Emergency Radiology
Publisher: Springer-Verlag GmbH
ISSN: 1070-3004 (Paper) 1438-1435 (Online)
Issue: Volume 8, Number 2

Date: April 2001
Pages: 108 - 110
Acute liver failure due to trovafloxacin: CT findings

H. K. Pannu A1, L. Gottlieb A2, E. K. Fishman A1

A1 Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA Tel.: + 1-4 10-9 55 65 00 Fax: + 1-4 10-6 14 38 96
A2 Department of Surgery, Greater Baltimore Medical Center, Baltimore, MD 21287, USA

Abstract:

Abstract Symptomatic drug-induced hepatic adverse events due to trovafloxacin, a new fluoroquinolone antibiotic, are uncommon, but recent severe reactions have led to restriction on its use. We report the clinical course and computed tomography findings in a patient who developed acute liver failure shortly after commencing treatment with trovafloxacin. Extensive hepatic necrosis occurred and the patient ultimately died of her liver disease.