Levaquin
  Levofloxacin
  Ortho McNeil  Johnson and Johnson
  NDA  020634, 020635, 021721
  Latest Package Insert
  Levaquin 2002,  2005  2007 2008
  Safety Profile
  More serious and fatal adverse reactions reported than any
  other drug in this class  DO NOT USE 

Listed as a DO NOT USE drug
Numerous other, safer antibiotics are approved to treat the same infections as this drug

There are numerous FATAL adverse reactions associated with this drug. (Read More)

BLACK BOX WARNINGS TO BE ADDED (Read More)
 FDA is notifying the makers of fluoroquinolone antimicrobial
 drugs for systemic use of the need to add a boxed warning to
 the prescribing information about the increased risk of developing
 tendinitis and tendon rupture in patients taking fluoroquinolones
 and to develop a Medication Guide for patients.

Torn Knee Cartilage requiring surgical repair in a Pediatric Patient, secondary to levaquin.

We report upon a 14 year old male who suffered ruptured cartilage in both knees secondary to levaquin.
Click Here to Read More

Liver damage linked to levofloxacin

The latest package insert for Levaquin (May 2008) now includes
NUMEROUS updated warnings concerning fatal liver
damage following levaquin therapy.
Click here to read more...

Click here to read the Label Changes effective June 2007

Click here to read the Label Changes effective May 15, 2007

Changes to the monograph (2001)  LEVAQUIN (levofloxacin) Tablets & Injection [December 18, 2001: ORTHO-McNEIL]

WARNINGS

Some quinolones, including levofloxacin, have been associated with prolongation of the QT interval on the electrocardiogram and infrequent cases of arrhythmia. During post-marketing surveillance, rare cases of torsades de pointes have been reported in patients taking levofloxacin. These reports generally involved patients who had other with concurrent medical conditions and the relationship to levofloxacin has not been established. Among drugs known to cause prolongation of the QT interval, the or concomitant medications that may have been contributory. The risk of arrhythmias may be reduced by avoiding use in the presence of concurrent use with other drugs that prolong the QT interval including hypokalemia, significant bradycardia, or concurrent treatment with class Ia or class III antiarrhythmic agents; in addition, use of levofloxacin in the presence of risk factors for torsades de pointes such as hypokalemia, significant bradycardia, and cardiomyopathy should be avoided.

Other adverse reactions associated with the fluoroquinolones

Peripheral Neuropathy
Cases of sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias and weakness have been reported in patients receiving quinolones.

QUINOLONES MAY HAVE THE POTENTIAL TO PROLONG THE QTc INTERVAL OF THE ELECTROCARDIOGRAM IN SOME PATIENTS. DUE TO THE LACK OF CLINICAL EXPERIENCE, QUINOLONES SHOULD BE AVOIDED IN PATIENTS WITH KNOWN PROLONGATION OF THE QTc INTERVAL, PATIENTS WITH UNCORRECTED HYPOKALEMIA, AND PATIENTS RECEIVING CLASS IA (E.G. QUINIDINE, PROCAINAMIDE) OR CLASS III (E.G. AMIODARONE, SOTALOL) ANTIARRHYTHMIC AGENTS.

Ruptures of the shoulder, hand, and Achilles tendons that required surgical repair or resulted in prolonged disability have been reported in patients receiving quinolones. Tendon rupture can occur during or after therapy with quinolones.

Quinolones may cause central nervous system (CNS) events including nervousness, agitation, insomnia, anxiety, nightmares, or paranoia.

As with other quinolones, disturbances of blood glucose, including symptomatic hyper- and hypoglycemia, have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic (e. g., glyburide) or with insulin. In these patients, the monitoring of blood glucose is recommended.

In 2004 new warning labels added to all of the Fluoroquinolones regarding Peripheral Neuropathy (irreversible nerve damage), Tendon Damage, Heart Problems (prolonged QT Interval / Torsades de pointes), Pseudomembranous colitis, Rhabdomyolysis (muscle wasting), Steven Johnson Syndrome, as well as concurrent usage of NSAIDs contributing to the severity of these reactions.
.
Although such events have been reported since the mid sixties, the FDA waited almost forty years to add such warnings to the package inserts.  These new warnings again fail to adequately warn either the patient or the physician.

"Drug companies write the package inserts of all drugs, carefully including the information they choose and
omitting information they want to avoid. Drug companies underwrite a large percentage of continuing
education courses for doctors. In doing so, they make sure that the speakers represent the company view.
Drug companies design studies that are meant to produce favorable results and then publish the studies in
medical journals. Studies with unfavorable results are not published. Drug reps typically bring stacks of
studies, all favorable, which impress doctors, who no longer have the time or motivation to search  the
medical literature themselves. Drug reps do not include independent studies with less favorable
conclusions. Many doctors never see these." 

Source:   THE MEDICAL PROFESSION AND THE CULTURE OF CORRUPTION

PERIPHERAL NEUROPATHY (as noted above)
Achilles and other tendon ruptures that required surgical repair or resulted in prolonged disability.
Convulsions, increased intracranial pressure, and toxic psychosis.
Central nervous system (CNS) events including: dizziness, confusion, tremors, hallucinations, depression, and, ly, suicidal thoughts or acts. These reactions may occur following the first dose.
Severe hypersensitivity reactions characterized by rash, fever, eosinophilia, jaundice, and hepatic necrosis with fatal outcome
Pseudomembranous colitis and may range in severity from mild to life-threatening.
Lameness in immature dogs with permanent lesions of the cartilage.
Central nervous system (CNS) events, including nervousness, agitation, insomnia, anxiety, nightmares or paranoia.
Crystalluria
Moderate to severe photoxicity

Additional adverse events reported:

Body as a Whole: Change in serum phenytoin.

Cardiovascular: Palpitation, atrial flutter, ventricular ectopy, syncope, hypertension, angina pectoris, myocardial infarction, cardiopulmonary arrest, cerebral thromobosis. Cardiovascular collapse, cardiopulmonary arrest, myocardial infarction, arrhythmia, tachycardia, palpitation, cerebral thrombosis, syncope, cardiac murmur, hypertension, hypotension, angina pectoris. Postural hypotension, vasculitis.

