The Fluoroquinolone Toxicity Research Foundation

 

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  TENS, SJS, Phototoxicity and Skin Damage Research   See downloads for: Adobe Files


 Photolocalized purpura during ciprofloxacin therapy.

Ciprofloxacin-induced acute generalized exanthematous pustulosis mimicking bullous drug eruption confirmed by a positive patch test.

Gatifloxacin-induced Purpura –
An Unusual Adverse Drug Reaction
Imrana Masood, R Bhargava, Zuber Ahmed, DK Sharma, SZ Rehman, SS Amin: JIACM 2005; 6(3): 239-40

Ofloxacin induced Sweet's syndrome in a patient with Crohn's disease. Ozdemir D, Korkmaz U, Sahin I, Sencan I, Kavak A, Kucukbayrak A, Cakir S.

Multiple fixed drug eruption due to drug combination. (PL and Levaquin) Yokoyama A, Hara H.

Severe vision damage after possible Ciprofloxacin induced T.E.N.S.

Case Report
Ciprofloxacin-Induced Toxic Epidermal Necrolysis in a Patient with Systemic Lupus Erythematosus
M. Jongen-Lavrencic1, P. M. Schneeberger2 and J. G. van der Hoeven3
 

Pharmacotherapy. 2002 Jun;22(6):789-93.
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.
Digwood-Lettieri S, Reilly KJ, Haith LR Jr, Patton ML, Guilday RJ, Cawley MJ, Ackerman BH.

Ann Pharmacother. 2001 Nov;35(11):1388-90.
Ofloxacin: a probable cause of toxic epidermal necrolysis.
Melde SL.

Ann Pharmacother. 2005 May;39(5):953-5. Epub 2005 Apr 12. Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure.
Christie MJ, Wong K, Ting RH, Tam PY, Sikaneta TG.

Norfloxacin-induced toxic epidermal necrolysis. Sahin MT, Ozturkcan S, Inanir I, Filiz EE. Medical Faculty, Department of Dermatology, Celal Bayar University, Manisa, Turkey. mustafaturhan@superonline.com

Induced and Photoinduced DNA Damage by Quinolones: Ciprofloxacine, Ofloxacine and Nalidixic Acid determined by Comet Assay. Sanchez G, Hidalgo ME, Vivanco JM, Escobar J. Universidad de Valparaiso.

Ciprofloxacin-induced vasculitis with cutaneous and renal involvement

In vitro method for prediction of the phototoxic potentials of fluoroquinolones.

Acute pustular psoriases complicated by leukocytoclastic vasculitis

Within the drug monographs as well as the literature we find NUMEROUS citations in which fluoroquinolone vasculitis is cited

Allergic contact dermatitis from laboratory synthesis of 4-bromomethyl-6,8-dimethyl-2(1H)-quinolone.
Rycroft RJ.

Quinolone antibacterials: a new class of photochemical carcinogens.

Ofloxacin: a probable cause of toxic epidermal necrolysis

Norfloxacin-Induced Toxic Epidermal Necrolysis

Ciprofloxacin-induced toxic epidermal necrolysis

[New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones] [Article in Japanese] Hayashi N. New Lead Pharmacology Laboratory, Institute for Medical Research, Wakunaga Pharmaceutical Co., Ltd., Akitakata City 739-1195, Japan. hayashi_n@wakunaga.co.jp

Sweet ’s syndrome (acute febrile neutrophilic dermatosis) associated with norfloxacin in a prostate cancer patient

Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis
Tina Papastavros, Lisa R. Dolovich, Anne Holbrook, Lori Whitehead, and Mark Loeb

[New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones] [Article in Japanese]
Hayashi N.
New Lead Pharmacology Laboratory, Institute for Medical Research, Wakunaga Pharmaceutical Co., Ltd., Akitakata City 739-1195, Japan. hayashi_n@wakunaga.co.jp

 


Livasy CA, Kaplan AM: Ciprofloxacin-induced toxic epidermal necrolysis: a case report. Dermatology 1997;195(2):173-175.
No Abstract or Article available at this time.

LETTERS TO THE EDITOR
Sparfloxacin-related vascular purpura,
D. smith, n. bernard, ph. morlat, b. begaud, j. beylot
BMJ. 1989 Sep 9;299(6700):658.
No Abstract or Article available at this time.



