Achilles tendon rupture and tendinopathy.

J Am Board Fam Pract. 2003 Sep-Oct;16(5):458-60.
Levofloxacin-induced tendon rupture: a case report and review of the literature.

Expert Opin Drug Saf. 2005 Mar;4(2):299-309.
Fluoroquinolones and tendon disorders.
Melhus A.

Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.   J Orthop Sci 2004;9(2):186-90 (ISSN: 0949-2658)  Kowatari K; Nakashima K; Ono A; Yoshihara M; Amano M; Toh S  Department of Orthopaedic Surgery, Aomori Rosai Hospital, 1 Minamigaoka, Shirogane-machi, Hachinohe 031-8551, Japan.

Levofloxacin-associated Achilles tendon rupture and tendinopathy.  Scand J Infect Dis 2003;35(10):768-70 (ISSN: 0036-5548)   Melhus A; Apelqvist J; Larsson J; Eneroth M   Department of Medical Microbiology, Malmo University Hospital, Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se.

Levofloxacin and trovafloxacin inhibition of experimental fracture-healing.   Clin Orthop 2003 Sep;(414):95-100 (ISSN: 0009-921X)   Perry AC; Prpa B; Rouse MS; Piper KE; Hanssen AD; Steckelberg JM; Patel R   Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Levofloxacin-associated Achilles tendon rupture. Ann Pharmacother 2003 Jul-Aug;37(7-8):1014-7 (ISSN: 1060-0280) Mathis AS; Chan V; Gryszkiewicz M; Adamson RT; Friedman GS  Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. smathis@sbhcs.com.

Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to levofloxacin.  Foot Ankle Int 2003 Feb;24(2):122-4 (ISSN: 1071-1007) Cebrian P; Manjon P; Caba P  Departamento de Radiodiagnostico, Hospital Universitario 12 de Octubre, Madrid, Spain. pcvbb@yahoo.es.

Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis
Tina Papastavros, Lisa R. Dolovich, Anne Holbrook, Lori Whitehead, and Mark Loeb

Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells.
Sendzik J, Shakibaei M, Schafer-Korting M, Stahlmann R.

Expert Opin Drug Saf. 2005 Mar;4(2):299-309.
Fluoroquinolones and tendon disorders.
Melhus A.
Lund University, Department of Medical Microbiology, Malmo University Hospital, S-205 02 Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se

Aten Primaria. 2005 Sep 30;36(5):286-7. [Tendinitis associated with levofloxacin] [Article in Spanish] Alvarez Luque I, Gomariz Santacecilia M, Villamor Baliarda E, Rando Matos Y, Garcia Fernandez Y.

Chondrotoxicity of quinolones in vivo and in vitro.  Hildebrand H, Kempka G, Schluter G, Schmidt M.  Bayer AG, Fachbereich Toxikologie, Pharma-Forschungszentrum, Wuppertal, Germany. 

Expert Opin Drug Saf. 2005 Mar;4(2):299-309. Fluoroquinolones and tendon disorders. Melhus A. Lund University, Department of Medical Microbiology, Malmo University Hospital, S-205 02 Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se

Rupture of multiple tendons after levofloxacin therapy. Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, Trechot P. Pneumology Department, Maillot Hospital, 54150 Briey, France.

A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin.

Tendon Rupture associated with fluoroquinolones / Animals Studies

Antibacterial quinolones induce joint cartilage lesions in juvenile animals at relatively low doses. They are therefore contraindicated in children and adolescents as well as in pregnant and lactating women.

Something must be wrong with the muscles of FM patients because they seemed to be the origin of so much pain and dysfunction.

Malic Acid: For Muscle Pain and Stiffness

Chronic Fatigue Syndrome (CFS), Fibromyalgia Syndrome (FMS) and Gulf War Illnesses (GWI)

Chronic Fatigue Syndrome / Fibromyalgia Syndrome (FMS) is a debilitating group of illnesses

Magnesium deficiency has an effect on multiple body functions.

Hypomagnesaemia: Is defined as an abnormally low serum magnesium level

Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance.

Physiopathology of symptomatic and latent forms of central nervous hyperexcitability due to magnesium deficiency: a current general scheme.