Central Nervous System: Dizziness, lightheadedness, insomnia, nightmares, hallucinations, manic reaction, irritability, tremor, ataxia, convulsive seizures, lethargy, drowsiness, weakness, malaise, anorexia, phobia, depersonalization, depression, paresthesia. Convulsive seizures, paranoia, toxic psychosis, depression, dysphasia, phobia, depersonalization, manic reaction, unresponsiveness, ataxia, confusion, hallucinations, dizziness, lightheadedness, paresthesia, anxiety, tremor, insomnia, nightmares, weakness, drowsiness, irritability, malaise, lethargy Agitation, confusion, delirium, dysphasia, myoclonus, nystagmus, toxic psychosis.
.
Gastrointestinal: Painful oral mucosa, oral candidiasis, dysphagia, intestinal perforation, gastrointestinal bleeding. Cholestatic jaundice has been reported. Ileus, jaundice, gastrointestinal bleeding, C. difficle associated diarrhea, pseudomembranous colitis, pancreatitis, hepatic necrosis, intestinal perforation, dyspepsia, epigastric or abdominal pain, vomiting, constipation, oral ulceration, oral candidiasis, mouth dryness, anorexia, dysphagia, flatulence Constipation, dyspepsia, flatulence, hepatic necrosis, jaundice, pancreatitis, pseudomembranous colitis. (The onset of pseudomembranous colitis symptoms may occur during or after antimicrobial treatment.)

Hemic/Lymphatic: Agranulocytosis, hemolytic anemia, methemaglobinemia, prolongation of prothrombin time

Metabolic/Nutritional: Elevation of serum triglycerides, cholesterol, blood glucose, serum potassium.

Musculoskeletal: Arthralgia or back pain, joint stiffness, achiness, neck or chest pain, flare up of gout. Arthralgia, jaw, arm or back pain, joint stiffness, neck and chest pain, achiness, flare up of gout Myalgia, possible exacerbation of myasthenia gravis, tendinitis/tendon rupture.

Renal/Urogenital: Interstitial nephritis, nephritis, renal failure, polyuria, urinary retention, urethral bleeding, vaginitis, acidosis. Renal failure, intarstitial nephritis, hemorrhagic cystitis, renal calcuti, frequent urination, acidosis, urethral bleeding, polyuria, urinary retention, gynecomastia, candiduria, vaginitis. Crystalluria, cylindruria, hematuria, and albuminutia have also been reported.
Albuminuria, candiduria, renal calculi, vaginal candidiasis.

Respiratory: Dyspnea, epistaxis, laryngeal or pulmonary edema, hiccough, hemophysis, bronchospasm, pulmonary embolism. Respiratory arrest, pulmonary embolism, dyspnea, pulmonary edema, respiratory distress, pleural effusion, hemoptysis, epistaxis, hiccough

Skin/Hypersensitivity: Pruritus, urticaria, photosensitivity, flushing, fever, chills, angioedema, edema of the face, neck, lips, conjunctivae or hands, cutaneous candidiasis, hyperpigmentation, erytherna nodosum. Allergic reactions ranging from urticaria to anaphylactic reactions have been reported. Anaphylactic reactions, erythema multiforme/Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, vasculitis, angioedema, edema of the lips, face, neck, conjunctivae, hands or lower extremities, purpura, fever, chills, flushing, pruritus, urtigaria, cutaneous candidiasis, vesicles, increased perspiration, hyperpigmentation, erythema nodosum, photosensitivity. Allergic reactions ranging from urticaria to anaphylactic reactions have been reported. Anaphylactic reactions, erythema multiforme/Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis.

Special Senses: Blurred vision, disturbed vision (change in color perception, overbrightness of lights), decreased visual acuity, diplopia, eye pain, tinnitus, hearing loss, bad taste. Decreased visual acuity, blurred vision, disturbed vision (flashing lights, change in color perception, overbrightness of lights, diplopia), eye pain, anosmia, hearing loss, tinnitus, nystagmus, a bad taste. Also reported were agranulocytosis, prolongation of prothrombin time, and possible exacerbation of myasthenia gravis. anosmia, taste loss.
 

Adverse Laboratory Changes

Oral

Changes in Laboratory Parameters Listed as Adverse Events:

Other changes occurring ly during administration of fluoroquinolone were: elevation of serum amylase, decrease of blood glucose, pancytopenia, leukocytosis, elevated sedimentation rate, change in serum phenytoin, decreased prothrombin time, hemolytic anemia, and bleeding diathesis.
 

ANIMAL PHARMACOLOGY
Oral and I.V.

Reported Adverse Reactions to Levaquin (AKA Tavanic) from Dec 28, 2005 - September 20, 2006

http://www.patientsville.com/medication/tavanic_side_effects.htm

Health Professional from JAPAN reported TAVANIC problem on Dec 28, 2005. Male patient, 48 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: renal infarct. TAVANIC dosage: unknown. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Dec 26, 2005. Male patient, 46 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: eosinophilia, injection site nodule, pruritus. TAVANIC dosage: unknown. During the same period patient was treated with LOVENOX, PYOSTACINE, FRAXODI, LEXOMIL, NEURONTIN, MOPRAL, RIVOTRIL. Patient was hospitalized. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on Jan 05, 2006. Male patient, 59 years of age, was diagnosed with urinary tract infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: polymyositis. TAVANIC dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on Jan 05, 2006. Female patient, 66 years of age, was diagnosed with tooth infection, breast cancer and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: tendonitis. TAVANIC dosage: unknown. During the same period patient was treated with TAXOL, DEXAMETHASONE. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Jan 05, 2006. Male patient, 55 years of age, was diagnosed with pain, anxiety, depression, prophylaxis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cytolytic hepatitis, hepatosplenic candidiasis, renal failure. TAVANIC dosage: unknown. During the same period patient was treated with TOPALGIC, POSACONAZOLE, LAROXYL, FORTUM, NEURONTIN, XANAX, EFFEXOR, NEXIUM. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Jan 06, 2006. Male patient, 66 years of age, was diagnosed with candidiasis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cerebral haemorrhage, epistaxis, haematemesis, haemoptysis, purpura, thrombocytopenia. TAVANIC dosage: unknown. During the same period patient was treated with ZINNAT, TRIFLUCAN. Patient was hospitalized. Patient died on 11/03/2005.

Health Professional from JAPAN reported TAVANIC problem on Jan 06, 2006.



*Physician from JAPAN reported TAVANIC problem on Jan 16, 2006. Female patient, 70 years of age, was diagnosed with bronchitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: muscle rupture, tendon disorder. TAVANIC dosage: unknown. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Jan 19, 2006. Male patient, 48 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: urethral cancer. TAVANIC dosage: unknown. Patient recovered.



Health Professional from JAPAN reported TAVANIC problem on Jan 26, 2006. Female patient, 76 years of age, was diagnosed with bronchopneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: prothrombin time prolonged. TAVANIC dosage: unknown. During the same period patient was treated with MARCUMAR, COVERSUM, SORTIS, NITRATPFLASTER, AQUAPHOR. Patient was hospitalized. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on Jan 30, 2006. Male patient, 74 years of age, was diagnosed with bronchitis, hypertension, coronary artery disease and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: muscle rupture, tendon disorder, tendonitis. TAVANIC dosage: unknown. During the same period patient was treated with PROVASIN, SIMVAHEXAL, ARELIX, ASPIRIN. Patient recovered.