From Pubmed/Medline

Phototoxicity (26)

1    Hayashi N, Nakata Y, Yazaki A.New findings on the structure-phototoxicity relationship and photostability of fluoroquinolones with various substituents at position 1.
Antimicrob Agents Chemother. 2004 Mar;48(3):799-803.
PMID: 14982767 [PubMed - indexed for MEDLINE]

2    Miolo G, Viola G, Vedaldi D, Dall'Acqua F, Fravolini A, Tabarrini O, Cecchetti V.In vitro phototoxic properties of new 6-desfluoro and 6-fluoro-8-methylquinolones.
Toxicol In Vitro. 2002 Dec;16(6):683-93.
PMID: 12423651 [PubMed - indexed for MEDLINE]

3     Moore DE.Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management.
Drug Saf. 2002;25(5):345-72. Review.
PMID: 12020173 [PubMed - indexed for MEDLINE]

4      Sun YW, Heo EP, Cho YH, Bark KM, Yoon TJ, Kim TH.Pefloxacin and ciprofloxacin increase UVA-induced edema and immune suppression.
Photodermatol Photoimmunol Photomed. 2001 Aug;17(4):172-7.
PMID: 11499539 [PubMed - indexed for MEDLINE]

6     Kidd S, Meunier JR, Traynor NJ, Marrot L, Agapakis-Causse C, Gibbs NK.The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells.
J Photochem Photobiol B. 2000 Oct;58(1):26-31.
PMID: 11195849 [PubMed - indexed for MEDLINE]

7     Ouedraogo G, Morliere P, Santus R, Miranda, Castell JV.Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones.
J Photochem Photobiol B. 2000 Oct;58(1):20-5.
PMID: 11195848 [PubMed - indexed for MEDLINE]

8    [No authors listed]Drug-induced cutaneous photosensitivity: some drugs warrant routine precautions.
Prescrire Int. 2000 Aug;9(48):117-22.
PMID: 11067725 [PubMed - indexed for MEDLINE]

9     Shimoda K, Ikeda T, Okawara S, Kato M.Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice.
Toxicol Sci. 2000 Aug;56(2):290-6.
PMID: 10910986 [PubMed - indexed for MEDLINE]

10     Pierfitte C, Royer RJ, Moore N, Begaud B.The link between sunshine and phototoxicity of sparfloxacin.
Br J Clin Pharmacol. 2000 Jun;49(6):609-12.
PMID: 10848726 [PubMed - indexed for MEDLINE]

11    Oliveira HS, Goncalo M, Figueiredo AC.Photosensitivity to lomefloxacin. A clinical and photobiological study.
Photodermatol Photoimmunol Photomed. 2000 Jun;16(3):116-20.
PMID: 10885440 [PubMed - indexed for MEDLINE]

12    Man I, Murphy J, Ferguson J.Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers.
J Antimicrob Chemother. 1999 May;43 Suppl B:77-82.
PMID: 10382879 [PubMed - indexed for MEDLINE]

13    Makinen M, Forbes PD, Stenback F.Quinolone antibacterials: a new class of photochemical carcinogens.
J Photochem Photobiol B. 1997 Feb;37(3):182-7.
PMID: 9085565 [PubMed - indexed for MEDLINE]

14     Klecak G, Urbach F, Urwyler H.Fluoroquinolone antibacterials enhance UVA-induced skin tumors.
J Photochem Photobiol B. 1997 Feb;37(3):174-81.
PMID: 9085564 [PubMed - indexed for MEDLINE]

15    Urbach F.Phototoxicity and possible enhancement of photocarcinogenesis by fluorinated quinolone antibiotics.
J Photochem Photobiol B. 1997 Feb;37(3):169-70. Review. No abstract available.
PMID: 9085562 [PubMed - indexed for MEDLINE]

16    Shimoda K, Akahane K, Nomura M, Kato M.LD50 value, phototoxicity and convulsion induction test of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acid hemihydrate in laboratory animals.
Arzneimittelforschung. 1996 Jun;46(6):625-8.
PMID: 8767355 [PubMed - indexed for MEDLINE]

17    Kimura M, Kawada A, Kobayashi T, Hiruma M, Ishibashi A.Photosensitivity induced by fleroxacin.
Clin Exp Dermatol. 1996 Jan;21(1):46-7.
PMID: 8689769 [PubMed - indexed for MEDLINE]

18    Correia O, Delgado L, Barros MA.Bullous photodermatosis after lomefloxacin.
Arch Dermatol. 1994 Jun;130(6):808-9. No abstract available.
PMID: 8002662 [PubMed - indexed for MEDLINE]

19     Kurumaji Y, Shono M.Drug-induced solar urticaria due to repirinast.
Dermatology. 1994;188(2):117-21.
PMID: 8136537 [PubMed - indexed for MEDLINE]

20    Shimoda K, Yoshida M, Wagai N, Takayama S, Kato M.Phototoxic lesions induced by quinolone antibacterial agents in auricular skin and retina of albino mice.
Toxicol Pathol. 1993 Nov-Dec;21(6):554-61.
PMID: 8052802 [PubMed - indexed for MEDLINE]

21   Kang JS, Kim TH, Park KB, Chung BH, Youn JI.Enoxacin photosensitivity.
Photodermatol Photoimmunol Photomed. 1993 Aug;9(4):159-61.
PMID: 8318434 [PubMed - indexed for MEDLINE]