Magnesium

EMR Textbook - Neuromuscular Transmission Failure

The rate of magnesium absorption varies

Rupture of multiple tendons after levofloxacin therapy. Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, Trechot P. Pneumology Department, Maillot Hospital, 54150 Briey, France.

Fluoroquinolones are relatively safe, effective antibiotics. As their use becomes more frequent, so will the adverse side effects.

Persistent and chronic poly arthritis

The pharmacological management of drug-induced rheumatic disorders.

Conventional Arthritis treatments generally compromise by relieving physical symptoms only, which are secondary to a primary cause.

Regional Pain Syndromes: Diagnosis and Management

Ciprofloxacin-associated Achilles tendon rupture in a hemodialysis patient

Tendonitis is an inflammatory condition characterized by pain at tendinous insertions into bone.

Fluoroquinolones – tendinitis : update

Tendinitis and tendon rupture with fluoroquinolones

The Achilless heel of fluoroquinolones

The comparative arthropathy of fluoroquinolones in dogs

Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro

Fluoroquinolone's Effect on Growth of Human Chondrocytes and Chondrosarcomas: In Vitro and In Vivo Correlation

Repeated rupture of the extensor tendons of the hand due to fluoroquinolones. Apropos of a case

Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium-Deficient Diet

Fluoroquinolone-Induced Tendinopathy: What Do We Know?

Their potential role in routine use for paediatric patients will remain limited because of potential joint complications

Fluorine level in the bone and cartilage in children treated with ciprofloxacin

The effect of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism.

Fluoroquinolones in Pediatrics

Petition to Require a Warning on All Fluoroquinolone Antibiotics

Fluoroquinolones and Risk of Achilles Tendon Disorders

Spontaneous rupture of Achilles tendon and fluoroquinolones

Ciprofloxacin Inhibition of Experimental Fracture-Healing

Quinolone-associated tendonitis: a potential problem in COPD?

The Pathology & Healing of Tendinosis

One of the most common and pronounced adverse drug reactions to fluoroquinolones is often manifested as severe joint, muscle and tendon pain

Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.

Long term outcome after Fluoroquinolones tendinopathies
13/01/2004

In vitro discrimination of fluoroquinolones toxicity on tendon cells: Involvement of Oxidative Stress.

Reappraisal of quinolone tolerability. The experience of their musculoskeletal adverse effects.

Quinolone-Related Achilles Tendon Rupture Risk High in Elderly on Corticosteroids

Arthritis and other chronic joint problems are far more widespread than estimated just five years ago, affecting one in three U.S. adults, or 69.9 million people in all

Tendonitis associated with fluoroquinolones may be prolonged.

Medications-Impair-Shoulder-Healing

Quinolone toxicity: methods of assessment.

Ciprofloxacin reduces the stimulation of prostaglandin E₂ output by interleukin-1ß in human tendon-derived cells

In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress

1    Bringas Calvo R, Iglesias Cortinas D.
[Acute and bilateral uveitis secondary to moxifloxacin]
Arch Soc Esp Oftalmol. 2004 Jul;79(7):357-60. Spanish.
PMID: 15286907 [PubMed - in process

3    McKinley BT, Oglesby RJ.A 57-year-old male retired colonel with acute ankle swelling.
Mil Med. 2004 Mar;169(3):254-6. No abstract available.
PMID: 15080249 [PubMed - indexed for MEDLINE]

4    Kastner M, Rahm U, Baumann-Wilschke I, Bello A, Stahlmann R.Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats.
Arch Toxicol. 2004 Feb;78(2):61-7. Epub 2003 Dec 06.
PMID: 14661070 [PubMed - in process]

5    Kahn F, Christensson B.[A rapid development of Achilles tendon rupture following quinolone treatment]
Lakartidningen. 2004 Jan 15;101(3):190-1. Swedish. No abstract available.
PMID: 14763088 [PubMed - indexed for MEDLINE]

6    [No authors listed]Antibiotics: Achilles' heel of the Achilles' tendon.
Harv Health Lett. 2004 Jan;29(3):7. No abstract available.
PMID: 14734287 [PubMed - indexed for MEDLINE]

