The Fluoroquinolone Toxicity Research Foundation

 

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Popular Research Articles:

Tendinitis Associated With Levofloxacin

Levofloxacin (Tavanic) has been associated with a number of adverse reactions, including 12 cases of tendinitis

Evidence of tendinitis provoked by fluoroquinolone treatment : a case-control study.

Rupture of adductor longus tendon due to ciprofloxacin.

Achilles tendinitis associated to levofloxacin: report of 4 cases

Quinolone antibiotics have been associated with tendon problems since they were introduced in the 1980s

A Long-Term Study of the Incidence of Musculoskeletal Disorders in Children Who Have Received Levofloxacin or a Standard Non-Fluoroquinone Therapy for Acute Bacterial Infection This study is no longer recruiting patients. Sponsored by: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Ultrastructural changes of the gemifloxacin on Achilles tendon in immature rats: comparison with those of ciproxacin and ofloxacin. Bae CS, Oh DM, Bae JG, Kim JC, Kim SH, Kim SG, Jeong MJ, Kim YS, Lim SC.

Fluoroquinolone-induced arthralgia and myalgia in the treatment of sinusitis. O-Lee T, Stewart CE 4th, Seery L, Church CA.

QUINOLONE INDUCED MYOTENDINOPATHY
Vasuki Narayanasamy M.D, Harsha Vyas M.D, Guha Krishnaswamy M.D.


Stingray bite and bilateral Achilles tendonitis due to LEVOFLOXACIN use  Lini S. Bhatia, M.D., PGY2, Department of Internal Medicine, James H. Quillen College of Medicine, ETSU, Johnson City, TN

Age-dependent effects on redox status, oxidative stress, mitochondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells.

A cautionary tale of tendonitis [1999] Peter Jones is a rheumatologist at Queen Elizabeth Hospital, Rotorua http://www.rnzcgp.org.nz/NZFP/Issues/June99/focuspj.htm:

Avoiding Achilles tendon ruptures in the elderly - Literature Monitor Clinician Reviews, Oct, 2003
It has now been confirmed that quinolones, the most frequently prescribed antibacterial agents, increase the risk of Achilles tendon rupture in elderly patients, according to van der Linden et al

Antimicrobial therapy with fluoroquinolones can be associated with tendinitis and other tendon disorders as an adverse reaction associated with this class of antimicrobials.

 Fluoroquinolone antibiotics may cause tendon pain and rupture.

Fluoroquinolone-induced arthralgia and myalgia in the treatment of sinusitis.
 

Inhibitory effects of the quinolone antibiotics trovafloxacin, ciprofloxacin, and levofloxacin on osteoblastic cells in vitro.
Holtom PD, Pavkovic SA, Bravos PD, Patzakis MJ, Shepherd LE, Frenkel B.
Department of Orthopaedic Surgery and Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA

Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells.
Sendzik J, Shakibaei M, Schafer-Korting M, Stahlmann R.

Four cases of spontaneous tendon rupture associated with Levofloxacin.  The four patients described were originally enrolled into a study of levofloxacin treatment of lower respiratory tract infection. This study included 489 patients treated with levofloxacin, a total of 3217 treatment days. Tendinopathy was not measured as an outcome in the study.

Levofloxacin-induced bilateral Achilles tendonitis Lewis JR, JG Gums, and DL Dickensheets 1999

Foot Ankle Int. 1996 Aug;17(8):496-8. 
Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review.

Rupture of the patellar ligament one month after treatment with fluoroquinolone
Rev Chir Orthop Reparatrice Appar Mot. 2000 Sep;86(5):495-7.

Fluoroquinolone-Associated Tendinopathy: A Critical Review of the Literature
Yasmin Khaliq1 and George G. Zhanel2

J Am Podiatr Med Assoc. 2003 Jul-Aug;93(4):333-5.
Fluoroquinolone therapy and Achilles tendon rupture.
Vanek D, Saxena A, Boggs JM.

Clin Rheumatol. 2003 Dec;22(6):500-1. Epub 2003 Oct 18.
Ciprofloxacin and Achilles' tendon rupture: a causal relationship.

Bilateral simultaneous spontaneous rupture of the Achilles tendon.
Mehra A, Maheshwari R, Case R, Croucher C.

Aten Primaria. 2003 Sep 15;32(4):256
Bilateral Achilles tendinitis as adverse reaction to levofloxacine.

