HYPO / HYPERGLYCEMIA

Dysglycemia and fluoroquinolones: Are you putting patients at risk

Hypoglycemic Effect of Ciprofloxacin in Elderly Patients Not a Class Effect: Presented at IDSA

Fatal hypoglycemia induced by levofloxacin

Health Canada warned yesterday that an Gatifloxacin, sold under the brand name Tequin, has been associated with cases of both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) that can be serious and life-threatening.
The Canadian Press TORONTO (Dec 21, 2005)

A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone. Mohr JF, McKinnon PS, Peymann PJ, Kenton I, Septimus E, Okhuysen PC. Division of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. john.mohr@uth.tmc.edu

A retrospective, comparative evaluation of dysglycemias in hospitalized patients receiving gatifloxacin, levofloxacin, ciprofloxacin, or ceftriaxone. Mohr JF, McKinnon PS, Peymann PJ, Kenton I, Septimus E, Okhuysen PC.

Gatifloxacin-induced hepatotoxicity and acute pancreatitis.
Cheung O, Chopra K, Yu T, Nalesnik MA, Amin S, Shakil AO.

Association of Tequin(Gatifloxacin) With Serious Hypoglycemia And Hyperglycemia
OTTAWA, CANADA -- December 21, 2005 -- Bristol-Myers Squibb

Link Between Tequin (gatifloxacin) and Hypoglycemia Strengthened

Fatal hypoglycemia associated with levofloxacin.

The results of this review indicate that the CADRMP reports for hypoglycemia or hyperglycemia with gatifloxacin compared with either levofloxacin or moxifloxacin may have identified a safety signal for gatifloxacin. A systematic analysis to determine causality, risk factors, and incidence of hypoglycemia or hyperglycemia may be warranted. 

Glucose Homeostasis Abnormalities and Fluoroquinolones: A Canadian Thought-Leader Perspective From Stephen D. Shafran, MD, FRCPC

Hypoglycemia and hyperglycemia induced by a fluoroquinolone

Canadian Adverse Reaction Newsletter Volume 13, Number 3, July 2003: Gatifloxacin (Tequin™): hypoglycemia and hyperglycemia

Gatifloxacin-Induced Hyperglycemia.

Possible Gatifloxacin-Induced Hyperglycemia Amy R Donaldson, PharmD

Possible gatifloxacin-induced hypoglycemia.  Baker SE, Hangii MC.

Possible Gatifloxacin-Induced Hyperglycemia -- Donaldson et al
(Foreign report)

Possible gatifloxacin-induced hyperglycemia. Donaldson AR, Vandiver JR, Finch CK.

Glucose Homeostasis Abnormalities and Fluoroquinolones: A Canadian Thought-Leader Perspective From Stephen D. Shafran, MD, FRCPC

Hypoglycemia and Hyperglycemia Associated with Gatifloxacin Use in Elderly Patients

Severe hyperglycemia during gatifloxacin therapy in patients without diabetes.

The following citations have no abstract, full text can be purchased from the various sites noted or writing the authors directly:


Hypoglycemia, hyperglycemia, and gatifloxacin.
Khovidhunkit W, Sunthornyothin S.
Ann Intern Med. 2004 Dec 21;141(12):969. No abstract available.
PMID: 15611501 [PubMed - indexed for MEDLINE]
http://www.annals.org/cgi/content/full/141/12/969

Gatifloxacin-induced hyperglycemia.
Happe MR, Mulhall BP, Maydonovitch CL, Holtzmuller KC. 
Ann Intern Med. 2004 Dec 21;141(12):968-9. No abstract available.
PMID: 15611500 [PubMed - indexed for MEDLINE]
http://www.annals.org/cgi/content/full/141/12/968

Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients. Biggs WS.
J Am Board Fam Pract. 2003 Sep-Oct;16(5):455-7.
Midland Family Practice Residency Program, MidMichigan Medical Center, Midland, MI 48640, USA. wendy.biggs@midmichigan.org
http://www.jabfp.org/cgi/content/full/16/5/455

Endocr Pract. 2004 Jan-Feb;10(1):86.
Gatifloxacin-induced hyperglycemia.
Bhatia V, Bhatia R, Dhindsa S.
PMID: 15251629 [PubMed - indexed for MEDLINE]

Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents.
Am J Med. 2002 Aug 15;113(3):232-4.
Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH.
Divisions of Cardiology and Infectious Disease, Winthrop-University Hospital, Mineola, New York 11501, USA.
http://linkinghub.elsevier.com/retrieve/pii/S0002934302011580

 

From Pubmed/Medline

Hypoglycemia (8)

1    Biggs WS.Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients.
 J Am Board Fam Pract. 2003 Sep-Oct;16(5):455-7. No abstract available.
PMID: 14645336 [PubMed - indexed for MEDLINE]

2    [No authors listed]Hypoglycemia and hyperglycemia with fluroroquinolones.
 Med Lett Drugs Ther. 2003 Aug 4;45(1162):64. No abstract available.
PMID: 12888740 [PubMed - indexed for MEDLINE]

3    Baker SE, Hangii MC.Possible gatifloxacin-induced hypoglycemia.
 Ann Pharmacother. 2002 Nov;36(11):1722-6.
PMID: 12398567 [PubMed - indexed for MEDLINE]

4    Menzies DJ, Dorsainvil PA, Cunha BA, Johnson DH.Severe and persistent hypoglycemia due to gatifloxacin interaction with oral hypoglycemic agents.
 Am J Med. 2002 Aug 15;113(3):232-4. No abstract available.
PMID: 12208383 [PubMed - indexed for MEDLINE]

5    Donaldson AR, Vandiver JR, Finch CK.Possible gatifloxacin-induced hyperglycemia.
 Ann Pharmacother. 2004 Apr;38(4):602-5. Epub 2004 Feb 24.
PMID: 14982977 [PubMed - indexed for MEDLINE]

6    Cheung O, Chopra K, Yu T, Nalesnik MA, Amin S, Shakil AO.Gatifloxacin-induced hepatotoxicity and acute pancreatitis.
 Ann Intern Med. 2004 Jan 6;140(1):73-4. No abstract available.
PMID: 14706991 [PubMed - indexed for MEDLINE]

7    Bhatia V, Bhatia R, Dhindsa S.Gatifloxacin-induced hyperglycemia.
 Endocr Pract. 2004 Jan-Feb;10(1):86. No abstract available.
PMID: 15251629 [PubMed - indexed for MEDLINE]

8    Arce FC, Bhasin RS, Pasmantier R.Severe hyperglycemia during gatifloxacin therapy in patients without diabetes.
 Endocr Pract. 2004 Jan-Feb;10(1):40-4.
PMID: 15251620 [PubMed - indexed for MEDLINE]