7    Pouzaud F, Bernard-Beaubois K, Thevenin M, Warnet JM, Hayem G, Rat P.In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress.
J Pharmacol Exp Ther. 2004 Jan;308(1):394-402. Epub 2003 Oct 20.
PMID: 14569066 [PubMed - indexed for MEDLINE]

8    Rodriguez-Vera FJ, Pereira Vega A, Pujol de la Llave E.[Tendinitis by quinolones: treatment and drug class effect in two new cases]
Rev Clin Esp. 2004 Jan;204(1):35-6. Spanish. No abstract available.
PMID: 14746761 [PubMed - indexed for MEDLINE]

9    Burkhardt O, Kohnlein T, Pap T, Welte T.Recurrent tendinitis after treatment with two different fluoroquinolones.
Scand J Infect Dis. 2004;36(4):315-6.
PMID: 15198194 [PubMed - indexed for MEDLINE]

10    Shah P.[Do tendon lesions occur during quinolone administration?]
Dtsch Med Wochenschr. 2003 Oct 17;128(42):2214. German. No abstract available.
PMID: 14562223 [PubMed - indexed for MEDLINE]

11    Shakibaei M, Stahlmann R.Ultrastructural changes induced by the des-F(6)-quinolone garenoxacin (BMS-284756) and two fluoStahlmann R.Children as a special population at risk--quinolones as an example for xenobiotics exhibiting skeletal toxicity.
Arch Toxicol. 2003 Jan;77(1):7-11. Epub 2002 Oct 26. Review.
PMID: 12491034 [PubMed - indexed for MEDLINE]roquinolones in Achilles tendon from immature rats.
Arch Toxicol. 2003 Sep;77(9):521-6. Epub 2003 Jun 17.
PMID: 12811465 [PubMed - indexed for MEDLINE]

21    Aros C, Flores C, Mezzano S.[Achilles tendinitis associated to levofloxacin: report of 4 cases]
Rev Med Chil. 2002 Nov;130(11):1277-81. Spanish.
PMID: 12587511 [PubMed - indexed for MEDLINE]

22    Nagai A, Miyazaki M, Morita T, Furubo S, Kizawa K, Fukumoto H, Sanzen T, Hayakawa H, Kawamura Y.Comparative articular toxicity of garenoxacin, a novel quinolone antimicrobial agent, in juvenile beagle dogs.
J Toxicol Sci. 2002 Aug;27(3):219-28.
PMID: 12238145 [PubMed - indexed for MEDLINE]

23    Lozo E, Riecke K, Schwabe R, Vormann J, Stahlmann R.Synergistic effect of ofloxacin and magnesium deficiency on joint cartilage in immature rats.
Antimicrob Agents Chemother. 2002 Jun;46(6):1755-9.
PMID: 12019086 [PubMed - indexed for MEDLINE]

24    van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HG, Stricker BH.Fluoroquinolones and risk of Achilles tendon disorders: case-control study.
BMJ. 2002 Jun 1;324(7349):1306-7. No abstract available.
PMID: 12039823 [PubMed - indexed for MEDLINE]

25    Yee CL, Duffy C, Gerbino PG, Stryker S, Noel GJ.Tendon or joint disorders in children after treatment with fluoroquinolones or azithromycin.
Pediatr Infect Dis J. 2002 Jun;21(6):525-9.
PMID: 12182376 [PubMed - indexed for MEDLINE]

26    Guis S, Bendahan D, Kozak-Ribbens G, Mattei JP, Le Fur Y, Confort-Gouny S, Figarella-Branger D, Jouglard J, Cozzone PJ.Investigation of fluoroquinolone-induced myalgia using (31)P magnetic resonance spectroscopy and in vitro contracture tests.
Arthritis Rheum. 2002 Mar;46(3):774-8.
PMID: 11920414 [PubMed - indexed for MEDLINE]

27    Postnikov SS, Semykin SIu, Nazhimov VP, Novichkova GA.[On fluoroquinolones treatment safety in children (clinical, morphological and catamnesis data)]
Antibiot Khimioter. 2002;47(9):14-7. Russian.
PMID: 12619515 [PubMed - indexed for MEDLINE]