Pharm World Sci. 2001 Jun;23(3):89-92.
Fluoroquinolone use and the change in incidence of tendon ruptures in the Netherlands.
van der Linden PD, Nab HW, Simonian S, Stricker BH, Leufkens HG, Herings RM.

Therapie. 2004 Nov-Dec;59(6):653-5.
Ofloxacin-induced achilles tendinitis in the absence of a predisposition

Rev Rhum Engl Ed. 1999 Jul-Sep;66(7-9):419-21.
Suspected role of ofloxacin in a case of arthalgia, myalgia, and multiple tendinopathy.

Therapie. 2003 Sep-Oct;58(5):463-5.
The myo-tendinopathy caused by levofloxacin

Reumatismo. 2003 Oct-Dec;55(4):267-9.
Levofloxacin-induced bilateral rupture of the Achilles tendon: clinical and sonographic findings

An Med Interna. 2004 Mar;21(3):154.
Achilles bilateral tendonitis and levofloxacin

J Orthop Sci. 2004;9(2):186-90.
Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.

Scand J Infect Dis. 2004;36(4):315-6.
Recurrent tendinitis after treatment with two different fluoroquinolones.

Rupture of multiple tendons after levofloxacin therapy.
Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, Trechot P.

Arch Orthop Trauma Surg. 2005 Mar;125(2):124-6. Epub 2005 Jan 12.
Missed Achilles tendon rupture due to oral levofloxacin: surgical treatment and result.

Infection. 2000 Jul-Aug;28(4):256-7.
Fluoroquinolone-induced tendinopathy: also occurring with levofloxacin.

Aten Primaria. 2004 Mar 15;33(4):214.
Muscle and tendon problems as a side-effect of levofloxacine: review of a case

Ann Pharmacother. 1999 Jul-Aug;33(7-8):792-5.
Levofloxacin-induced bilateral Achilles tendonitis.

Rev Clin Esp. 2001 Sep;201(9):539-40.
Achilles pain and functional impotence in a patient with chronic obstructive pulmonary disease with pneumonia. Tendon rupture caused by levofloxacin

Gastroenterol Hepatol. 2003 Jan;26(1):53-4.
Rupture of the Achilles' tendon secondary to levofloxacin

An Med Interna. 2005 Jan;22(1):28-30.
Partial bilateral rupture of the Achilles tendon associated to levofloxacin

Med Clin (Barc). 2003 Jan 25;120(2):78-9.
Comment on: Med Clin (Barc). 2002 Jun 8;119(1):38-9.
Levofloxacin and bilateral spontaneous Achilles tendon rupture

Rev Med Chil. 2002 Nov;130(11):1277-81.
Achilles tendinitis associated to levofloxacin: report of 4 cases

J Antimicrob Chemother. 2003 Mar;51(3):747-8.
Spontaneous Achilles tendon rupture in patients treated with levofloxacin.

Foot Ankle Int. 2003 Feb;24(2):122-4.
Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to levofloxacin.

Chemotherapy. 2003 May;49(1-2):90-1.
Reoccurrence of levofloxacin-induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?

Ann Pharmacother. 2003 Jul-Aug;37(7-8):1014-7.
Levofloxacin-associated Achilles tendon rupture.

Pharmacol Exp Ther. 2004 Jan;308(1):394-402. Epub 2003 Oct 20. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress.

Clin Rheumatol. 2003 Oct;22(4-5):367-8.
Bilateral Achilles tendinitis with spontaneous rupture induced by levofloxacin in a patient with systemic sclerosis.

Scand J Infect Dis. 2003;35(10):768-70.
Levofloxacin-associated Achilles tendon rupture and tendinopathy.

J Am Board Fam Pract. 2003 Sep-Oct;16(5):458-60.
Levofloxacin-induced tendon rupture: a case report and review of the literature.

Expert Opin Drug Saf. 2005 Mar;4(2):299-309.
Fluoroquinolones and tendon disorders.
Melhus A.

Worldwide Post Marketing Surveillance

Animal and Human Studies

Taking FLUOROQUINOLONES and CORTICOSTEROIDS may cause problems with your tendons

One of the most common and pronounced adverse drug reactions to fluoroquinolones is often manifested as severe joint, muscle and tendon pain.