Consumer or non-health professional from reported TAVANIC problem on Jan 26, 2006. Female patient, 80 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: hypoglycaemic coma. TAVANIC dosage: unknown. During the same period patient was treated with AMARYL, GLUCOPHAGE, ASPIRIN, DISTRANEURIN, TOREM, DIGOXIN, TOLVON. Patient was hospitalized. Patient recovered.

TAVANIC problem was reported by a Consumer or non-health professional from on Jan 26, 2006. Female patient, 80 years of age, was diagnosed with pneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: coma, hypoglycaemic coma, mydriasis, pupils unequal, renal failure, sopor, unresponsive to verbal stimuli. TAVANIC dosage: unknown. During the same period patient was treated with AMARYL, GLUCOPHAGE, ASPIRIN, DISTRANEURIN, TOREM, DIGOXIN, TOLVON. Patient was hospitalized. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on Feb 08, 2006. Female patient, 48 years of age, was diagnosed with eye infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: convulsion, loss of consciousness. TAVANIC dosage: unknown. During the same period patient was treated with TOBRAMYCIN. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on Feb 09, 2006. Male patient, 45 years of age, was diagnosed with prostatitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: ligament injury. TAVANIC dosage: unknown. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Feb 10, 2006. Male patient, 46 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: eosinophilia, pruritus. TAVANIC dosage: unknown. During the same period patient was treated with LOVENOX, PYOSTACINE, FRAXODI, LEXOMIL, NEURONTIN, OMEPRAZOLE, CLONAZEPAM. Patient was hospitalized. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Feb 15, 2006. Female patient, 84 years of age, was diagnosed with urinary tract infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: vertigo. TAVANIC dosage: unknown. During the same period patient was treated with ISOPTIN, TIMOPTIC, MEDROL, METHOTREXATE, TAVOR, AIRTAL. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on Feb 16, 2006. Male patient was diagnosed with lower respiratory tract infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: tendon rupture. TAVANIC dosage: unknown. Patient died.

*TAVANIC problem was reported by a Health Professional from JAPAN on Feb 22, 2006. Female patient, 38 years of age, was diagnosed with bronchitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous, drug exposure during pregnancy, haemorrhage. TAVANIC dosage: unknown. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Feb 23, 2006. Female patient, 85 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, multi-organ failure, torsade de pointes, ventricular fibrillation, ventricular tachycardia. TAVANIC dosage: unknown. During the same period patient was treated with FLECAINIDE ACETATE, DIGITALIS. Patient died on 01/01/2005.

*TAVANIC problem was reported by a Health Professional from JAPAN on Feb 24, 2006. Male patient, 62 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: amnesia, muscle atrophy, myalgia. TAVANIC dosage: unknown. During the same period patient was treated with ROVAMYCINE, PANTESTONE, PEVARYL, MYCOLOG, CYTEAL. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on Feb 27, 2006. Male patient was diagnosed with lower respiratory tract infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: tendon rupture. TAVANIC dosage: unknown. Patient died.

*TAVANIC problem was reported by a Health Professional from JAPAN on Mar 03, 2006. Male patient, 79 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: pneumonia, rhabdomyolysis. TAVANIC dosage: unknown. During the same period patient was treated with NEXIUM, TRANSTEC, ASPIRIN, FUROSEMIDE, MOVICOL. Patient was hospitalized. Patient died on 01/19/2006.

*Health Professional from JAPAN reported TAVANIC problem on Mar 06, 2006. Female patient, 59 years of age, was diagnosed with urinary tract infection, pancytopenia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, febrile neutropenia, multi-organ failure, sepsis, toxic epidermal necrolysis. TAVANIC dosage: unknown. During the same period patient was treated with VANCOMYCIN, PARACETAMOL, OMEPRAZOLE, NEUPOGEN. Patient died on 01/09/2006.



*Health Professional from JAPAN reported TAVANIC problem on Apr 04, 2006. Male patient, 62 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: amnesia, muscle atrophy, myalgia, tendonitis. TAVANIC dosage: unknown. During the same period patient was treated with ROVAMYCINE, PANTESTONE, PEVARYL, MYCOLOG, CYTEAL. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Apr 06, 2006. Male patient, 51 years of age, was diagnosed with pyelonephritis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: extraocular muscle disorder, eye pain, periorbital oedema. TAVANIC dosage: unknown. Patient recovered.

Consumer or non-health professional from reported TAVANIC problem on Apr 10, 2006. Female patient, 90 years of age, was diagnosed with respiratory disorder, enterocolitis infectious, enteritis, gastroenteritis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: muscle contractions involuntary. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL. Patient was hospitalized. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on Apr 12, 2006. Female patient, 84 years of age, was diagnosed with bronchitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: ischaemic stroke, tendon rupture. TAVANIC dosage: unknown. During the same period patient was treated with OROKEN. Patient died on 12/25/2005.



TAVANIC problem was reported by a Consumer or non-health professional from on Apr 24, 2006. Male patient, 59 years of age, was diagnosed with pneumonia, bipolar i disorder and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cholestasis, gamma-glutamyltransferase increased, hepatic enzyme increased. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL, DEPAMIDE, ACETAMINOPHEN, TRIZIVIR, MEPRONIZINE, EFFEXOR, STILNOX, EQUANIL. Patient was hospitalized. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on Apr 18, 2006. Female patient, 51 years of age, was diagnosed with sinusitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: polyneuropathy. TAVANIC dosage: unknown. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Apr 25, 2006. Female patient, 68 years of age, was diagnosed with deep vein thrombosis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: convulsion, electrolyte imbalance, irritability. TAVANIC dosage: unknown. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Apr 26, 2006. Female patient was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous, drug exposure during pregnancy. TAVANIC dosage: unknown. Patient recovered.

TAVANIC problem was reported by a Health Professional from FRANCE on Apr 28, 2006. Female patient, 76 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: drug interaction, international normalised ratio increased, rectal haemorrhage. TAVANIC dosage: unknown. During the same period patient was treated with SINTROM, PROZAC, SECTRAL, GLUCOPHAGE, DITROPAN, COVERSYL, CATAPRES, FENOFIBRATE. Patient was hospitalized. Patient recovered.

Physician from GERMANY reported TAVANIC problem on May 02, 2006. Male patient, 51 years of age, was diagnosed with pyelonephritis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: extraocular muscle disorder, eye pain, periorbital oedema. TAVANIC dosage: unknown. During the same period patient was treated with ANTIBIOTICS NOS, ROXITHROMYCIN. Patient recovered.

