DEPERSONALIZATION / MENTAL ILLNESS

Gatifloxacin-Induced Hallucinations in a 19-Year-Old Man

Concomitant Use of NSAIDs With Norfloxacin (Noroxin) May Increase Seizure Risk

Orofacial dyskinesia after ofloxacin treatment.

Posted: 6/14/2005 8:02:30 PM  Today Eyewitness News talked to a man who says "Cipro" caused him to go crazy. Vince Mule´ says his doctors have even confirmed that it was "Cipro" that caused his irrational behavior. "

Cipro Induced Psychosis
A case of ciprofloxacin-induced acute polymorphic psychosis with a distinct deficit of the executive functions
Grimm, Dr. Oliver and Alm, Dr. Barbara (2005)

Family Says Medication Led to Son's Rampage.  Family members say Brewer had been taking Cipro for about two weeks after toe surgery.

Prolonged Electroconvulsive Therapy Seizure in a Patient Taking Ciprofloxacin. Journal of ECT. 21(1):43-44, March 2005.
Kisa, Cebrail MD; Yildirim, Sema G MD; Aydemir, Cigdem MD; Cebeci, Sevsen MD; Goka, Erol MD
"...the extended seizure in this patient is thought to be related to ciprofloxacin..."

Antimicrobial-induced mania (antibiomania): a review of spontaneous reports. Abouesh A, Stone C, Hobbs WR.

Gatifloxacin Precipitation of Psychosis in Alzheimer Disease
Roy R. Reeves, D.O., Ph.D.


Delirium Associated With Gatifloxacin
C. Loraine Sumner, B.A., and Richard L. Elliott, M.D., Ph.D., F.A.P.A., Macon, Ga
.

Ciprofloxacin-induced oral facial dyskinesia in a patient with normal liver and renal function.

Ciprofloxacin-induced chorea.
Azar S, Ramjiani A, Van Gerpen JA.
Mov Disord. 2005 Feb 28; [Epub ahead of print]
PMID: 15739219 [PubMed - as supplied by publisher]

General pharmacology of the new quinolone antibacterial agent levofloxacin.
  Takasuna K, Kasai Y, Usui C, Takahashi M, Hirohashi M, Tamura K, Takayama S.  Drug Safety Research Center, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.

Levofloxacin-induced-neurological adverse events such as convulsion, involuntary movement (tremor, myoclonus and chorea like), visual hallucination in two elderly patients
Nippon Ronen Igakkai Zasshi. 1999 Mar;36(3):213-7.

Levofloxacin-induced delirium.
Clin Neurol Neurosurg. 2005 Feb;107(2):158-9.

The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown

Neuropsychiatric manifestations and quinolones. Apropos of a case

Seizures Associated with Fluoroquinolones

Neural-immune interactions in health and disease

Seizures Associated with Fluoroquinolones

Psychotic reactions during administration of quinolones
Ned Tijdschr Geneeskd. 1994 May 21;138(21):1080-2.
[Article in Dutch]


Neurochemical studies on quinolone antibiotics: effects on glutamate, GABA and adenosine systems in mammalian CNS.

Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations.

Possible gatifloxacin-induced seizure.
Quigley CA, Lederman JR.
Department of Pharmacy Practice, College of Pharmacy, Midwestern University Chicago, Downers Grove, IL 60515-1235, USA. cquigl@midwestern.edu


Adverse events associated with pyrazinamide and levofloxacin in the treatment of latent multidrug-resistant tuberculosis
Tina Papastavros, Lisa R. Dolovich, Anne Holbrook, Lori Whitehead, and Mark Loeb

Quinolone Induced Psychosis

Generalized seizure and toxic epidermal necrolysis following levofloxacin exposure.
Christie MJ, Wong K, Ting RH, Tam PY, Sikaneta TG.
University of Toronto, Nephrology Associates, Scarborough, Ontario, Canada, and Scarborough General Hospital, Scarborough.