22    Scheife RT, Cramer WR, Decker EL.Photosensitizing potential of ofloxacin.
Int J Dermatol. 1993 Jun;32(6):413-6.
PMID: 8320021 [PubMed - indexed for MEDLINE]

23    Izu R, Gardeazabal J, Gonzalez M, Landa N, Raton JA, Diaz-Perez JL.Enoxacin-induced photosensitivity: study of two cases.
Photodermatol Photoimmunol Photomed. 1992 Apr;9(2):86-8.
PMID: 1489723 [PubMed - indexed for MEDLINE]

24    Wagai N, Tawara K.Possible direct role of reactive oxygens in the cause of cutaneous phototoxicity induced by five quinolones in mice.
Arch Toxicol. 1992;66(6):392-7.
PMID: 1332649 [PubMed - indexed for MEDLINE]

25   Wagai N, Yamaguchi F, Sekiguchi M, Tawara K.Phototoxic potential of quinolone antibacterial agents in Balb/c mice.
Toxicol Lett. 1990 Dec;54(2-3):299-308.
PMID: 2260126 [PubMed - indexed for MEDLINE]

26    Ferguson J, Johnson BE.Ciprofloxacin-induced photosensitivity: in vitro and in vivo studies.
Br J Dermatol. 1990 Jul;123(1):9-20.
PMID: 2202428 [PubMed - indexed for MEDLINE]

Dermatology (13)

1    Digwood-Lettieri S, Reilly KJ, Haith LR Jr, Patton ML, Guilday RJ, Cawley MJ, Ackerman BH.Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.
Pharmacotherapy. 2002 Jun;22(6):789-93.
PMID: 12066972 [PubMed - indexed for MEDLINE]

2     Anadolu RY, Birol A, Bostanci S, Boyvatt A.A case of pemphigus vulgaris possibly triggered by quinolones.
J Eur Acad Dermatol Venereol. 2002 Mar;16(2):152-3.
PMID: 12046820 [PubMed - indexed for MEDLINE]

3    Melde SL.Ofloxacin: a probable cause of toxic epidermal necrolysis.
Ann Pharmacother. 2001 Nov;35(11):1388-90.
PMID: 11724089 [PubMed - indexed for MEDLINE]

4     Rodriguez-Morales A, Llamazares AA, Benito RP, Cocera CM.Fixed drug eruption from quinolones with a positive lesional patch test to ciprofloxacin.
Contact Dermatitis. 2001 Apr;44(4):255. No abstract available.
PMID: 11336009 [PubMed - indexed for MEDLINE]

5    Sangen Y, Kawada A, Asai M, Aragane Y, Yudate T, Tezuka T.Fixed drug eruption induced by tosufloxacin tosilate.
Contact Dermatitis. 2000 May;42(5):285. No abstract available.
PMID: 10789850 [PubMed - indexed for MEDLINE]

6    Matthews MR, Caruso DM, Phillips BJ, Csontos LG.Fulminant toxic epidermal necrolysis induced by trovafloxacin.
Arch Intern Med. 1999 Oct 11;159(18):2225. No abstract available.
PMID: 10527301 [PubMed - indexed for MEDLINE]

7    Triller DM, Miller MT, Briceland LL, Gordon FS.Trovafloxacin-associated exfoliative dermatitis in a homecare patient.
Ann Pharmacother. 1999 Oct;33(10):1122. No abstract available.
PMID: 10534226 [PubMed - indexed for MEDLINE]

8    Hamanaka H, Mizutani H, Asahig K, Shimizu M.J Dermatol Sci. 1999 Sep;21(1):27-33.
PMID: 10468189 [PubMed - indexed for MEDLINE]

9    ijima S, Nakagawa M.Fixed drug eruption caused by tosufloxacin tosilate.
J Int Med Res. 1997 Nov-Dec;25(6):359-63.
PMID: 9427169 [PubMed - indexed for MEDLINE]

10    Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, et al.Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.
N Engl J Med. 1995 Dec 14;333(24):1600-7.
PMID: 7477195 [PubMed - indexed for MEDLINE]

11    Kurata M, Kasuga Y, Nanba E, Nakamura H, Asano T, Haruta K.Flush induced by fluoroquinolones in canine skin.
Inflamm Res. 1995 Nov;44(11):461-5.
PMID: 8597878 [PubMed - indexed for MEDLINE]

12    Drago F, Arditi MR, Rebora A.Henoch-Schonlein purpura induced by fluoroquinolones.
Br J Dermatol. 1994 Sep;131(3):448. No abstract available.
PMID: 7918022 [PubMed - indexed for MEDLINE]

13    Moshfeghi M, Mandler HD.Ciprofloxacin-induced toxic epidermal necrolysis.
Ann Pharmacother. 1993 Dec;27(12):1467-9.
PMID: 8305780 [PubMed - indexed for MEDLINE]