28    Gendrel D.[Fluoroquinolones in children]
Med Trop (Mars). 2002;62(2):185-92. Review. French.
PMID: 12192718 [PubMed - indexed for MEDLINE]

29    Saint F, Salomon L, Cicco A, de la Taille A, Chopin D, Abbou CC.[Tendinopathy associated with fluoroquinolones: individuals at risk, incriminated physiopathologic mechanisms, therapeutic management]
Prog Urol. 2001 Dec;11(6):1331-4. Review. French.
PMID: 11859676 [PubMed - indexed for MEDLINE]

30    Danes I, Arnau JM.[Safety of quinolones administration in children?]
Med Clin (Barc). 2001 Nov 24;117(17):676-7. Spanish. No abstract available.
PMID: 11734174 [PubMed - indexed for MEDLINE]

31    Shakibaei M, de Souza P, van Sickle D, Stahlmann R.Biochemical changes in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding a magnesium-deficient diet.
Arch Toxicol. 2001 Aug;75(6):369-74.
PMID: 11570695 [PubMed - indexed for MEDLINE]

32    Butler MW, Griffin JF, Quinlan WR, McDonnell TJ.Quinolone-associated tendonitis: a potential problem in COPD?
Ir J Med Sci. 2001 Jul-Sep;170(3):198-9.
PMID: 12120977 [PubMed - indexed for MEDLINE]

33    van der Linden PD, van Puijenbroek EP, Feenstra J, Veld BA, Sturkenboom MC, Herings RM, Leufkens HG, Stricker BH.Tendon disorders attributed to fluoroquinolones: a study on 42 spontaneous reports in the period 1988 to 1998.
Arthritis Rheum. 2001 Jun;45(3):235-9.
PMID: 11409663 [PubMed - indexed for MEDLINE]

34    Davenport CL, Boston RC, Richardson DW.Effects of enrofloxacin and magnesium deficiency on matrix metabolism in equine articular cartilage.
Am J Vet Res. 2001 Feb;62(2):160-6.
PMID: 11212020 [PubMed - indexed for MEDLINE]

35    Postnikov CC, Semiakin SI, Nazhimov VP, Kapranov NI.[Comparative yearly growth rate of children with mucoviscidosis treated and not treated with ciprofloxacin:clinicomorphological comparisons]
Antibiot Khimioter. 2001;46(10):11-3. Russian.
PMID: 11881187 [PubMed - indexed for MEDLINE]

36    Gendrel D, Moulin F.Fluoroquinolones in paediatrics.
Paediatr Drugs. 2001;3(5):365-77. Review.
PMID: 11393329 [PubMed - indexed for MEDLINE]

37    Carrion Valero F, Facila Rubio L, Marin Pardo J.[Syncope after administration of moxifloxacin]
Arch Bronconeumol. 2000 Nov;36(10):603-4. Spanish. No abstract available.
PMID: 11149208 [PubMed - indexed for MEDLINE]

38    Saint F, Gueguen G, Biserte J, Fontaine C, Mazeman E.[Rupture of the patellar ligament one month after treatment with fluoroquinolone]
Rev Chir Orthop Reparatrice Appar Mot. 2000 Sep;86(5):495-7. French.
PMID: 10970974 [PubMed - indexed for MEDLINE]

39    Fanos V, Cuzzolin L.Fluoroquinolones in pediatrics and their nephrotoxicity in adults: minireview.
J Chemother. 2000 Jun;12(3):228-31. Review.
PMID: 10877518 [PubMed - indexed for MEDLINE]

40    Guzman A, Garcia C, Demestre I.Subchronic toxicity of the new quinolone antibacterial agent irloxacin in beagle dogs.
Arzneimittelforschung. 2000 May;50(5):485-94.
PMID: 10858877 [PubMed - indexed for MEDLINE]

41    Casparian JM, Luchi M, Moffat RE, Hinthorn D.Quinolones and tendon ruptures.
South Med J. 2000 May;93(5):488-91. Review.
PMID: 10832946 [PubMed - indexed for MEDLINE]

42    Simonin MA, Gegout-Pottie P, Minn A, Gillet P, Netter P, Terlain B.Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.
Antimicrob Agents Chemother. 2000 Apr;44(4):867-72.
PMID: 10722483 [PubMed - indexed for MEDLINE]