TAVANIC problem was reported by a Health Professional from FRANCE on May 02, 2006. Male patient, 59 years of age, was diagnosed with pneumonia, hiv infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cholestasis. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL, DEPAMIDE, ACETAMINOPHEN, TRIZIVIR, MEPRONIZINE. Patient was hospitalized. Patient recovered.

Pharmacist from GERMANY reported TAVANIC problem on May 08, 2006. Male patient, 77 years of age, was diagnosed with orchitis, hypertension and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cataract, glaucoma, visual field defect. TAVANIC dosage: unknown. During the same period patient was treated with NORVASC, METOBETA. Patient recovered.

TAVANIC problem was reported by a Physician from SOUTH AFRICA on May 10, 2006. Female patient was diagnosed with prophylaxis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: electrolyte imbalance, grand mal convulsion. TAVANIC dosage: unknown. Patient was hospitalized. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on May 09, 2006. Male patient, 30 years of age, was diagnosed with colitis, gastroenteritis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: dyspnoea, orthostatic hypotension, paraesthesia, tetany. TAVANIC dosage: unknown. During the same period patient was treated with BUSCOPAN, MOTILIUM, PERENTEROL. Patient was hospitalized. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on May 11, 2006. Female patient, 62 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: muscle rupture, tendonitis. TAVANIC dosage: unknown. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on May 19, 2006. Female patient, 71 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: multi-organ failure, toxic epidermal necrolysis. TAVANIC dosage: unknown. During the same period patient was treated with CIPROFLOXACIN, FLUMIL, FLUTICASONE PROPIONATE, SALMETEROL XINAFOATE, SPIRIVA, ALLOPURINOL. Patient was hospitalized. Patient died on 03/24/2006.

TAVANIC problem was reported by a Health Professional from JAPAN on May 29, 2006. Male patient, 77 years of age, was diagnosed with epididymitis, orchitis, hypertension and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: visual field defect. TAVANIC dosage: unknown. During the same period patient was treated with NORVASC, METOBETA. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on May 29, 2006. Male patient, 75 years of age, was diagnosed with bronchitis chronic and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: myalgia, visual acuity reduced. TAVANIC dosage: unknown. During the same period patient was treated with CORTICOSTEROIDS. Patient recovered.

TAVANIC problem was reported by a Consumer or non-health professional from on Apr 24, 2006. Male patient, 59 years of age, was diagnosed with pneumonia, bipolar i disorder and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cholestasis, hepatic enzyme increased. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL, DEPAMIDE, ACETAMINOPHEN, TRIZIVIR, MEPRONIZINE, EFFEXOR, STILNOX, EQUANIL. Patient was hospitalized. Patient recovered.



TAVANIC problem was reported by a Health Professional from JAPAN on June 05, 2006. Female patient, 84 years of age, was diagnosed with gastrointestinal disorder and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: hepatitis fulminant, sepsis. TAVANIC dosage: unknown. During the same period patient was treated with LACIMEN, SEROXAT, OMEPRAZOLE, ADIRO, DIANBEN, DIAMICRON. Patient was hospitalized. Patient died on 03/17/2006.

Health Professional from JAPAN reported TAVANIC problem on June 06, 2006. Female patient, 70 years of age, was diagnosed with pneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: hepatic necrosis, hepatitis cholestatic. TAVANIC dosage: unknown. During the same period patient was treated with AUGMENTIN. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on June 06, 2006. Male patient, 51 years of age, was diagnosed with pyelonephritis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: extraocular muscle disorder, eye pain, periorbital oedema. TAVANIC dosage: unknown. During the same period patient was treated with ANTIBIOTICS NOS, ROXITHROMYCIN. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on June 07, 2006. Male patient, 59 years of age, was diagnosed with pneumonia, bipolar i disorder, hiv infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cholestasis. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL, DEPAMIDE, ACETAMINOPHEN, TRIZIVIR, MEPRONIZINE. Patient was hospitalized. Patient recovered.

*TAVANIC problem was reported by a Health Professional from JAPAN on June 06, 2006. Female patient, 35 years of age, was diagnosed with bronchitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: abortion spontaneous, drug exposure during pregnancy. TAVANIC dosage: unknown. During the same period patient was treated with CEFUHEXAL, ACEMUC. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on June 12, 2006. Female patient, 93 years of age, was diagnosed with upper respiratory tract infection, hypertension, atrial fibrillation and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: delirium, disorientation, hallucination, vomiting. TAVANIC dosage: unknown. During the same period patient was treated with TERTENSIF, ADIRO, NITRODERM. Patient recovered.

TAVANIC problem was reported by a Physician from FRANCE on June 16, 2006. Female patient was diagnosed with sigmoiditis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: pruritus, rash. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL. Patient was hospitalized. Patient recovered.

*Health Professional from JAPAN reported TAVANIC problem on June 16, 2006. Male patient, 77 years of age, was diagnosed with essential hypertension and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: myalgia, myositis. TAVANIC dosage: unknown. During the same period patient was treated with NORVASC, CARDURAN, FORTZAAR, LOBIVON. Patient recovered.


Health Professional from JAPAN reported TAVANIC problem on June 27, 2006. Female patient, 84 years of age, was diagnosed with gastrointestinal disorder and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: hepatitis fulminant, sepsis, skin infection. TAVANIC dosage: unknown. During the same period patient was treated with LACIMEN, SEROXAT, OMEPRAZOLE, ADIRO, DIANBEN, DIAMICRON. Patient was hospitalized. Patient died on 03/17/2006.

*TAVANIC problem was reported by a Health Professional from JAPAN on June 27, 2006. Female patient, 63 years of age, was diagnosed with sinusitis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: arthralgia, dyspnoea, gastrointestinal disorder, insomnia, lyme disease, micturition disorder, muscular weakness, tendon disorder, tendonitis. TAVANIC dosage: unknown. During the same period patient was treated with SOLUPRED. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on June 28, 2006. Male patient, 48 years of age, was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: dermatitis exfoliative, dyspnoea, pruritus, rash, wheezing. TAVANIC dosage: unknown. Patient recovered.



*Health Professional from JAPAN reported TAVANIC problem on July 18, 2006. Male patient, 72 years of age, was diagnosed with upper respiratory tract infection, hypertension, benign prostatic hyperplasia, chronic obstructive pulmonary disease, gastric ulcer, gout and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: oedema, skin discolouration, tendonitis. TAVANIC dosage: unknown. During the same period patient was treated with ATENOLOL, PRADIF, ALIFLUS, SINEMET, LANSOPRAZOLE, ALLOPURINOL, AVELOX. Patient recovered.

*TAVANIC problem was reported by a Physician from JAPAN on July 21, 2006. Female patient, 76 years of age, was diagnosed with bronchitis, chronic obstructive pulmonary disease, hypertension and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: disseminated intravascular coagulation, hypothermia, multi-organ failure, septic shock, toxic epidermal necrolysis. TAVANIC dosage: unknown. During the same period patient was treated with MEDROL, ALLOPURINOL, TENORMIN, TRYPTIZOL. Patient was hospitalized. Patient died.

