Adverse Testicular effects in rats?

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Pharmacol Res 2000 Feb;41(2):211-9 Related Articles,

Adverse testicular effects of some quinolone members in rats.

Abd-Allah AR, Aly HA, Moustafa AM, Abdel-Aziz AA, Hamada FM

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.

In the last few years, a marked decrease in male fertility has been
reported. Environmental factors were recently suspected for this
effect. Among those factors is the misuse of drugs and in particular
antibiotics.Quinolones are a group of antibacterial agents with
 broad- spectrum activity. Testicular impairment of some quinolone members is controversial; a matter which stimulated our attention to investigate the adverse testicular effects of the most familiar quinolone members, namely: ofloxacin, ciprofloxacin and pefloxacin. They were given to rats in doses of 72, 135 and 72 mg kg(-1)day(-1) p.o., respectively, for 15 consecutive days. Ofloxacin was also used to establish a dose-response relationship in doses of 36, 72 and 360 mg kg(-1) day(-1) p.o. for 15 consecutive days. Results revealed that ofloxacin, ciprofloxacin and pefloxacin reduced testicular LDH-X activity by 39.8%, 62.7% and 60.7%, respectively.