43    Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R.Ciprofloxacin inhibition of experimental fracture healing.
J Bone Joint Surg Am. 2000 Feb;82(2):161-73.
PMID: 10682725 [PubMed - indexed for MEDLINE]

44    Padeiskaia EN.[Arthrotoxicity of quinolones and fluoroquinolones in experiment:character of lesion and mechanism of action]
Antibiot Khimioter. 2000;45(8):36-41. Review. Russian. No abstract available.
PMID: 10989723 [PubMed - indexed for MEDLINE]

45    Stahlmann R, Kuhner S, Shakibaei M, Flores J, Vormann J, van Sickle DC.Effects of magnesium deficiency on joint cartilage in immature beagle dogs: immunohistochemistry, electron microscopy, and mineral concentrations.
Arch Toxicol. 2000 Jan;73(10-11):573-80.
PMID: 10663389 [PubMed - indexed for MEDLINE]

47    Egerbacher M, Seiberl G, Wolfesberger B, Walter I.Ciprofloxacin causes cytoskeletal changes and detachment of human and rat chondrocytes in vitro.
Arch Toxicol. 2000 Jan;73(10-11):557-63.
PMID: 10663387 [PubMed - indexed for MEDLINE]

48    Reeta K, Uppal R, Jhaj R, Malhotra S, Bhargava VK.Adverse drug reactions to fluoroquinolones in pediatric patients in a tertiary care hospital.
Indian J Physiol Pharmacol. 2000 Jan;44(1):113-4. No abstract available.
PMID: 10919107 [PubMed - indexed for MEDLINE]

49    van der Linden PD, van de Lei J, Nab HW, Knol A, Stricker BH.Achilles tendinitis associated with fluoroquinolones.
Br J Clin Pharmacol. 1999 Sep;48(3):433-7.
PMID: 10510157 [PubMed - indexed for MEDLINE]

50    Bender WJ.The use of quinolones in pediatric patients.
S D J Med. 1999 Sep;52(9):351-2. No abstract available.
PMID: 10522470 [PubMed - indexed for MEDLINE]

51    Lewis JR, Gums JG, Dickensheets DL.Levofloxacin-induced bilateral Achilles tendonitis.
Ann Pharmacother. 1999 Jul-Aug;33(7-8):792-5.
PMID: 10466906 [PubMed - indexed for MEDLINE]

52    Takizawa T, Hashimoto K, Minami T, Yamashita S, Owen K.The comparative arthropathy of fluoroquinolones in dogs.
Hum Exp Toxicol. 1999 Jun;18(6):392-9.
PMID: 10413244 [PubMed - indexed for MEDLINE]

53    Harrell RM.Fluoroquinolone-induced tendinopathy: what do we know?
South Med J. 1999 Jun;92(6):622-5. Review.
PMID: 10372859 [PubMed - indexed for MEDLINE]

54    Beluche LA, Bertone AL, Anderson DE, Kohn CW, Weisbrode SE.In vitro dose-dependent effects of enrofloxacin on equine articular cartilage.
Am J Vet Res. 1999 May;60(5):577-82.
PMID: 10328427 [PubMed - indexed for MEDLINE]

55    Schaad UB.Pediatric use of quinolones.
Pediatr Infect Dis J. 1999 May;18(5):469-70. No abstract available.
PMID: 10353524 [PubMed - indexed for MEDLINE]

56    Jafri HS, McCracken GH Jr.Fluoroquinolones in paediatrics.
Drugs. 1999;58 Suppl 2:43-8. Review.
PMID: 10553704 [PubMed - indexed for MEDLINE]

57    Gabutti L, Stoller R, Marti HP.[Fluoroquinolones as etiology of tendinopathy]
Ther Umsch. 1998 Sep;55(9):558-61. German.
PMID: 9789471 [PubMed - indexed for MEDLINE]

58    Forster C, Rucker M, Shakibaei M, Baumann-Wilschke I, Vormann J, Stahlmann R.Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures.
Arch Toxicol. 1998 Jun;72(7):411-9.
PMID: 9708880 [PubMed - indexed for MEDLINE]