Additional References


The following citations have no abstract.  The full text can be purchased from the links provide or by contacting the author or the publication cited:

Arch Intern Med. 2001 Oct 8;161(18):2261-2.
Myoclonus and generalized seizures associated with gatifloxacin treatment.
Marinella MA.
Dayton, Ohio.
http://archinte.ama-assn.org/cgi/content/full/161/18/2261


Additional Research from PubMed/Medline

Psychiatric (25)

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Ann Pharmacother. 2004 Feb;38(2):235-7. Epub 2003 Dec 15.
PMID: 14742757 [PubMed - indexed for MEDLINE]

2    Skretkowicz J, Gondko A.[Fluoroquinolones interactions with nonsteroidal anti-inflammatory drugs]
Pol Merkuriusz Lek. 2004 Feb;16(92):194-5. Review. Polish.
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3    Shattell M, Keltner NL.The case for atypical antipsychotics in bipolar disorder.
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4    Hori S, Kizu J, Kawamura M.Effects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugs.
J Infect Chemother. 2003 Dec;9(4):314-20.
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5    [No authors listed]Mania induced by antimicrobial agents: mainly isoniazid, clarithromycin and fluoroquinolones.
Prescrire Int. 2003 Oct;12(67):183. No abstract available.
PMID: 14619905 [PubMed - indexed for MEDLINE]

6    Reeves RR.Gatifloxacin precipitation of psychosis in Alzheimer disease.
Am J Geriatr Psychiatry. 2003 Jul-Aug;11(4):470-1. No abstract available.
PMID: 12837678 [PubMed - indexed for MEDLINE]

7    Sumner CL, Elliott RL.Delirium associated with gatifloxacin.
Psychosomatics. 2003 Jan-Feb;44(1):85-6. No abstract available.
PMID: 12515846 [PubMed - indexed for MEDLINE]

8    Kushner JM, Peckman HJ, Snyder CR.Seizures associated with fluoroquinolones.
Ann Pharmacother. 2001 Oct;35(10):1194-8. Review.
PMID: 11675843 [PubMed - indexed for MEDLINE]

9     Melvani S, Speed BR.Alatrofloxacin-induced seizures during slow intravenous infusion.
Ann Pharmacother. 2000 Sep;34(9):1017-9.
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10    Kundu AK.Norfloxacin-induced hallucination--an unusual CNS toxicity of 4-fluoroquinolones.
J Assoc Physicians India. 2000 Sep;48(9):944. No abstract available.
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11    Hori S.[A study on the mechanism of seizures associated with the drug interaction between quinolones and anti-inflammatory drugs. A comparative study and the structure-activity relationship of anti-inflammatory drugs]
Jpn J Antibiot. 2000 Apr;53(4):249-52. Japanese. No abstract available.
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Natl Med J India. 2000 Jan-Feb;13(1):47. No abstract available.
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13    Farooq S, Khawaja MY.Fever and acute brief psychosis in developing countries.
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Br J Clin Pharmacol. 1998 Jan;45(1):77-81.
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15    Walton GD, Hon JK, Mulpur TG.Ofloxacin-induced seizure.
Ann Pharmacother. 1997 Dec;31(12):1475-7.
PMID: 9416384 [PubMed - indexed for MEDLINE]

16     Shiosaki K, Asin KE, Britton DR, Giardina WJ, Bednarz L, Mahan L, Mikusa J, Nikkel A, Wismer C.Hyperactivity and behavioral seizures in rodents following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Eur J Pharmacol. 1996 Dec 19;317(2-3):183-90.
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17    Feinberg SS.Fluoroquinolone-induced depression.
Am J Psychiatry. 1995 Jun;152(6):954-5. No abstract available.
PMID: 7755134 [PubMed - indexed for MEDLINE]

18    Ross DL, Riley CM.Dissociation and complexation of the fluoroquinolone antimicrobials--an update.
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PMID: 7841230 [PubMed - indexed for MEDLINE]

19    Salm EF, Egberts AC, Maartense E, Hart W, Stricker BH.[Psychotic reactions during administration of quinolones]
Ned Tijdschr Geneeskd. 1994 May 21;138(21):1080-2. Dutch.
PMID: 8202181 [PubMed - indexed for MEDLINE]

20    De Sarro A, Zappala M, Chimirri A, Grasso S, De Sarro GB.Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.
Antimicrob Agents Chemother. 1993 Jul;37(7):1497-503.
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21    Reeves RR.Ciprofloxacin-induced psychosis.
Ann Pharmacother. 1992 Jul-Aug;26(7-8):930-1.
PMID: 1504404 [PubMed - indexed for MEDLINE]

