The Fluoroquinolone Toxicity Research Foundation

 
  You are visitor number Counter
Pediatric Research                     See downloads for: Adobe Files



ACHILLES TENDONITIS: Both the older and newer fluoroquinolones have been associated with arthropathy in weight bearing joints. Studies have shown erosion and permanent lesions of the cartilage due to quinolone use in animals. Although Achilles tendon rupture has been the most common injury with over 200 cases reported other joints may also be affected. Injury has been noted up to 90 days out after completion of therapy. Due to the affect on cartilage, fluoroquinolones are contraindicated in pregnant or nursing mothers and children under the age of 18.(15)
source: http://pharmacy.orst.edu/drug_policy/reviews-evaluations/fluroquinolone-lit.html

All of the fluoroquinolones have been shown to cause cartilage damage in immature animals; NONE is FDA-approved for use in children less than 18 years of age or in pregnant or nursing women.
source:http://consult.hsc.wvu.edu/newdrugs/tequin.html

In addition, as a class, FQs are NOT currently approved for pediatric applications because of drug-associated articular cartilage damage noted in animal studies.
source:http://www.uspharmacist.com/NewLook/CE/revofnewdrugs/lesson.cfm