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Non-Fatal Acute Liver Injury
Possibly Related to High-Dose Ciprofloxacin Mechanistic Study
on Flumequine Hepatocarcinogenicity Focusing on DNA Damage in Mice
Yoko Kashida*, Yu F. Sasaki, Koh-ichi Ohsawa, Natsue Yokohama, Akiko
Takahashi*, Takao Watanabe* and Kunitoshi Mitsumori
"... the results of the present study provide evidence that FL was not
only a hepatic tumor promoter but also a hepatic tumor initiator."
Trovafloxacin, a
quinolone antibiotic, is an idiosyncratic hepatotoxin. Further
analysis revealed unique regulation of 142 genes, including some
involved in RNA transcription.
Levofloxacin-induced acute fulminant hepatic
failure in a patient with chronic hepatitis B infection.
Adverse events associated with pyrazinamide and levofloxacin in the
treatment of latent multidrug-resistant tuberculosis
Incidence of Serious Side Effects from First-Line Antituberculosis
Drugs among Patients Treated for Active Tuberculosis
"...In
more recent studies, the incidence of drug-induced hepatitis was 18% in patients taking levofloxacin (Levoquin) and PZA for 6
months..."}
Non-Fatal Acute Liver Injury Possibly Related to High-Dose
Ciprofloxacin
M. Goetz, P. R. Galle, A. Schwarting
A1 Medical Clinic I, University of Mainz, Langenbeckstrasse 1, 55131,
Mainz, Germany
Acute hepatitis associated with oral levofloxacin therapy in a
hemodialysis patient.
CMAJ 2003 Apr 1;168(7):847-8 (ISSN: 0820-3946)
Schwalm JD; Lee CH Department of Pathology and Molecular
Medicine, McMaster University, Hamilton, ON.
Acute hepatitis associated with levaquin in a
patient with renal insufficiency taking amiodarone June 25, 2003
Acute hepatitis associated with oral
levofloxacin therapy in a hemodialysis patient.
Possible ciprofloxacin-induced acute cholestatic
jaundice
Ciprofloxacin-induced acute liver
injury: case report and review of literature
Gatifloxacin-Associated Acute
Hepatitis
Suspected ciprofloxacin-induced
hepatotoxicity
Hepatitis Associated with
Amoxicillin/Clavulanic Acid and/or Ciprofloxacin.
Ciprofloxacin-induced glutathione redox status
alterations in rat tissues.
Effects of ciprofloxacin on fetal hepatocytes.
Possible Levofloxacin-Induced Acute
Hepatocellular Injury in a Patient with Chronic Obstructive Lung
Disease
Anita Karim,1 Shahid Ahmed,1 Leonard J. Rossoff,1 Rina K. Siddiqui,2
and Harry N. Steinberg1
Possible
gatifloxacin-induced fulminant hepatic failure.
Coleman CI, Spencer JV, Chung JO, Reddy P.
Infection with Basidiobolus ranarum in two dogs
{treated with enrofloxacin resulting in possible liver damage.}
Greene CE, Brockus CW,
Currin MP, Jones CJ. Department of Small Animal Medicine,
College of Veterinary Medicine, University of Georgia, Athens 30602,
USA.
Acute liver failure due to trovafloxacin: CT findings
H. K. Pannu A1, L. Gottlieb A2, E. K. Fishman A1
Antimicrobial-Associated Acute Hepatitis {associated with
Levofloxacin, Gatifloxacin}
Susan C. Nicholson, M.D., C. Douglas Webb,
Ph.D., and Robert C. Moellering, Jr., M.D.
Quinolones may induce hepatitis
BMJ 1997;314:869 (22 March) Drug points
Ciprofloxacin-induced acute liver injury: case report and review of
literature Annette Zimpfer1, Albert Propst2, Gregor
Mikuz3, Wolfgang Vogel2, Luigi Terracciano1 and Sylvia Stadlmann3 (1)
Institute of Pathology, University of Basel, Schoenbeinstrasse 40,
4003 Basel, Switzerland (2) Department of Gastroenterology and
Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020
Innsbruck, Austria (3) Institute of Pathology, University of
Innsbruck, Muellerstrasse 44, 6020 Innsbruck, Austria
Effects of ciprofloxacin on foetal hepatocytes.