Physical Therapist Management of Fluoroquinolone-Induced Achilles Tendinopathy

Fluoroquinolones and risk of Achilles tendon disorders: case-control study BMJ 2002;324:1306-1307 ( 1 June )

Physical Therapist Management of Fluoroquinolone-Induced Achilles Tendinopathy

The Expert Opinion Complete Ruptures of the Achilles Tendon

4 cases of levaquin induced tendintis (orign spanish)

Study Confirms Increased Risk of Achilles Tendon Rupture With Fluoroquinolone Use

Descriptions of {fluoroquinolone induced} tendon damage

Long term outcome after Fluoroquinolones tendinopathies
13/01/2004

Tendonitis associated with fluoroquinolones may be prolonged.

Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.   J Orthop Sci 2004;9(2):186-90 (ISSN: 0949-2658)  Kowatari K; Nakashima K; Ono A; Yoshihara M; Amano M; Toh S  Department of Orthopaedic Surgery, Aomori Rosai Hospital, 1 Minamigaoka, Shirogane-machi, Hachinohe 031-8551, Japan.

Levofloxacin-associated Achilles tendon rupture and tendinopathy.  Scand J Infect Dis 2003;35(10):768-70 (ISSN: 0036-5548)   Melhus A; Apelqvist J; Larsson J; Eneroth M   Department of Medical Microbiology, Malmo University Hospital, Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se.

Levofloxacin and trovafloxacin inhibition of experimental fracture-healing.   Clin Orthop 2003 Sep;(414):95-100 (ISSN: 0009-921X)   Perry AC; Prpa B; Rouse MS; Piper KE; Hanssen AD; Steckelberg JM; Patel R   Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Levofloxacin-associated Achilles tendon rupture. Ann Pharmacother 2003 Jul-Aug;37(7-8):1014-7 (ISSN: 1060-0280) Mathis AS; Chan V; Gryszkiewicz M; Adamson RT; Friedman GS  Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA. smathis@sbhcs.com.

Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to levofloxacin.  Foot Ankle Int 2003 Feb;24(2):122-4 (ISSN: 1071-1007) Cebrian P; Manjon P; Caba P  Departamento de Radiodiagnostico, Hospital Universitario 12 de Octubre, Madrid, Spain. pcvbb@yahoo.es.

Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis
Tina Papastavros, Lisa R. Dolovich, Anne Holbrook, Lori Whitehead, and Mark Loeb

Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells.
Sendzik J, Shakibaei M, Schafer-Korting M, Stahlmann R.

Expert Opin Drug Saf. 2005 Mar;4(2):299-309.
Fluoroquinolones and tendon disorders.
Melhus A.
Lund University, Department of Medical Microbiology, Malmo University Hospital, S-205 02 Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se

Aten Primaria. 2005 Sep 30;36(5):286-7. [Tendinitis associated with levofloxacin] [Article in Spanish] Alvarez Luque I, Gomariz Santacecilia M, Villamor Baliarda E, Rando Matos Y, Garcia Fernandez Y.

Chondrotoxicity of quinolones in vivo and in vitro.  Hildebrand H, Kempka G, Schluter G, Schmidt M.  Bayer AG, Fachbereich Toxikologie, Pharma-Forschungszentrum, Wuppertal, Germany

Expert Opin Drug Saf. 2005 Mar;4(2):299-309. Fluoroquinolones and tendon disorders. Melhus A. Lund University, Department of Medical Microbiology, Malmo University Hospital, S-205 02 Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se

Rupture of multiple tendons after levofloxacin therapy. Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, Trechot P. Pneumology Department, Maillot Hospital, 54150 Briey, France.

Irish Medicines Board Drug Safety Newsletter - Drug Safety – January 2002 - Issue No.14 The Pharmacovigilance Unit, Irish Medicines Board,Earlsford Centre, Earlsford Terrace, Dublin2.
Tel: 676 4971-7 Fax: 676 7836

TI - Epicondylitis after treatment with fluoroquinolone antibiotics.

Spontaneous Tendon Ruptures and Severe Tendinitis associated with fluoroquinolones

A case of rhabdomyolysis with fatal outcome after a treatment with levofloxacin.

Tendon Rupture associated with fluoroquinolones / Animals Studies

Casperian et al

Fluoroquinolones are relatively safe, effective antibiotics. As their use becomes more frequent, so will the adverse side effects.

Persistent and chronic poly arthritis

The pharmacological management of drug-induced rheumatic disorders.

Conventional Arthritis treatments generally compromise by relieving physical symptoms only, which are secondary to a primary cause.

