LEVOFLOXACIN Reports of adverse reactions Belgium. Levofloxacin (Tavanic) has been associated with a number of adverse reactions, including 12 cases of tendinitis, which have been reported to the Belgian centre for pharmaco-vigilance since the drug's launch in August 2000. Of the 12 reports of levofloxacin-associated tendinitis, 6 cases involved tendon rupture. Also, in 5 cases, concomitant corticosteroid therapy may have been a contributing risk factor. The mean age of the patients was 74 years, and it appears that the risk of tendinitis with levofloxacin therapy increases with age. The centre has also received 8 reports of allergic reactions with levofloxacin, including 7 of angioneurotic oedema and 1 of anaphylaxis.