J Pak Med Assoc. 2003 Oct;53(10):448-50. Channa MA, Janjua MZ.
Department of Anatomy, Basic Medical Sciences Institute, Jinnah
Postgraduate Medical Centre, Karachi.
Fulminant hepatic failure possibly related to ciprofloxacin
BK Grassmick, VT Lehr, and AS Sundareson
Antibiotic-associated hepatitis: update from 1990
T Vial, M Biour, J Descotes, and C Trepo
"The most important recent information is the possibility of
protracted liver cholestasis with bile duct injuries induced by
several antibiotics, particularly penicillinase-resistant penicillins,
and the identification of new potentially hepatotoxic antibiotics,
namely, roxithromycin, ciprofloxacin,
and trimethoprim. "
Acute liver failure: Clinical features,
outcome analysis, and applicability of prognostic criteria
A. Obaid Shakil 1 *, David Kramer 2, George V. Mazariegos 3, John J.
Fung 3, Jorge Rakela
"Demographic and Etiologic Features of Patients With Acute Liver
Failure ... Ampicillin clavulanate, 1 patient; antabuse, 2
patients; ciprofloxacin, 1 patient ... "
Delayed and prolonged cholestatic hepatitis with ductopenia after
long-term ciprofloxacin therapy for Crohn's disease.
Hepatol. 2002 Nov;37(5):696-9. Bataille L, Rahier J, Geubel A.
Department of Gastroenterology and Pathology, Saint Luc University
Hospital, Universite Catholique de Louvain, 10 Avenue Hippocrate, 1200
Brussels, Belgium.
Fatal subfulminant hepatic failure with ofloxacin
Am J Gastroenterol. 2000 Jun;95(6):1606. .Gonzalez Carro P, Huidobro
ML, Zabala AP, Vicente EM. Trovafloxacin-associated leukopenia.
Ann Pharmacother. 2001 Jan;35(1):41-4. Mitropoulos FA, Angood PB,
Rabinovici R. Yale New Haven Hospital, New Haven, CT, USA.
Trovafloxacin-Induced Acute Hepatitis
M. Isabel Lucena,1 Raúl J. Andrade,2 Luis Rodrigo,3 Javier Salmerón,4
Arancha Alvarez,3 M. J. Lopez-Garrido,4 Raquel Camargo,2 and Ramiro
Alcantára2
Adverse events associated with pyrazinamide and levofloxacin in the
treatment of latent multidrug-resistant tuberculosis
Tina Papastavros, Lisa R. Dolovich, Anne Holbrook, Lori Whitehead, and
Mark Loeb
The following references have no
abstract or full text available to the general public. Some of
these articles however are available for a fee on several Internet
Sites such as Springer, Blackwell Synergy, etc, or from the
publication cited:
Norfloxacin-Induced Cholestatic Jaundice
(full text can be purchased from Blackwell Synergy by following this
link)
American Journal of Gastroenterology
Volume 93 Issue 11 Page 2309 - November 1998
doi:10.1111/j.1572-0241.1998.02309.x
M. Isabel Lucena, Ph.D.a*Raul J. Andrade, Ph.D.bHerminia
Sanchez-Martinez, M.D.cJose Manuel Perez-Serrano, M.D.cAntonio Gomez-Outes,
M.D.daClinical Pharmacology Service Department of Gastroenterology
University Hospital, School of Medicine University of Malaga Málaga,
Spain Liver Unit Department of Gastroenterology University Hospital,
School of Medicine University of Malaga Málaga, Spain Department of
Internal Medicine Hospital La Inmaculada Huercal-Overa, Almeria,
SpaindClinical Pharmacology Service Department of Gastroenterology