Regional Pain Syndromes: Diagnosis and Management

Ciprofloxacin-associated Achilles tendon rupture in a hemodialysis patient

Tendonitis is an inflammatory condition characterized by pain at tendinous insertions into bone.

Fluoroquinolones – tendinitis : update

Tendinitis and tendon rupture with fluoroquinolones

The Achilless heel of fluoroquinolones

The comparative arthropathy of fluoroquinolones in dogs

Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro

Fluoroquinolone's Effect on Growth of Human Chondrocytes and Chondrosarcomas: In Vitro and In Vivo Correlation

Repeated rupture of the extensor tendons of the hand due to fluoroquinolones. Apropos of a case

Ultrastructure of Achilles Tendons of Rats Treated with Ofloxacin and Fed a Normal or Magnesium-Deficient Diet

Antibacterial quinolones induce joint cartilage lesions in juvenile animals at relatively low doses. They are therefore contraindicated in children and adolescents as well as in pregnant and lactating women.

Since 1983, fluoroquinolones have been reported to be associated with tendon pathology

Fluoroquinolone-Induced Tendinopathy: What Do We Know?

Their potential role in routine use for paediatric patients will remain limited because of potential joint complications

Fluorine level in the bone and cartilage in children treated with ciprofloxacin

The effect of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism.

Fluoroquinolones in Pediatrics

Petition to Require a Warning on All Fluoroquinolone Antibiotics

Fluoroquinolones and Risk of Achilles Tendon Disorders

Spontaneous rupture of Achilles tendon and fluoroquinolones

Ciprofloxacin Inhibition of Experimental Fracture-Healing

Quinolone-associated tendonitis: a potential problem in COPD?

The Pathology & Healing of Tendinosis

One of the most common and pronounced adverse drug reactions to fluoroquinolones is often manifested as severe joint, muscle and tendon pain

Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.

Long term outcome after Fluoroquinolones tendinopathies
13/01/2004

In vitro discrimination of fluoroquinolones toxicity on tendon cells: Involvement of Oxidative Stress.

Reappraisal of quinolone tolerability. The experience of their musculoskeletal adverse effects.

Quinolone-Related Achilles Tendon Rupture Risk High in Elderly on Corticosteroids

Arthritis and other chronic joint problems are far more widespread than estimated just five years ago, affecting one in three U.S. adults, or 69.9 million people in all

Tendonitis associated with fluoroquinolones may be prolonged.

Medications-Impair-Shoulder-Healing

Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.

Levofloxacin-associated Achilles tendon rupture and tendinopathy.

Levofloxacin and trovafloxacin inhibition of experimental fracture-healing.

Levofloxacin-associated Achilles tendon rupture.

Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to levofloxacin.

Fluoroquinolones and tendon ruptures / reported last week at the 41st annual meeting of the Infectious Diseases Society of America.
Study Confirms Increased Risk of Achilles Tendon Rupture With Fluoroquinolone Use  Peggy Peck  Oct. 15, 2003

Fluoroquinolones and tendon disorders Mersey ADR Newsletter
Issue 22 Autumn 2003

Quinolone toxicity: methods of assessment.

Ciprofloxacin reduces the stimulation of prostaglandin E2 output by interleukin-1ß in human tendon-derived cells

In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress

Expert Opin Drug Saf. 2005 Mar;4(2):299-309.
Fluoroquinolones and tendon disorders.
Melhus A.
Lund University, Department of Medical Microbiology, Malmo University Hospital, S-205 02 Malmo, Sweden. asa.melhus@mikrobiol.mas.lu.se

 

 


Citations with no abstracts

Additional Research is also available in the Tendon_Archives, Arthritis Archives and the Muscle Archives

PDF Files:

Fluoroquinolones associated with Achilles’ tendinitis circa 1983

Tendinopathies as a result of fluoroquinolone therapy have been well known since 1983

From PubMed:

1.    Tomas ME, Perez Carreras M, Morillasa JD, Castellano G, Solis JA.
[Rupture of the Achilles' tendon secondary to levofloxacin]
Gastroenterol Hepatol. 2003 Jan;26(1):53-4. Spanish. No abstract available.
PMID: 12525331 [PubMed - indexed for MEDLINE]
 

2.     Hugo-Persson M.
[Rupture of the Achilles tendon after ciproxine therapy]
Lakartidningen. 1996 Apr 17;93(16):1520. Swedish. No abstract available.
PMID: 8667750 [PubMed - indexed for MEDLINE]