Consumer or non-health professional from reported TAVANIC problem on Aug 07, 2006. Male patient, 36 years of age, weighting 165.3 lb, was diagnosed with pyrexia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, gamma-glutamyltransferase increased. TAVANIC dosage: unknown. During the same period patient was treated with KETEK, AUGMENTIN, DOLIPRANE, NORTUSSINE, MEDROL, NEXIUM. Patient was hospitalized. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Aug 10, 2006. Male patient, 77 years of age, was diagnosed with bronchopneumonia, acute lymphocytic leukaemia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: gastroenteritis. TAVANIC dosage: unknown. During the same period patient was treated with DOXORUBICIN, GENOXAL, VINCRISTINA, MABTHERA. Patient was hospitalized. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Aug 18, 2006. Female patient, 75 years of age, was diagnosed with urinary tract infection and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: cholestasis. TAVANIC dosage: unknown. During the same period patient was treated with PAROXETINE, INSULATARD NPH, LIPITOR, METFORMIN, NITROMEX, ACETAMINOPHEN, STESOLID, IMPUGAN. Patient was hospitalized. Patient recovered.

TAVANIC problem was reported by a Physician from FRANCE on June 16, 2006. Female patient, 68 years of age, was diagnosed with sigmoiditis and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: pruritus, rash maculo-papular. TAVANIC dosage: unknown. During the same period patient was treated with FLAGYL, COTAREG. Patient was hospitalized. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Sept 06, 2006. Female patient, 90 years of age, was diagnosed with pneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: toxic skin eruption. TAVANIC dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, CEFTRIAXONE. Patient died.

TAVANIC problem was reported by a Health Professional from JAPAN on Sept 12, 2006. Female patient, 60 years of age, was diagnosed with large intestine perforation, peritonitis, lip and/or oral cavity cancer and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: anuria, circulatory collapse, dehydration, malaise, renal failure acute. TAVANIC dosage: unknown. During the same period patient was treated with TAZOCILLINE, TRIVASTAL, LEXOMIL, ATENOLOL. Patient was hospitalized. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Sept 12, 2006. Female patient, 73 years of age, was diagnosed with pneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: coordination abnormal, ophthalmoplegia, vomiting. TAVANIC dosage: unknown. Patient recovered.

TAVANIC problem was reported by a Health Professional from JAPAN on Sept 12, 2006. Female patient, 66 years of age, was diagnosed with pneumonia and was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: anosmia, dysgeusia. TAVANIC dosage: unknown. Patient recovered.

Health Professional from JAPAN reported TAVANIC problem on Sept 15, 2006. Female patient was treated with TAVANIC. After drug was administered, patient experienced the following problems/side effects: gastrointestinal disorder. TAVANIC dosage: unknown. Patient was hospitalized. Patient recovered.

*Pharmacist from CANADA reported LEVAQUIN problem on June 23, 2006. Female patient was diagnosed with respiratory disorder and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blindness. LEVAQUIN dosage: unknown. During the same period patient was treated with COMBIVENT, FLOVENT, SPIRIVA, OCUFLOX. Patient recovered.

LEVAQUIN problem was reported by a Health Professional from UNITED STATES on June 27, 2006. Female patient, weighting 249.7 lb, was diagnosed with asthma, chronic obstructive pulmonary disease and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: infusion site urticaria. LEVAQUIN dosage: 500 MG X1 IV. During the same period patient was treated with ALBUTEROL SPIROS, DUONEB. Patient was hospitalized. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 03, 2006. Female patient, 70 years of age, weighting 125.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: contusion, pain in extremity, tendon disorder, tendon rupture. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on June 27, 2006. Female patient, weighting 130.0 lb, was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: ageusia. LEVAQUIN dosage: unknown. Patient recovered.

*Physician from CANADA reported LEVAQUIN problem on June 28, 2006. Male patient was diagnosed with pneumonia, anticoagulant therapy, gastrooesophageal reflux disease, musculoskeletal pain and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blindness, drug administration error, macular degeneration, overdose, visual field defect. LEVAQUIN dosage: unknown. During the same period patient was treated with HEPARIN, OMEPRAZOLE, ACETAMINOPHEN, NITROGLYCERIN, LORAZEPAM, SALINE, VITAMIN E. Patient was hospitalized and became disabled. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 07, 2006. Male patient, 35 years of age, weighting 185.0 lb, was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, arthralgia, body temperature decreased, depression, feeling cold, nervous system disorder, panic attack, tendon disorder. LEVAQUIN dosage: unknown. During the same period patient was treated with CIPRO. Patient recovered.

Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 07, 2006. Male patient, 40 years of age, weighting 155.0 lb, was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, heart rate increased, insomnia, joint swelling. LEVAQUIN dosage: 500MG 1 PER DAY PO. Patient recovered.

*LEVAQUIN problem was reported by a Health Professional from UNITED STATES on July 07, 2006. Female patient, 20 years of age, weighting 140.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: abasia, anaphylactic reaction, asthenia, burning sensation, chest discomfort, chest pain, cold sweat, confusional state, drug ineffective. LEVAQUIN dosage: unknown. Patient recovered.

Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 05, 2006. Female patient, weighting 140.0 lb, was diagnosed with ear infection, pharyngitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: neurotoxicity, pain. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on July 05, 2006. Female patient, 71 years of age, weighting 262.4 lb, was diagnosed with escherichia urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: rash erythematous, urticaria. LEVAQUIN dosage: 500 MG QDAY IV [1 DOSE]. Patient recovered.

Pharmacist from UNITED STATES reported LEVAQUIN problem on July 06, 2006. Male patient, 71 years of age, weighting 210.0 lb, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, arrhythmia, chest discomfort, myalgia, pain in extremity, paraesthesia, sinus tachycardia. LEVAQUIN dosage: 500 MG QD PO. Patient recovered.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on June 30, 2006. Female patient, 18 years of age, was diagnosed with antibiotic prophylaxis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: delirium. LEVAQUIN dosage: unknown. Patient was hospitalized. Patient recovered.

*Physician from UNITED STATES reported LEVAQUIN problem on July 06, 2006. Female patient was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, arthralgia, connective tissue disorder, dyspnoea, facial pain, nervous system disorder, polyneuropathy, tendon disorder, tendonitis. LEVAQUIN dosage: unknown. During the same period patient was treated with PREDNISONE. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 05, 2006. Female patient, weighting 125.0 lb, was diagnosed with pneumonia, anticoagulant therapy, blood cholesterol decreased, blood pressure and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: hallucination, incorrect dose administered. LEVAQUIN dosage: unknown. During the same period patient was treated with PLAVIX, LOVASTATIN, LISINOPRIL, NICARDIPINE, DIPYRIDAMOLE. Patient was hospitalized. Patient recovered.

Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 05, 2006. Male patient was diagnosed with infection, wound infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: abdominal pain, blood creatinine increased, blood potassium decreased, blood sodium increased, clostridium difficile colitis, colitis ischaemic, constipation, cutaneous anthrax. LEVAQUIN dosage: unknown. During the same period patient was treated with LEVOFLOXACIN, STOOL SOFTNER, NORVASC, METOPROLOL TARTRATE, METRONIDAZOLE, VANCOMYCIN. Patient was hospitalized. Patient died on 03/15/2005.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on July 14, 2006. Female patient, 90 years of age, weighting 125.0 lb, was diagnosed with cellulitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: erythema, infusion site reaction, pruritus. LEVAQUIN dosage: 250 MG Q 24 HOURS IV. During the same period patient was treated with FUROSEMIDE, DIOVAN, SYNTHROID, TOPROL, COUMADIN. Patient recovered.

*Pharmacist from UNITED STATES reported LEVAQUIN problem on July 11, 2006. Female patient, 31 years of age, weighting 199.2 lb, was diagnosed with acute sinusitis, seasonal allergy and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: neuropathy peripheral. LEVAQUIN dosage: unknown. During the same period patient was treated with ALLEGRA, FLONASE. Patient recovered.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on July 17, 2006. F emale patient, 82years of age, weighting 145.5 lb, was diagnosed with escherichia urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: hypoglycaemia. LEVAQUIN dosage: 250MG ONCE DAILY PO. During the same period patient was treated with DILTIAZEM, ATENOLOL, LISINOPRIL, PRILOSEC, VITAMIN, LEVOTHYROXINE, FUROSEMIDE, POTASSIUM. Patient recovered.

Health Professional from UNITED STATES reported LEVAQUIN problem on July 17, 2006. Female patient was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: dyspnoea, flushing, nasopharyngeal disorder, pruritus, wrong drug administered. LEVAQUIN dosage: 500 MG DAILY PO [ONE DOSE]. Patient recovered.

LEVAQUIN problem was reported by a Physician from UNITED STATES on July 14, 2006. Female patient, 95 years of age, was diagnosed with sepsis, pneumonia and was treated with LEVAQUIN. LEVAQUIN dosage: unknown. Patient was hospitalized. Patient died.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 20, 2006. Female patient, weighting 120.0 lb, was diagnosed with productive cough and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: gait disturbance, tendonitis. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 19, 2006. Female patient was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: cardiac arrest, drug interaction. LEVAQUIN dosage: unknown. During the same period patient was treated with BETAPACE. Patient was hospitalized. Patient recovered.

Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 18, 2006. Male patient, 57 years of age, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blindness transient, eructation, hyperhidrosis, hypotension. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 17, 2006. Female patient, weighting 205.0 lb, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, diarrhoea, disturbance in attention, dyspnoea, fatigue, headache, hyperhidrosis, insomnia, lymphoma. LEVAQUIN dosage: unknown. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 19, 2006. Female patient, weighting 120.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: back pain, meniscus lesion, palpitations. LEVAQUIN dosage: unknown. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 19, 2006. Male patient, weighting 203.0 lb, was diagnosed with infection prophylaxis, postoperative infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, arthralgia, asthenia, depression, dysstasia, fatigue, gait disturbance, neuropathy peripheral, pain. LEVAQUIN dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.
*Physician from UNITED STATES reported LEVAQUIN problem on July 20, 2006. Female patient, weighting 222.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, arthropathy, back pain, bursitis, drug hypersensitivity, therapy non-responder. LEVAQUIN dosage: unknown. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 25, 2006. Female patient, 57 years of age, weighting 137.0 lb, was diagnosed with acute sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthritis, mobility decreased, multiple sclerosis, rheumatoid arthritis, tendon disorder. LEVAQUIN dosage: 500 MG ONCE DAILY. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 24, 2006. Female patient, 35 years of age, weighting 110.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: back pain, joint sprain, ligament disorder, neck pain, polyarthritis, tendon disorder. LEVAQUIN dosage: 500MG ONCE A DAY PO. Patient recovered.

*LEVAQUIN problem was reported by a Physician from UNITED STATES on July 20, 2006. Male patient, weighting 180.0 lb, was diagnosed with prostatitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: gait disturbance, muscle injury, pain in extremity. LEVAQUIN dosage: unknown. During the same period patient was treated with LASIX, POTASSIUM, COZAAR, ZETIA, SIMVASTATIN, TOMOPTIC. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 24, 2006. Female patient, 39 years of age, weighting 189.0 lb, was diagnosed with upper respiratory tract infection, urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, arthritis, back pain, gait disturbance, musculoskeletal chest pain, musculoskeletal pain, neck pain, pain in extremity. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 26, 2006. Female patient, 77 years of age, weighting 126.0 lb, was diagnosed with diverticulitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: adverse drug reaction. LEVAQUIN dosage: 500MG EVERY 24 HOURS I.V.. Patient recovered.

Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 26, 2006. Female patient, weighting 113.0 lb, was diagnosed with vulval disorder and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: urticaria. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on July 27, 2006. Male patient, weighting 175.0 lb, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, cardio-respiratory arrest, electromechanical dissociation, ventricular fibrillation. LEVAQUIN dosage: 500 MG ONCE IV DRIP. Patient died on 07/06/2006.

*Health Professional from JAPAN reported LEVAQUIN problem on July 20, 2006. Female patient, 52 years of age, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, arthralgia, connective tissue disorder, dyspnoea, facial pain, myalgia, nervous system disorder, peripheral nerve injury, polyneuropathy. LEVAQUIN dosage: unknown. During the same period patient was treated with PREDNISONE. Patient recovered.