University Hospital, School of Medicine University of Malaga Málaga,
Spain
Norfloxacin-induced eosinophilic necrotizing granulomatous
hepatitis
(full text can be purchased from Blackwell Synergy by following this
link)
American Journal of Gastroenterology
Volume 95 Issue 12 Page 3662 - December 2000
doi:10.1111/j.1572-0241.2000.03404.x
Einar BjornssonBjörnssona, Rolf Olssonab, Helen RemottibaDepartment of
Internal Medicine, Sahlgrenska University Hospital, Göteborg,
SwedenbDepartment of Pathology, New York Presbyterian Hospital, Weill
Cornell Medical Center, New York, New York, USA
Norfloxacin-Induced Acute Cholestatic Hepatitis in a Patient With
Alcoholic Liver Cirrhosis
(full text can be purchased from Blackwell Synergy by following this
link)
American Journal of Gastroenterology
Volume 94 Issue 8 Page 2324 - August 1999
doi:10.1111/j.1572-0241.1999.02324.x
Manuel Romero-Gómez, M.D.a
Emilio Suarez Garcia, M.D.a
M. Castro Fernández, M.D.aaDigestive Unit
Hospital Universitario de Valme
Sevilla, Spain
Antibiotic-associated hepatitis: update from 1990
T Vial, M Biour, J Descotes, and C Trepo
Am J Gastroenterol. 2002 Jul;97(7):1853-4. Related Articles, Links
Moxifloxacin-induced acute liver injury.
Soto S, Lopez-Roses L, Avila S, Lancho A, Gonzalez A, Santos E, Urraca
B.
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1572-0241.2002.05873.x?cookieSet=1
A 32-Year-Old Man with Hepatitis C Who
Developed Progressive Liver Failure after a Bone Marrow Transplant
DIAGNOSTIC PROBLEMS IN HEPATOLOGY Semin Liver Dis 2002;
22: 103-108 DOI: 10.1055/s-2002-23211 Andre C. Lyra1
M.D. , Elizabeth M. Brunt2 M.D. , Steven Pincus3 M.D. Ph.D. , Adrian
M. Di Bisceglie1 M.D. FACP 1: Division of Gastroenterology and
Hepatology, Department of Internal Medicine, Saint Louis University
School of Medicine, St. Louis, Missouri 2: Department of
Pathology, Saint Louis University School of Medicine, St. Louis,
Missouri 3: Division of Hematology and Oncology, Department of
Internal Medicine, Saint Louis University School of Medicine, St.
Louis, Missouri
Acute fatal hepatitis related to levofloxacin
J Hepatol. 2001 Aug;35(2):308-9..Spahr L, Rubbia-Brandt L, Marinescu
O, Armenian B, Hadengue A
Fatal subfulminant hepatic failure with
ofloxacin
American Journal of Gastroenterology Volume 95 Issue 6 Page 1606 -
June 2000 doi:10.1111/j.1572-0241.2000.02118.x P. González Carro,
M.D.a, M. L. Legaz Huidobro, M.D.a, A. Pinardo Zabala, M.D.a, and E.
Muńoz Vicente, M.D.baDigestive Unit, Hospital General "Mancha-Centro"
Alc´zar de San Juan, Ciudad Real, SpainbPathology, Hospital General "Mancha-Centro"
Alc´zar de San Juan, Ciudad Real, Spain
Norfloxacin-induced eosinophilic necrotizing
granulomatous hepatitis
American Journal of Gastroenterology
Volume 95 Issue 12 Page 3662 - December 2000
doi:10.1111/j.1572-0241.2000.03404.x Einar BjornssonBjörnssona,
Rolf Olssonab,
Helen RemottibaDepartment
of Internal Medicine, Sahlgrenska University Hospital, Göteborg,
SwedenbDepartment of Pathology, New York Presbyterian
Hospital, Weill Cornell Medical Center, New York, New York, USA
Liver disfunction due to ciprofloxacin.