3.
McGarvey WC, Singh D, Trevino SG.
Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a
case report and literature review.
Foot Ankle Int. 1996 Aug;17(8):496-8. Review.
PMID: 8863030 [PubMed - indexed for MEDLINE]

4.
Jagose JT, McGregor DR, Nind GR, Bailey RR.
Achilles tendon rupture due to ciprofloxacin.
N Z Med J. 1996 Dec 13;109(1035):471-2. No abstract available.
PMID: 9006634 [PubMed - indexed for MEDLINE]

5.
West MB, Gow P.
Ciprofloxacin, bilateral Achilles tendonitis and unilateral tendon rupture--a case report.
N Z Med J. 1998 Jan 23;111(1058):18-9. No abstract available.
PMID: 9484431 [PubMed - indexed for MEDLINE]

6.
Kowatari K, Nakashima K, Ono A, Yoshihara M, Amano M, Toh S.
Levofloxacin-induced bilateral Achilles tendon rupture: a case report and review of the literature.
J Orthop Sci. 2004;9(2):186-90. Review.
PMID: 15045551 [PubMed - indexed for MEDLINE]

7.
Chhajed PN, Plit ML, Hopkins PM, Malouf MA, Glanville AR.
Achilles tendon disease in lung transplant recipients: association with ciprofloxacin.
Eur Respir J. 2002 Mar;19(3):469-71.
PMID: 11936524 [PubMed - indexed for MEDLINE]

8.
de La Red G, Mejia JC, Cervera R, Llado A, Mensa J, Font J.
Bilateral Achilles tendinitis with spontaneous rupture induced by levofloxacin in a patient with systemic sclerosis.
Clin Rheumatol. 2003 Oct;22(4-5):367-8. No abstract available.
PMID: 14579169 [PubMed - indexed for MEDLINE]

9.
Mathis AS, Chan V, Gryszkiewicz M, Adamson RT, Friedman GS.
Levofloxacin-associated Achilles tendon rupture.
Ann Pharmacother. 2003 Jul-Aug;37(7-8):1014-7.
PMID: 12841810 [PubMed - indexed for MEDLINE]

10.
Aros C, Flores C, Mezzano S.[Achilles tendinitis associated to levofloxacin: report of 4 cases]
Rev Med Chil. 2002 Nov;130(11):1277-81. Spanish.
PMID: 12587511 [PubMed - indexed for MEDLINE]

11.
Shah P.[Do tendon lesions occur during quinolone administration?]
Dtsch Med Wochenschr. 2003 Oct 17;128(42):2214. German. No abstract available.
PMID: 14562223 [PubMed - indexed for MEDLINE]

12. 
Melhus A, Apelqvist J, Larsson J, Eneroth M.
Levofloxacin-associated Achilles tendon rupture and tendinopathy.
Scand J Infect Dis. 2003;35(10):768-70.
PMID: 14606622 [PubMed - indexed for MEDLINE]

13.
Cebrian P, Manjon P, Caba P.
Ultrasonography of non-traumatic rupture of the Achilles tendon secondary to
levofloxacin.
Foot Ankle Int. 2003 Feb;24(2):122-4.
PMID: 12627618 [PubMed - indexed for MEDLINE]

14. 
Bernacer L, Artigues A, Serrano A.
[Levofloxacin and bilateral spontaneous Achilles tendon rupture]
Med Clin (Barc). 2003 Jan 25;120(2):78-9. Spanish. No abstract available.
PMID: 12570920 [PubMed - indexed for MEDLINE]

15.
Haddow LJ, Chandra Sekhar M, Hajela V, Gopal Rao G.
Spontaneous Achilles tendon rupture in patients treated with levofloxacin.
J Antimicrob Chemother. 2003 Mar;51(3):747-8. No abstract available.
PMID: 12615887 [PubMed - indexed for MEDLINE]


16. Othmani S, Battikh R, Ben Abdallah N.
[The myo-tendinopathy caused by levofloxacin]
Therapie. 2003 Sep-Oct;58(5):463-5. French. No abstract available.
PMID: 14682197 [PubMed - indexed for MEDLINE]

17.
Gutierrez E, Morales E, Garcia Rubiales MA, Valentin MO.
[Levofloxacin and Achilles tendon involvement in hemodialysis patients]
Nefrologia. 2003 Nov-Dec;23(6):558-9. Spanish. No abstract available.
PMID: 15002793 [PubMed - indexed for MEDLINE]