LEVAQUIN problem was reported by a Pharmacist from UNITED STATES on July 28, 2006. Male patient, 65 years of age, was diagnosed with infection, diabetes mellitus non-insulin-dependent and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: confusional state, gangrene, hypoglycaemia, post procedural complication, toe amputation. LEVAQUIN dosage: 500MG DAILY IV (3 DOSES). During the same period patient was treated with GLIMEPIRIDE. Patient was hospitalized. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on July 28, 2006. Male patient, 46 years of age, weighting 170.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, pain in extremity, similar reaction on previous exposure to drug. LEVAQUIN dosage: 500 MG ONCE PO. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on July 31, 2006. Male patient, 73 years of age, weighting 150.0 lb, was diagnosed with skin infection, urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: convulsion, delusion, dysstasia, gait disturbance, hyperhidrosis. LEVAQUIN dosage: 100 MG 1. During the same period patient was treated with SINEMET, SINEMET CR, ZOLOFT, AEROSEPT, PAMALOR, ASPIRIN, BASOTECH. Patient was hospitalized. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 02, 2006. Female patient, 31 years of age, weighting 220.0 lb, was diagnosed with incision site infection, postoperative infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, depression, gait disturbance, impaired work ability, insomnia, mental disorder, tendonitis. LEVAQUIN dosage: 500MG 1X PER DAY PO. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 03, 2006. Female patient, 44 years of age, weighting 165.0 lb, was diagnosed with diverticulitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: abnormal dreams, agitation, arthralgia, asthenia, catheter related complication, confusional state, decreased appetite, feeling abnormal, grip strength decreased. LEVAQUIN dosage: unknown. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 03, 2006. Female patient, 40 years of age, weighting 158.0 lb, was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: amnesia, arthralgia, asthenia, confusional state, fibromyalgia, insomnia, irritable bowel syndrome, muscle twitching, pain. LEVAQUIN dosage: unknown. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 03, 2006. Female patient, weighting 155.0 lb, was diagnosed with crohn's disease and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: hypokinesia, musculoskeletal pain, pain in extremity. LEVAQUIN dosage: 500MG 1 DAY PO. Patient recovered.

Physician from UNITED STATES reported LEVAQUIN problem on July 31, 2006. Male patient was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: erythema nodosum. LEVAQUIN dosage: unknown. During the same period patient was treated with CIPROFLOXACIN. Patient was hospitalized. Patient recovered.

LEVAQUIN problem was reported by a Physician from UNITED STATES on Aug 01, 2006. Female patient was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: soft tissue necrosis, stevens-johnson syndrome. LEVAQUIN dosage: unknown. Patient was hospitalized. Patient recovered.

*Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 03, 2006. Female patient, weighting 155.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: disturbance in attention, drug ineffective, flushing, head discomfort, insomnia, paraesthesia, peripheral coldness, retinal vein occlusion, skin burning sensation. LEVAQUIN dosage: unknown. Patient recovered.

*LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 03, 2006. Female patient, 44 years of age, weighting 230.0 lb, was diagnosed with infection prophylaxis, postoperative care and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, back pain, myalgia, therapy non-responder. LEVAQUIN dosage: 500MG 1 PER DAY PO. Patient recovered.

Health Professional from UNITED STATES reported LEVAQUIN problem on Aug 07, 2006. Female patient, 57 years of age, weighting 201.0 lb, was diagnosed with preoperative care and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: infusion related reaction, pruritus. LEVAQUIN dosage: 500MG IV. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 07, 2006. Female patient, 63 years of age, weighting 179.0 lb, was diagnosed with urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: asthenia, blood glucose decreased, burning sensation, dizziness, dyspepsia, emotional distress, feeling abnormal, pain, urinary tract infection. LEVAQUIN dosage: 500 MG ONCE DAY MOUTH. During the same period patient was treated with CIPRO. Patient recovered.

Health Professional from UNITED STATES reported LEVAQUIN problem on Aug 07, 2006. Female patient, 47 years of age, was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: chest discomfort, oedema peripheral. LEVAQUIN dosage: unknown. Patient recovered.

LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 10, 2006. Male patient, 32 years of age, weighting 205.0 lb, was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: pharyngeal oedema, urticaria. LEVAQUIN dosage: 500 MG ONCE A DAY PO. Patient was hospitalized. Patient recovered.

• Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 09, 2006. Female patient, 47 years of age, weighting 160.0 lb, was diagnosed with bronchitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, cough, dizziness, ear pain, facial pain, gait disturbance, headache, insomnia, joint effusion. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 09, 2006. Female patient, 77 years of age, weighting 155.0 lb, was diagnosed with pneumonia bacterial and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, arthralgia, contraindication to medical treatment, feeling of despair, myalgia, pain, pain in extremity. LEVAQUIN dosage: 500 MG DAILY IV + TABLETS. During the same period patient was treated with VANCOMYCIN, OXYGEN, BENADRYL, CORTISONE. Patient was hospitalized and became disabled. Patient recovered.
  
  Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 11, 2006. Male patient, 28 years of age, weighting 165.0 lb, was diagnosed with localised infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: diarrhoea, nausea. LEVAQUIN dosage: 750MG QD PO. Patient recovered.
  
  *LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 14, 2006. Female patient, 42 years of age, weighting 180.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: back pain, drug ineffective, gait disturbance. LEVAQUIN dosage: 500 MG 1 TABLET DAILY PO. Patient recovered.
  
  *Physician from UNITED STATES reported LEVAQUIN problem on Aug 15, 2006. Female patient was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: tendon rupture. LEVAQUIN dosage: 500 MG #10 ONE DAILY PO. Patient was hospitalized. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 16, 2006. Female patient, weighting 145.0 lb, was diagnosed with pneumonia, bronchitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blood pressure decreased, bronchitis, colitis, nausea, urticaria. LEVAQUIN dosage: unknown. Patient recovered.
  
  *Physician from UNITED STATES reported LEVAQUIN problem on Aug 07, 2006. Female patient, weighting 132.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: angioneurotic oedema, arthralgia, connective tissue disorder, dyspnoea, facial pain, fatigue, myalgia, nervous system disorder, polyneuropathy. LEVAQUIN dosage: unknown. During the same period patient was treated with PREDNISONE. Patient recovered.
  
  *LEVAQUIN problem was reported by a Health Professional from UNITED STATES on Aug 17, 2006. Female patient, 63 years of age, weighting 140.0 lb, was diagnosed with respiratory tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: neuropathy peripheral. LEVAQUIN dosage: 500 MG -1 TABLET DAILY PO. Patient recovered.
  *Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 18, 2006. Female patient, 48 years of age, weighting 290.0 lb, was diagnosed with urinary tract infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, fear, incontinence, memory impairment, middle insomnia, muscle contractions involuntary, muscle tightness, muscle twitching, musculoskeletal stiffness. LEVAQUIN dosage: 1 PILL OF 750 MG 1/2 PILL 325 MG PO. Patient recovered.
  
  *LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 21, 2006. Female patient, 46 years of age, weighting 155.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, arthralgia, blood glucose fluctuation, dizziness, heart rate increased, malaise, nightmare, tendon disorder, tremor. LEVAQUIN dosage: unknown. Patient was hospitalized. Patient recovered.
  
  *Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 22, 2006. Female patient, weighting 168.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: amnesia, arthralgia, dizziness, fatigue. LEVAQUIN dosage: 750 MG DAILY ORAL. During the same period patient was treated with VERAPAMIL, PRILOSEC, SYNTHROID, TOPAMAX, NORTRIPTYLINE, SINGULAIR. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 23, 2006. Female patient, 58 years of age, weighting 235.0 lb, was diagnosed with kidney infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: anxiety, asthenia, asthma, dyspnoea, increased bronchial secretion, joint lock, medication error, photophobia, stress. LEVAQUIN dosage: unknown. Patient recovered.
  