Acta Gastroenterol Belg. 1995 Sep-Dec;58(5-6):475-6. Alcalde M, Donoso
MS, Carcfa-Diaz M, Pascasio JM, Narvaez I.
Norfloxacin-Induced Cholestatic Jaundice
American Journal of Gastroenterology Volume 93 Issue 11 Page 2309 -
November 1998 doi:10.1111/j.1572-0241.1998.02309.x M.
Isabel Lucena, Ph.D.a*Raul J. Andrade, Ph.D.bHerminia
Sanchez-Martinez, M.D.cJose Manuel Perez-Serrano, M.D.cAntonio Gomez-Outes,
M.D.daClinical Pharmacology Service Department of Gastroenterology
University Hospital, School of Medicine University of Malaga Málaga,
SpainbLiver Unit Department of Gastroenterology University Hospital,
School of Medicine University of Malaga Málaga, SpaincDepartment of
Internal Medicine Hospital La Inmaculada Huercal-Overa, Almeria,
SpaindClinical Pharmacology Service Department of Gastroenterology
University Hospital, School of Medicine University of Malaga Málaga,
Spain
Ciprofloxacin induced bradycardia:
A case report
LETTER Year : 1994 | Volume : 26 | Issue : 2 | Page : 164 Dhobi GN,
Shafiqa TA Correspondence Address: Dhobi G N
Jarisch-Herxheimer reaction associated with ciprofloxacin
administration for tick-borne relapsing fever.
"Liver function tests revealed a total bilirubin of
1.3 mg/dl, an aspartate ... She was
prescribed a 3-day course of oral ciprofloxacin (500 mg twice a day)
and ... " Pediatric Infectious Disease Journal. 21(6):571-573, June
2002.
Webster, Gregory B.A.; Schiffman, Joshua D. M.D.; Dosanjh, Amarjit S.
B.S.; Amieva, Manuel R. M.D., Ph.D.; Gans, Hayley A. M.D.; Sectish,
Theodore C. M.D.
Is Ciprofloxacin a New Cause of Acute
Pancreatitis? "... difficile enterocolitis, and abnormalities of liver
biochemistry. As far as we know, acute pancreatitis has not been
described after taking ciprofloxacin. ... "
Journal of Clinical Gastroenterology. 31(4):336, December 2000.
Mann, Steven M.R.C.P.; Thillainayagam, Andrew M.D., M.R.C.P.
CIPROFLOXACIN-INDUCED ACUTE RENAL FAILURE IN A PATIENT WITH CYSTIC
FIBROSIS.
Pediatric Infectious Disease Journal. 20(3):320-321, March 2001.
Bald, Martin M.D.; Ratjen, Felix M.D.; Nikolaizik, Winfried M.D.;
Wingen, Ann-Margret M.D.
Norfloxacin-induced eosinophilic necrotizing granulomatous
hepatitis
American Journal of Gastroenterology
Volume 95 Issue 12 Page 3662 - December 2000
doi:10.1111/j.1572-0241.2000.03404.x Einar BjornssonBjörnssona,
Rolf Olssonab,
Helen RemottibaDepartment
of Internal Medicine, Sahlgrenska University Hospital, Göteborg,
SwedenbDepartment of Pathology, New York Presbyterian
Hospital, Weill Cornell Medical Center, New York, New York, USA
Fatal hepatic failure associated with ciprofloxacin.
Lancet. 1994 Mar 19;343(8899):738-9. Comment in: Lancet. 1994 May
7;343(8906):1163. (Lancet. 1994 May 7;343(8906):1163. Who is
withholding information?) Pfeiffer M, Reiter C. Fuchs S, Simon
Z, Brezis M.
Norfloxacin induced hepatitis.
Davoren P, Mainstone K. Med J Aust 1993;159:423.
Ofloxacin induced acute severe hepatitis.
Blum A. South Med J 1991;84:1158.