18.
Nuno Mateo FJ, Noval Menendez J, Suarez M, Guinea O.
[Achilles pain and functional impotence in a patient with chronic obstructive pulmonary disease with pneumonia. Tendon rupture caused by levofloxacin]
Rev Clin Esp. 2001 Sep;201(9):539-40. Spanish. No abstract available.
PMID: 11692412 [PubMed - indexed for MEDLINE]

19.
Movin T, Gad A, Guntner P, Foldhazy Z, Rolf C.
Pathology of the Achilles tendon in association with ciprofloxacin treatment.
Foot Ankle Int. 1997 May;18(5):297-9.
PMID: 9167931 [PubMed - indexed for MEDLINE]

20.
Gomez Rodriguez N, Ibanez Ruan J, Gonzalez Perez M.
[Achilles bilateral tendonitis and levofloxacin]
An Med Interna. 2004 Mar;21(3):154. Spanish. No abstract available.
PMID: 15043504 [PubMed - indexed for MEDLINE]

21.
Filippucci E, Farina A, Bartolucci F, Spallacci C, Busilacchi P, Grassi W.[Levofloxacin-induced bilateral rupture of the Achilles tendon: clinical and sonographic findings]
Reumatismo. 2003 Oct-Dec;55(4):267-9. Italian.
PMID: 14872227 [PubMed - indexed for MEDLINE]

22.
Skovgaard D, Feldt-Rasmussen BF, Nimb L, Hede A, Kjaer M.
[Bilateral Achilles tendon rupture in individuals with renal transplantation]
Ugeskr Laeger. 1996 Dec 30;159(1):57-8. Danish.
PMID: 9012076 [PubMed - indexed for MEDLINE]

23.
Burkhardt O, Kohnlein T, Pap T, Welte T.
Recurrent tendinitis after treatment with two different fluoroquinolones.
Scand J Infect Dis. 2004;36(4):315-6.
PMID: 15198194 [PubMed - indexed for MEDLINE]

24.
Mirovsky Y, Pollack L, Arlazoroff A, Halperin N.
[Ciprofloxacin-associated bilateral acute achilles tendinitis]
Harefuah. 1995 Dec 1;129(11):470-2, 535. Hebrew.
PMID: 8846955 [PubMed - indexed for MEDLINE]

25.
Ribard P, Audisio F, Kahn MF, De Bandt M, Jorgensen C, Hayem G, Meyer O, Palazzo E.
Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy.
J Rheumatol. 1992 Sep;19(9):1479-81.
PMID: 1433021 [PubMed - indexed for MEDLINE]

26.
Lewis JR, Gums JG, Dickensheets DL.
Levofloxacin-induced bilateral Achilles tendonitis.
Ann Pharmacother. 1999 Jul-Aug;33(7-8):792-5.
PMID: 10466906 [PubMed - indexed for MEDLINE]

27.
Shinohara YT, Tasker SA, Wallace MR, Couch KE, Olson PE.
What is the risk of Achilles tendon rupture with ciprofloxacin?
J Rheumatol. 1997 Jan;24(1):238-9. No abstract available.
PMID: 9002057 [PubMed - indexed for MEDLINE]

28
Greene BL.Physical therapist management of fluoroquinolone-induced Achilles tendinopathy.
Phys Ther. 2002 Dec;82(12):1224-31.
PMID: 12444881 [PubMed - indexed for MEDLINE]

29
Perrot S, Kaplan G, Ziza JM.
[3 cases of Achilles tendinitis caused by pefloxacin, 2 of them with tendon rupture]
Rev Rhum Mal Osteoartic. 1992 Feb;59(2):162. French. No abstract available.
PMID: 1604233 [PubMed - indexed for MEDLINE]

30
Perrot S, Ziza JM, De Bourran-Cauet G, Desplaces N, Lachand AT.
[A new complication related to quinolones: rupture of Achilles tendon]
Presse Med. 1991 Jul 6-13;20(26):1234. French. No abstract available.
PMID: 1831902 [PubMed - indexed for MEDLINE]

31
Schindler C, Pittrow D, Kirch W.
Reoccurrence of levofloxacin-induced tendinitis by phenoxymethylpenicillin therapy after 6 months: a rare complication of fluoroquinolone therapy?
Chemotherapy. 2003 May;49(1-2):90-1. No abstract available.
PMID: 12756981 [PubMed - indexed for MEDLINE]