22    Rampa S, Caroli F.[Neuropsychiatric manifestations and quinolones. Apropos of a case]
Encephale. 1991 Nov-Dec;17(6):511-4. French.
PMID: 1666873 [PubMed - indexed for MEDLINE]

23    Motomura M, Kataoka Y, Takeo G, Shibayama K, Ohishi K, Nakamura T, Niwa M, Tsujihata M, Nagataki S.Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.
Int J Clin Pharmacol Ther Toxicol. 1991 Jun;29(6):223-7.
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J Toxicol Clin Exp. 1990 Nov-Dec;10(7-8):469-72. French.
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25.     Levofloxacin-induced delirium: Diagnostic considerations.
Fernandez-Torre JL.
Clin Neurol Neurosurg. 2006 Sep;108(6):614. Epub 2005 Apr 15. No abstract available.

Nuerological (25)

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South Med J. 2000 May;93(5):514-5.
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2    Kim MK, Nightingale C, Nicolau D.Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine.
Clin Pharmacokinet. 2003;42(11):985-96.
PMID: 12908854 [PubMed - indexed for MEDLINE]

3    Sieb JP.Fluoroquinolone antibiotics block neuromuscular transmission.
Neurology. 1998 Mar;50(3):804-7.
PMID: 9521283 [PubMed - indexed for MEDLINE]

4    Carbo M, Segura J, De la Torre R, Badenas JM, Cami J.Effect of quinolones on caffeine disposition.
Clin Pharmacol Ther. 1989 Mar;45(3):234-40.
PMID: 2920498 [PubMed - indexed for MEDLINE]

5    Galland MC, Jouve-Bestagne MH, Rodor F, Jouglard J.Neurologic side effects of quinolones]
Therapie. 1982 Jul-Aug;37(4):481-7. French. No abstract available.
PMID: 7135332 [PubMed - indexed for MEDLINE]

6     Harder S, Fuhr U, Staib AH, Wolff T.Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations.
Am J Med. 1989 Nov 30;87(5A):89S-91S.
PMID: 2589393 [PubMed - indexed for MEDLINE]

7    Bowie WR, Willetts V, Jewesson PJ.Adverse reactions in a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin.
Antimicrob Agents Chemother. 1989 Oct;33(10):1778-82.
PMID: 2511802 [PubMed - indexed for MEDLINE]
Adverse reactions developed in 66 (84%) of 79 individuals, and severe reactions arose in 38 (48%). Most frequent were central nervous system reactions (70%), with insomnia being especially frequent (49%); gastrointestinal reactions (39%) and photosensitivity reactions (10%) were also common

8    Stille W, Harder S, Mieke S, Beer C, Shah PM, Frech K, Staib AH.Decrease of caffeine elimination in man during co-administration of 4-quinolones.
J Antimicrob Chemother. 1987 Nov;20(5):729-34.
PMID: 3480885 [PubMed - indexed for MEDLINE]

9     Staib AH, Stille W, Dietlein G, Shah PM, Harder S, Mieke S, Beer C.Interaction between quinolones and caffeine.
Drugs. 1987;34 Suppl 1:170-4.
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10    Kaneda M, Tsuda J, Iida N, Igarashi T, Tajima H, Kizu J, Hori S.[Surveillance on concurrent administration of quinolones and anti-inflammatory drugs in a community hospital]
Jpn J Antibiot. 2003 Aug;56(4):272-80. Japanese.
PMID: 14567251 [PubMed - indexed for MEDLINE]

11    Aoun M, Jacquy C, Debusscher L, Bron D, Lehert M, Noel P, van der Auwera P.Peripheral neuropathy associated with fluoroquinolones.
Lancet. 1992 Jul 11;340(8811):127. No abstract available.
PMID: 1352007 [PubMed - indexed for MEDLINE]

12    Giardina WJ.Assessment of temafloxacin neurotoxicity in rodents.
Am J Med. 1991 Dec 30;91(6A):42S-44S.
PMID: 1662895 [PubMed - indexed for MEDLINE]