  *Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 22, 2006. Female patient, 34 years of age, weighting 120.0 lb, was diagnosed with incision site infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: fear, headache, hypoaesthesia, pain in extremity, paraesthesia. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 23, 2006. Female patient, 30 years of age, weighting 200.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: depression, insomnia, nausea, panic attack, suicidal ideation. LEVAQUIN dosage: 1 500 MG PILL ONCE A DAY PO. Patient recovered.
  
  Physician from UNITED STATES reported LEVAQUIN problem on Aug 17, 2006. Male patient was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: hallucination, psychotic disorder. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Physician from UNITED STATES on Aug 18, 2006. Female patient was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: pneumonia. LEVAQUIN dosage: unknown. Patient died.
  
  Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 25, 2006. Female patient, 45 years of age, weighting 113.0 lb, was diagnosed with bacterial infection, gastrointestinal infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: heart rate increased, hypoaesthesia, insomnia, nausea, nightmare, nocturia, palpitations. LEVAQUIN dosage: 500 MG ONCE DAILY. Patient recovered.
  
  LEVAQUIN problem was reported by a Physician from UNITED STATES on Aug 18, 2006. Male patient, 73 years of age, was diagnosed with infection prophylaxis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: bacteraemia, prostatic specific antigen increased, sepsis. LEVAQUIN dosage: unknown. Patient was hospitalized. Patient recovered.
  
  *Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Aug 30, 2006. Male patient, 51 years of age, weighting 220.0 lb, was diagnosed with drug ineffective, sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, burning sensation, decreased activity, grip strength decreased, hypoaesthesia, hypoaesthesia oral, muscle twitching, musculoskeletal pain, pain in extremity. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 31, 2006. Female patient, 57 years of age, weighting 116.0 lb, was diagnosed with cellulitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: pruritus, rash, refusal of treatment by patient, secretion discharge, therapy non-responder, urticaria. LEVAQUIN dosage: 500 MG ONCE A DAY PO. Patient recovered.
  
  Physician from UNITED STATES reported LEVAQUIN problem on Aug 22, 2006. Male patient was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: erythema nodosum. LEVAQUIN dosage: unknown. During the same period patient was treated with CIPROFLOXACIN. Patient was hospitalized. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Aug 22, 2006. Female patient, 69 years of age, weighting 205.0 lb, was diagnosed with postoperative infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: retinal detachment. LEVAQUIN dosage: unknown. During the same period patient was treated with THROMBIN, HEPARIN. Patient recovered.
  
  *Physician from UNITED STATES reported LEVAQUIN problem on Aug 23, 2006. Male patient, weighting 350.0 lb, was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: drug hypersensitivity, generalised oedema, hypothyroidism, rheumatoid arthritis, thyroid disorder. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Physician from UNITED STATES on Aug 24, 2006. Female patient was treated with LEVAQUIN. LEVAQUIN dosage: unknown. Patient died on 08/08/2006.
  
  Physician from UNITED STATES reported LEVAQUIN problem on Aug 24, 2006. Female patient was diagnosed with preoperative care and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: paralysis, respiratory arrest. LEVAQUIN dosage: unknown. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 05, 2006. Male patient, 38 years of age, weighting 192.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blister, eyelids pruritus, rash, swelling. LEVAQUIN dosage: 750 MG 1X DAILY PO. Patient recovered.
  
  Health Professional from UNITED STATES reported LEVAQUIN problem on Sept 05, 2006. Male patient, 35 years of age, weighting 180.0 lb, was diagnosed with prostate infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: constipation. LEVAQUIN dosage: 500 MG 1 DAILY PO. Patient was hospitalized. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional *from UNITED STATES on Sept 06, 2006. Female patient, 51 years of age, weighting 290.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, mobility decreased, musculoskeletal pain, nightmare, pruritus generalised, thinking abnormal. LEVAQUIN dosage: unknown. Patient recovered.
  
  *Health Professional from UNITED STATES reported LEVAQUIN problem on Sept 06, 2006. Male patient, 38 years of age, weighting 205.0 lb, was diagnosed with prostatitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: arthralgia, bradycardia, cardiac disorder, dizziness, hyperhidrosis, nausea, neuropathy, palpitations, ventricular extrasystoles. LEVAQUIN dosage: unknown. Patient was hospitalized and became disabled. Patient recovered.
  
  LEVAQUIN problem was reported by a Physician from UNITED STATES on Sept 07, 2006. Female patient, 76 years of age, weighting 110.0 lb, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: blood glucose decreased. LEVAQUIN dosage: 500 MG DAILY PO. Patient was hospitalized. Patient recovered.
  
  *Health Professional from UNITED STATES reported LEVAQUIN problem on Sept 07, 2006. Female patient, 48 years of age, weighting 195.0 lb, was diagnosed with infection and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: muscle strain, pain in extremity, periarthritis, rotator cuff syndrome, tendonitis. LEVAQUIN dosage: 500 MG DAILY PO. Patient recovered.
  
  LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 11, 2006. Female patient, 79 years of age, weighting 145.0 lb, was diagnosed with bladder disorder and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: no adverse effect. LEVAQUIN dosage: unknown. Patient recovered.
  
  *Consumer or non-health professional from UNITED STATES reported LEVAQUIN problem on Sept 12, 2006. Male patient, 73 years of age, weighting 174.0 lb, was diagnosed with sinusitis and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: ill-defined disorder, joint instability, medical device complication, tendonitis. LEVAQUIN dosage: 500MG TAB 1 DAILY X 10 DAYS PO. During the same period patient was treated with DELESTYRL, XALATAN, GLUCOPHAGE, ASPIRIN. Patient recovered.
  
  *LEVAQUIN problem was reported by a Consumer or non-health professional from UNITED STATES on Sept 12, 2006. Female patient, 42 years of age, weighting 175.0 lb, was diagnosed with pneumonia and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: depression, fatigue, ill-defined disorder, impaired work ability, sciatica, tendonitis, therapeutic response decreased. LEVAQUIN dosage: unknown. Patient recovered.
  
  Physician from UNITED STATES reported LEVAQUIN problem on Sept 07, 2006. Female patient, weighting 150.0 lb, was diagnosed with pneumonia, bronchitis, infection, pain and was treated with LEVAQUIN. After drug was administered, patient experienced the following problems/side effects: leukocytoclastic vasculitis, mitral valve stenosis, pyrexia. LEVAQUIN dosage: unknown. During the same period patient was treated with