32
Fink RJ, Corn RC.
Fracture of an ossified Achilles tendon.
Clin Orthop. 1982 Sep;(169):148-50. No abstract available.
PMID: 6809391 [PubMed - indexed for MEDLINE]

33
Blanco Andres C, Bravo Toledo R.
[Bilateral tendinitis caused by ciprofloxacin]
Aten Primaria. 1998 Feb 28;21(3):184-5. Spanish. No abstract available.
PMID: 9607242 [PubMed - indexed for MEDLINE]

34
Huston KA.
Achilles tendinitis and tendon rupture due to fluoroquinolone antibiotics.
N Engl J Med. 1994 Sep 15;331(11):748. No abstract available.
PMID: 8058092 [PubMed - indexed for MEDLINE]

35
Lee WT, Collins JF.
Ciprofloxacin associated bilateral achilles tendon rupture.
Aust N Z J Med. 1992 Oct;22(5):500. No abstract available.
PMID: 1445042 [PubMed - indexed for MEDLINE]

36
Jones JG.
Achilles tendon rupture following steroid injection.
J Bone Joint Surg Am. 1985 Jan;67(1):170. No abstract available.
PMID: 3968099 [PubMed - indexed for MEDLINE]

37
Malaguti M, Triolo L, Biagini M.
Ciprofloxacin-associated Achilles tendon rupture in a hemodialysis patient.
J Nephrol. 2001 Sep-Oct;14(5):431-2. No abstract available.
PMID: 11730281 [PubMed - indexed for MEDLINE]

38
Cetti R, Christensen SE.
[Rupture of the Achilles tendon after local steroid injection]
Ugeskr Laeger. 1982 May 10;144(19):1392. Danish. No abstract available.
PMID: 7135524 [PubMed - indexed for MEDLINE]

39
Poon CC, Sundaram NA.
Spontaneous bilateral Achilles tendon rupture associated with ciprofloxacin.
Med J Aust. 1997 Jun 16;166(12):665. No abstract available.
PMID: 9216589 [PubMed - indexed for MEDLINE]

40
Dekens-Konter JA, Knol A, Olsson S, Meyboom RH, de Koning GH.
[Tendinitis of the Achilles tendon caused by pefloxacin and other
fluoroquinolone derivatives]
Ned Tijdschr Geneeskd. 1994 Mar 5;138(10):528-31. Dutch.
PMID: 8139714 [PubMed - indexed for MEDLINE]

41
Breck RW.
"Ciprofloxacin: a warning for clinicians".
Conn Med. 2002 Oct;66(10):635. No abstract available.
PMID: 12448217 [PubMed - indexed for MEDLINE]

42
Gibbon WW, Cooper JR, Radcliffe GS.
Sonographic incidence of tendon microtears in athletes with chronic Achilles tendinosis.
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202
Amendola N.
Surgical treatment of acute rupture of the tendo Achillis led to fewer
reruptures and better patient-generated ratings than did nonsurgical treatment.
J Bone Joint Surg Am. 2002 Feb;84-A(2):324. No abstract available.
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203
Zwar RB.
Utility of musculoskeletal ultrasound.
Aust Fam Physician. 2002 Jun;31(6):559, 561.
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204
Cottrell WC, Pearsall AW 4th, Hollis MJ.
Simultaneous tears of the Achilles tendon and medial head of the gastrocnemius muscle.
Orthopedics. 2002 Jun;25(6):685-7. No abstract available.
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207
Forslund C.
BMP treatment for improving tendon repair. Studies on rat and rabbit Achilles tendons.
Acta Orthop Scand Suppl. 2003 Feb;74(308):I, 1-30. No abstract available.
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211
Fama U, Irace S, Frati R, de Gado F, Scuderi N.
Is it a real risk to take ciprofloxacin?
Plast Reconstr Surg. 2004 Jul;114(1):267. No abstract available.
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212
Richardson LC, Reitman R, Wilson M.
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Foot Ankle Int. 2003 May;24(5):439-43.
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213
Pierfitte C, Royer RJ.
Tendon disorders with fluoroquinolones.
Therapie. 1996 Jul-Aug;51(4):419-20. No abstract available.
PMID: 8953821 [PubMed - indexed for MEDLINE]

214
Royer RJ, Pierfitte C, Netter P.
Features of tendon disorders with fluoroquinolones.
Therapie. 1994 Jan-Feb;49(1):75-6. No abstract available.
PMID: 8091374 [PubMed - indexed for MEDLINE]