60    Marti HP, Stoller R, Frey FJ.Fluoroquinolones as a cause of tendon disorders in patients with renal failure/renal transplants.
Br J Rheumatol. 1998 Mar;37(3):343-4. Review. No abstract available.
PMID: 9566681 [PubMed - indexed for MEDLINE]

61    Bertin P, Gillet P, Treves R, Netter P.[Do some drugs have adverse effects on cartilage?]
Therapie. 1998 Jan-Feb;53(1):17-20. Review. French.
PMID: 9773095 [PubMed - indexed for MEDLINE]

62    Menschik M, Neumuller J, Steiner CW, Erlacher L, Koller M, Ullrich R, Graninger W, Graninger WB.Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro.
Antimicrob Agents Chemother. 1997 Nov;41(11):2562-5.
PMID: 9371369 [PubMed - indexed for MEDLINE]

63    Burkhardt JE, Walterspiel JN, Schaad UB.Quinolone arthropathy in animals versus children.
Clin Infect Dis. 1997 Nov;25(5):1196-204. Review.
PMID: 9402381 [PubMed - indexed for MEDLINE]

64    Decoq G, Moriniere P, Dufour I, Chetaille E, Andrejak M.[Is hemodialysis a risk factor for tendinopathies due to fluoroquinolones?]
Therapie. 1997 Nov-Dec;52(6):613-4. French. No abstract available.
PMID: 9734119 [PubMed - indexed for MEDLINE]

65    Kashida Y, Kato M.Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats.
Toxicol Pathol. 1997 Nov-Dec;25(6):635-43.
PMID: 9437810 [PubMed - indexed for MEDLINE]

66    Vormann J, Forster C, Zippel U, Lozo E, Gunther T, Merker H, Stahlmann R.Effects of magnesium deficiency on magnesium and calcium content in bone and cartilage in developing rats in correlation to chondrotoxicity.
Calcif Tissue Int. 1997 Sep;61(3):230-8.
PMID: 9262515 [PubMed - indexed for MEDLINE]

67    Sabella C, Goldfarb J.Fluoroquinolone therapy in pediatrics: where we stand.
Clin Pediatr (Phila). 1997 Aug;36(8):445-8. Review. No abstract available.
PMID: 9272317 [PubMed - indexed for MEDLINE]

68    Kahn MF, Hayem G.Tendons and fluoroquinolones. Unresolved issues.
Rev Rhum Engl Ed. 1997 Jul-Sep;64(7-9):437-9. Review. No abstract available.
PMID: 9338923 [PubMed - indexed for MEDLINE]

69    Koeger AC, Bellaiche L, Roger B.Magnetic resonance imaging in fluoroquinolone induced tendinopathy.
J Rheumatol. 1997 May;24(5):1015-7. No abstract available. Erratum in: J Rheumatol 1998 Jan;25(1):193.
PMID: 9150105 [PubMed - indexed for MEDLINE]

70    Schou HS.[Fluorquinones and tendinitis]
Ugeskr Laeger. 1997 Feb 3;159(6):784-5. Danish. No abstract available.
PMID: 9045475 [PubMed - indexed for MEDLINE]

71    Levadoux M, Carli P, Gadea JF, De Mauleon De Bruyere P, Perre C.[Repeated rupture of the extensor tendons of the hand due to fluoroquinolones. Apropos of a case]
Ann Chir Main Memb Super. 1997;16(2):130-3. French.
PMID: 9289004 [PubMed - indexed for MEDLINE]

72    de la Garza Estrada VA, Vazquez Caballero R, Camacho Carranza JL.Achilles tendon rupture and fluoroquinolones use: report of two cases.
Arch Med Res. 1997 Autumn;28(3):429-30.
PMID: 9291644 [PubMed - indexed for MEDLINE]

73    Hampel B, Hullmann R, Schmidt H.Ciprofloxacin in pediatrics: worldwide clinical experience based on compassionate use--safety report.
Pediatr Infect Dis J. 1997 Jan;16(1):127-9; discussion 160-2. Review.
PMID: 9002122 [PubMed - indexed for MEDLINE]