Acute Eosinophilic Hepatitis from Trovafloxacin
H. J.L. Chen, K. J. Bloch, and J. A. Maclean N. Engl. J. Med.,
February 3, 2000; 342(5): 359 - 360. Date: April 2001 Pages: 925
- 926 CASE REPORT: Trovafloxacin Hepatotoxicity Dariusz A. Lazarczyk,
Neal S. Goldstein and Stuart C. Gordon
Case Report: Cholestatic Jaundice Induced by Ciprofloxacin
Publisher: Springer Science+Business Media B.V., Formerly Kluwer
Academic Publishers B.V. ISSN: 0163-2116 (Paper) 1573-2568 (Online)
DOI: 10.1023/A:1018870029216 Issue: Volume 42, Number 1 Date:
January 1997 Pages: 192 - 194 Jodie K. Labowitz and
William B. Silverman
Fulminant toxic epidermal necrolysis induced by trovafloxacin.
Matthews MR, Caruso DM, Phillips BJ, Csontos LG.
Arch Intern Med. 1999 Oct 11;159(18):2225. Related Articles, Links
http://archinte.ama-assn.org/cgi/content/full/159/18/2225
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1
Schwalm JD, Lee CH.Acute hepatitis associated with oral levofloxacin
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CMAJ. 2003 Apr 1;168(7):847-8.
PMID: 12668542 [PubMed - indexed for MEDLINE]
2
Artymowicz RJ.Comment: possible gatifloxacin-induced fulminant
hepatic failure.
Ann Pharmacother. 2002 Nov;36(11):1810; author reply 1810. No
abstract available.
PMID: 12398583 [PubMed - indexed for MEDLINE]
3
Soto S, Lopez-Roses L, Avila S, Lancho A, Gonzalez A, Santos E, Urraca B.Moxifloxacin-induced
acute liver injury.
Am J Gastroenterol. 2002 Jul;97(7):1853-4. No abstract
available.
PMID: 12135060 [PubMed - indexed for MEDLINE]
4
Coleman CI, Spencer JV, Chung JO, Reddy P.Possible
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Pharmacotherapy. 2002 Jun;22(6):794-6; discussion 796-7.
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Henann NE, Zambie MF.Gatifloxacin-associated acute hepatitis.
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7
Meadows M.Serious liver injury. Leading reason for drug removals,
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FDA Consum. 2001 May-Jun;35(3):8-9. No abstract available.
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Lazarczyk DA, Goldstein NS, Gordon SC.Trovafloxacin hepatotoxicity.
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Chen HJ, Bloch KJ, Maclean JA.Acute eosinophilic hepatitis from
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Lucena MI, Andrade RJ, Rodrigo L, Salmeron J, Alvarez A, Lopez-Garrido MJ,
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Clin Infect Dis. 2000 Feb;30(2):400-1. No abstract available.
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Hautekeete ML.Hepatotoxicity of antibiotics.
Acta Gastroenterol Belg. 1995 May-Aug;58(3-4):290-6. Review.
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Sherman O, Beizer JL.Possible ciprofloxacin-induced acute cholestatic
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Ann Pharmacother. 1994 Oct;28(10):1162-4.
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Blum MD, Graham DJ, McCloskey CA.Temafloxacin syndrome: review of 95
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Clin Infect Dis. 1994 Jun;18(6):946-50. Review.
PMID: 8086558 [PubMed - indexed for MEDLINE]
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fluoroquinolones in hepatic failure.
J Antimicrob Chemother. 1990 Oct;26 Suppl B:61-7. Review.
PMID: 2258353 [PubMed - indexed for MEDLINE]
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Cheung O, Chopra K, Yu T, Nalesnik MA, Amin S, Shakil AO.Gatifloxacin-induced
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Ann Intern Med. 2004 Jan 6;140(1):73-4. No abstract available.
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Jones SF, Smith RH.Quinolones may induce hepatitis.
BMJ. 1997 Mar 22;314(7084):869. No abstract available.
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