215
Gotoh M, Higuchi F, Suzuki R, Yamanaka K.
Progression from calcifying tendinitis to rotator cuff tear.
Skeletal Radiol. 2003 Feb;32(2):86-9. Epub 2002 Apr 05.
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218
Pedros A, Emilio Gomez J, Angel Navarro L, Tomas A.
[Levofloxacin and acute confusional syndrome]
Med Clin (Barc). 2002 Jun 8;119(1):38-9. Spanish. No abstract available.
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219
Manoj Kumar RV, Rajasekaran S.
Spontaneous tendon ruptures in alkaptonuria.
J Bone Joint Surg Br. 2003 Aug;85(6):883-6.
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220
Maffulli N, Kader D.
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J Bone Joint Surg Br. 2002 Jan;84(1):1-8. Review. No abstract available.
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221
Harris RD, Nindl G, Balcavage WX, Weiner W, Johnson MT.
Use of proteomics methodology to evaluate inflammatory protein expression in tendinitis.
Biomed Sci Instrum. 2003;39:493-9.
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222
Milgrom C, Finestone A, Zin D, Mandel D, Novack V.
Cold weather training: a risk factor for Achilles paratendinitis among
recruits.
Foot Ankle Int. 2003 May;24(5):398-401.
PMID: 12801195 [PubMed - indexed for MEDLINE]

223
Schwalm JD, Lee CH.  
Acute hepatitis associated with oral levofloxacin therapy in a hemodialysis patient.
CMAJ. 2003 Apr 1;168(7):847-8.
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224
Oh YR, Carr-Lopez SM, Probasco JM, Crawley PG.
Levofloxacin-induced autoimmune hemolytic anemia.
Ann Pharmacother. 2003 Jul-Aug;37(7-8):1010-3.
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228
Bardin L.
Comments on 'Achilles tendinopathy'.
Man Ther. 2003 Aug;8(3):189; author reply 190-1. No abstract available.
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229
Ackermann PW, Li J, Lundeberg T, Kreicbergs A.
Neuronal plasticity in relation to nociception and healing of rat achilles tendon.
J Orthop Res. 2003 May;21(3):432-41.
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230
Sidorenko SV, Krivitskaia NS
[Use of ciprofloxacin in sequential antibiotic therapy]
Antibiot Khimioter. 2002;47(7):25-30. Review. Russian. No abstract available.
PMID: 12516193 [PubMed - indexed for MEDLINE]

234
Paavola M, Kannus P, Jarvinen TA, Khan K, Jozsa L, Jarvinen M.
Achilles tendinopathy.
J Bone Joint Surg Am. 2002 Nov;84-A(11):2062-76. Review. No abstract available.
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246
Mason JO, Meagher DJ, Sheehan B, O'Doherty CK.
The management of supraspinatus tendinitis in general practice.
Ir Med J. 1980 Jan;73(1):23-40. No abstract available.
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247
Ho DY, Song JC, Wang CC.
Anaphylactoid reaction to ciprofloxacin.
Ann Pharmacother. 2003 Jul-Aug;37(7-8):1018-23.
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254
Ying M, Yeung E, Li B, Li W, Lui M, Tsoi CW.
Sonographic evaluation of the size of Achilles tendon: the effect of exercise and dominance of the ankle.
Ultrasound Med Biol. 2003 May;29(5):637-42.
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261
Cook J, Khan K.
The treatment of resistant, painful tendinopathies results in frustration for athletes and health professionals alike.
Am J Sports Med. 2003 Mar-Apr;31(2):327-8; author reply 328. No abstract available.
PMID: 12642274 [PubMed - indexed for MEDLINE]

262
[No authors listed]
Fluoroquinolones in ambulatory ENT and respiratory tract infections: rarely appropriate.
Prescrire Int. 2003 Feb;12(63):26-7.
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265
Roberts C, Deliss L.:
Acute rupture of tendo Achillis.
J Bone Joint Surg Br. 2002 May;84(4):620; author reply 620. No abstract available.
PMID: 12043793 [PubMed - indexed for MEDLINE]

266
Paffey MD, Faraj AA.
Acute rupture of tendo Achillis.
J Bone Joint Surg Br. 2002 May;84(4):620-1; author reply 621. No abstract available.
PMID: 12043792 [PubMed - indexed for MEDLINE]

267
DE VRIES AC.