74    Warren RW.Rheumatologic aspects of pediatric cystic fibrosis patients treated with fluoroquinolones.
Pediatr Infect Dis J. 1997 Jan;16(1):118-22; discussion 123-6. Review.
PMID: 9002121 [PubMed - indexed for MEDLINE]

75    Hampel B, Hullmann R, Schmidt H.Ciprofloxacin in pediatrics: worldwide clinical experience based on compassionate use--safety report.
Pediatr Infect Dis J. 1997 Jan;16(1):127-9; discussion 160-2. Review.
PMID: 9002122 [PubMed - indexed for MEDLINE]

76    Nightingale SL.From the Food and Drug Administration.
JAMA. 1996 Sep 11;276(10):774. No abstract available.
PMID: 8769577 [PubMed - indexed for MEDLINE]

77    McGarvey WC, Singh D, Trevino SG.Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review.
Foot Ankle Int. 1996 Aug;17(8):496-8. Review.
PMID: 8863030 [PubMed - indexed for MEDLINE]

78    Pierfitte C, Royer RJ.Tendon disorders with fluoroquinolones.
Therapie. 1996 Jul-Aug;51(4):419-20. No abstract available.
PMID: 8953821 [PubMed - indexed for MEDLINE]

79    Loeuille D, Gillet P, Netter P.Fluoroquinolone induced arthralgia and magnetic resonance imaging.
J Rheumatol. 1996 Jul;23(7):1313-4. No abstract available.
PMID: 8823722 [PubMed - indexed for MEDLINE]

80    Zabraniecki L, Negrier I, Vergne P, Arnaud M, Bonnet C, Bertin P, Treves R.Fluoroquinolone induced tendinopathy: report of 6 cases.
J Rheumatol. 1996 Mar;23(3):516-20.
PMID: 8832995 [PubMed - indexed for MEDLINE]

81    Schaad UB.[Use of quinolones in children and articular risk]
Arch Pediatr. 1996 Feb;3(2):183-4. French. No abstract available.
PMID: 8785543 [PubMed - indexed for MEDLINE]

82    Gendrel D.[Use of fluoroquinolones in children]
Arch Pediatr. 1996;3 Suppl 1:292s-294s. French. No abstract available.
PMID: 8796046 [PubMed - indexed for MEDLINE]

83    Forster C, Kociok K, Shakibaei M, Merker HJ, Stahlmann R.Quinolone-induced cartilage lesions are not reversible in rats.
Arch Toxicol. 1996;70(8):474-81.
PMID: 8783810 [PubMed - indexed for MEDLINE]

84    Linseman DA, Hampton LA, Branstetter DG.Quinolone-induced arthropathy in the neonatal mouse. Morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin.
Fundam Appl Toxicol. 1995 Nov;28(1):59-64.
PMID: 8566484 [PubMed - indexed for MEDLINE]

85    Scheen AJ.[Secondary effects of fluoroquinolones: experience of French drug monitoring]
Rev Med Liege. 1995 Nov;50(11):492-3. French. No abstract available.
PMID: 8532999 [PubMed - indexed for MEDLINE]

86    Stahlmann R, Forster C, Shakibaei M, Vormann J, Gunther T, Merker HJ.Magnesium deficiency induces joint cartilage lesions in juvenile rats which are identical to quinolone-induced arthropathy.
Antimicrob Agents Chemother. 1995 Sep;39(9):2013-8.
PMID: 8540708 [PubMed - indexed for MEDLINE

87    Arico M, Bossi G, Caselli D, Cosi G, Villa A, Beluffi G, Genovese E.Long-term magnetic resonance survey of cartilage damage in leukemic children treated with fluoroquinolones.
Pediatr Infect Dis J. 1995 Aug;14(8):713-4. No abstract available.
PMID: 8532433 [PubMed - indexed for MEDLINE]

88    Carvalho WA.[Pharmacology, clinical indications and toxicity of modern fluoroquinolones]
Rev Assoc Med Bras. 1995 Jul-Aug;41(4):293-304. Review. Portuguese. No abstract available.
PMID: 8731611 [PubMed - indexed for MEDLINE]

89    Kato M, Takada S, Kashida Y, Nomura M.Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats.
Toxicol Pathol. 1995 May-Jun;23(3):385-92.
PMID: 7659960 [PubMed - indexed for MEDLINE]