13    Thomas RJ, Reagan DR.Association of a Tourette-like syndrome with ofloxacin.
Ann Pharmacother. 1996 Feb;30(2):138-41.
PMID: 8835045 [PubMed - indexed for MEDLINE]

14     Mahr G, Sorgel F, Granneman GR, Kinzig M, Muth P, Patterson K, Fuhr U, Nickel P, Stephan U.Effects of temafloxacin and ciprofloxacin on the pharmacokinetics of caffeine.
Clin Pharmacokinet. 1992;22 Suppl 1:90-7.
PMID: 1319876 [PubMed - indexed for MEDLINE]

15   Stoppe G, Ruther E.[Central nervous system side effects of different antibacterial substances]
Infection. 1991;19 Suppl 1:S29-32. Review. German.
PMID: 2007512 [PubMed - indexed for MEDLINE]

16   Christ W.Central nervous system toxicity of quinolones: human and animal findings.
J Antimicrob Chemother. 1990 Oct;26 Suppl B:219-25.
PMID: 2124211 [PubMed - indexed for MEDLINE]

17    Hedenmalm K, Spigset O.Peripheral sensory disturbances related to treatment with fluoroquinolones.
J Antimicrob Chemother. 1996 Apr;37(4):831-7.
PMID: 8722551 [PubMed - indexed for MEDLINE]

18    Thomas RJ.Neurotoxicity of antibacterial therapy.
South Med J. 1994 Sep;87(9):869-74. Review.
PMID: 8091248 [PubMed - indexed for MEDLINE]

19    Menzies D, Klein NC, Cunha BA.Trovafloxacin neurotoxicity.
Am J Med. 1999 Sep;107(3):298-9. No abstract available.
PMID: 10492332 [PubMed - indexed for MEDLINE]

20    Hori S, Kageyama S.Quinolones and their central nervous system toxicities]
Ryoikibetsu Shokogun Shirizu. 1999;(27 Pt 2):552-7. Review. Japanese. No abstract available.
PMID: 10434720 [PubMed - indexed for MEDLINE]

21   Guiol C, Ledoussal C, Surge JM.Pharmacological properties of a new fluoroquinolone on the central nervous system in rodents.
Arzneimittelforschung. 1993 Jan;43(1):56-60.
PMID: 8447850 [PubMed - indexed for MEDLINE]

22   Ichikawa N, Naora K, Hayashibara M, Katagiri Y, Iwamoto K.Effect of fenbufen on the entry of new quinolones, norfloxacin and ofloxacin, into the central nervous system in rats.
J Pharm Pharmacol. 1992 Nov;44(11):915-20.
PMID: 1361537 [PubMed - indexed for MEDLINE]

23   Tillotson GS.Comment: peripheral neuropathy syndrome and fluoroquinolones.
Ann Pharmacother. 2001 Dec;35(12):1673-4. No abstract available.
PMID: 11793644 [PubMed - indexed for MEDLINE]

24    Cohen JS.Peripheral neuropathy associated with fluoroquinolones.
Ann Pharmacother. 2001 Dec;35(12):1540-7.
PMID: 11793615 [PubMed - indexed for MEDLINE]

25    Thiel R, Metzner S, Gericke C, Rahm U, Stahlmann R.Effects of fluoroquinolones on the locomotor activity in rats.
Arch Toxicol. 2001 Mar;75(1):36-41.
PMID: 11357519 [PubMed - indexed for MEDLINE]

26.  Schmuck G, Schurmann A, Schluter G.
Determination of the excitatory potencies of fluoroquinolones in the central nervous system by an in vitro model.
Antimicrob Agents Chemother. 1998 Jul;42(7):1831-6. Erratum in: Antimicrob Agents Chemother 1998 Sep;42(9):2465.
PMID: 9661029 [PubMed - indexed for MEDLINE]
(article in which Bayer admits CNS adverse reactions)


 Additional Resources

 http://www.remcomp.fr/asmanet/bira-95.html

http://www.urmc.rochester.edu/gebs/faculty/john_Hansen.htm

http://www.sobs.soton.ac.uk/staff/hp.html

http://www.soton.ac.uk/~cig/

http://www.dartmouth.edu/dms/mdphd/cairn_fall99/section3.html

http://neuroscience.nih.gov/Lab.asp?Org_ID=191