neurotoxic effects of the fluoroquinolones

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DISCUSSION: The reported neurotoxic effects of the fluoroquinolones include insomnia, seizures, delirium, and psychosis, best explained by the gamma-aminobutyric acid-antagonistic properties of this class of drugs. (quinolones are known as gaba inhibitors so have the ability to bind to neurorecptor sites).

Several hypotheses have been proposed to explain the development of these cases of tendinopathy: immuno-allergic mechanisms, direct toxicity of the molecule on collagen fibres, cell-mediated oxidative aggression, or tendon necrosis due to vascular mechanisms.

Toxicol In Vitro 2001 Dec;15(6):721-7