90    Gendrel D, Aujard Y.[Quinolones in pediatrics]
Arch Pediatr. 1995 May;2(5):409-11. Review. French. No abstract available.
PMID: 7640729 [PubMed - indexed for MEDLINE]

91    Szarfman A, Chen M, Blum MD.More on fluoroquinolone antibiotics and tendon rupture.
N Engl J Med. 1995 Jan 19;332(3):193. No abstract available.
PMID: 7800023 [PubMed - indexed for MEDLINE]

92    Pierfitte C, Gillet P, Royer RJ.More on fluoroquinolone antibiotics and tendon rupture.
N Engl J Med. 1995 Jan 19;332(3):193. No abstract available.
PMID: 7800022 [PubMed - indexed for MEDLINE

93    Pierfitte C.[Tendinopathies and fluoroquinolones: a public health problem? Value of drug monitoring studies]
Bull Soc Sci Med Grand Duche Luxemb. 1995;132(3):39-40. French. No abstract available.
PMID: 8665625 [PubMed - indexed for MEDLINE]

94    Hanton G, Le Net JL, Ruty B, Leblanc B.Characterization of the arteritis induced by infusion of rats with UK-61,260, an inodilator, for 24 h. A comparison with the arteritis induced by fenoldopam mesylate.
Arch Toxicol. 1995;69(10):698-704.
PMID: 8572928 [PubMed - indexed for MEDLINE]

105    Chevalier X, Albengres E, Voisin MC, Tillement JP, Larget-Piet B.A case of destructive polyarthropathy in a 17-year-old youth following pefloxacin treatment.
Drug Saf. 1992 Jul-Aug;7(4):310-4.
PMID: 1524702 [PubMed - indexed for MEDLINE]

106    Chaslerie A, Bannwarth B, Landreau JM, Yver L, Begaud B.[Tendon rupture and fluoro-quinolones: an undesirable effect of drug selection]
Rev Rhum Mal Osteoartic. 1992 Apr;59(4):297-8. French. No abstract available.
PMID: 1496284 [PubMed - indexed for MEDLINE]

111    Burkhardt JE, Hill MA, Carlton WW, Kesterson JW.Histologic and histochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone.
Vet Pathol. 1990 May;27(3):162-70.
PMID: 2353417 [PubMed - indexed for MEDLINE]

112    Kesseler A, Lacassie A, Hugot JP, Talon P, Thomas D, Astier L.[Arthropathies following the administration of pefloxacin to an adolescent with mucoviscidosis]
Ann Pediatr (Paris). 1989 Apr;36(4):275-8. French.
PMID: 2742312 [PubMed - indexed for MEDLINE]

113    Chalumeau M, Gendrel D, Breart G, Pons G.[An example of hospital-based pharmacoepidemiology in paediatrics: tolerance of fluoroquinolones]
Arch Pediatr. 2004 Jun;11(6):500-2. French. No abstract available.
PMID: 15158810 [PubMed - in process]

114    Perry AC, Prpa B, Rouse MS, Piper KE, Hanssen AD, Steckelberg JM, Patel R.Levofloxacin and trovafloxacin inhibition of experimental fracture-healing.
Clin Orthop. 2003 Sep;(414):95-100.
PMID: 12966282 [PubMed - indexed for MEDLINE]

115    Kappel EM, Shakibaei M, Bello A, Stahlmann R.Effects of the Des-F(6)-quinolone garenoxacin (BMS-284756), in comparison to those of ciprofloxacin and ofloxacin, on joint cartilage in immature rats.
Antimicrob Agents Chemother. 2002 Oct;46(10):3320-2.
PMID: 12234871 [PubMed - indexed for MEDLINE]

118    Vergne P, Bertin P, Bonnet C, Scotto C, Treves R.Drug-induced rheumatic disorders: incidence, prevention and management.
Drug Saf. 2000 Oct;23(4):279-93. Review.
PMID: 11051216 [PubMed - indexed for MEDLINE]

126     Dagan R.Fluoroquinolones in paediatrics--1995.
Drugs. 1995;49 Suppl 2:92-9. Review.
PMID: 8549423 [PubMed - indexed for MEDLINE]