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List of genes that are affected by
quinolones.
List of genes that interact with quinolones.
List of which organisms that this quinlone-gene interaction been
studied.
List of which cellular functions (GO terms) that are affected by the
quinolones.
Gene Name A230062G08Rik
Synonyms 2-AMINOADIPIC 6-SEMIALDEHYDE DEHYDROGENASE
AASDH
MUS MUSCULUS 10 DAYS NEONATE CORTEX CDNA, RIKEN FULL-LENGTH ENRICHED
LIBRARY, CLONE:A830035E16 PRODUCT:HYPOTHETICAL AMP-DEPENDENT
SYNTHETASE AND LIGASE CONTAINING PROTEIN, FULL INSERT SEQUENCE
Molecular Function
L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043] 1
organism, 1 sequence
catalytic activity [GO:0003824] 1 organism, 2 sequences
cofactor binding [GO:0048037] 1 organism, 1 sequence
ligase activity [GO:0016874] 1 organism, 1 sequence
oxidoreductase activity [GO:0016491] 1 organism, 1 sequence
Biological Process
electron transport [GO:0006118] 1 organism, 1 sequence
fatty acid metabolism [GO:0006631] 1 organism, 1 sequence
lipid metabolism [GO:0006629] 1 organism, 1 sequence
metabolism [GO:0008152]
Gene Name AASDH
Synonyms 2-AMINOADIPIC 6-SEMIALDEHYDE DEHYDROGENASE
AASDH PROTEIN
Gene Name ABCB1
Synonyms ABCB1B
ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 1
ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY B, MEMBER 1
CD243 ANTIGEN
MDR1
MDR1B
MULTI-DRUG RESISTANCE P-GLYCOPROTEIN 1
MULTI-DRUG RESISTANCE PROTEIN 1
MULTIDRUG RESISTANCE PROTEIN 1
P-GLYCOPROTEIN
P-GLYCOPROTEIN 1
PGP1
PGY1
PGY1-1
Molecular Function ATP binding [GO:0005524] 9 organisms, 10 sequences
ATPase activity [GO:0016887] 9 organisms, 10 sequences
ATPase activity, coupled to transmembrane movement of substances
[GO:0042626] 8 organisms, 9 sequences
nucleoside-triphosphatase activity [GO:0017111] 8 organisms, 9
sequences
nucleotide binding [GO:0000166] 8 organisms, 9 sequences
transporter activity [GO:0005215] 2 organisms, 2 sequences
Biological Process response to drug [GO:0042493] 1 organism, 1
sequence
transport [GO:0006810] 8 organisms, 9 sequences
Cellular Component inner membrane [GO:0019866] 1 organism, 1 sequence
integral to membrane [GO:0016021] 8 organisms, 9 sequences
intercellular canaliculus [GO:0046581] 1 organism, 1 sequence
membrane [GO:0016020] 2 organisms, 2 sequences
membrane fraction [GO:0005624] 1 organism, 1 sequence
mitochondrion [GO:0005739] 1 organism, 1 sequence
Gene Name ABCC1 (ATP-binding cassette, sub-family C (CFTR/MRP), member
1)
Synonyms ABC29
ATP-BINDING CASSETTE PROTEIN C1
ATP-BINDING CASSETTE, SUB-FAMILY C (CFTR/MRP), MEMBER 1 (MULTIPLE DRUG
RESISTANCE-ASSOCIATED PROTEIN)
ATP-BINDING CASSETTE, SUB-FAMILY C, MEMBER 1
AVCC1A
CONJUGATE EXPORT PUMP PROTEIN
GS-X
MDRAP
MRP-1
MRP1
MULTIPLE DRUG RESISTANCE PROTEIN 1
MULTIPLE DRUG RESISTANCE-ASSOCIATED PROTEIN
Molecular Function ATP binding [GO:0005524] 8 organisms, 25 sequences
ATPase activity [GO:0016887] 6 organisms, 21 sequences
ATPase activity, coupled to transmembrane movement of substances
[GO:0042626] 8 organisms, 21 sequences
homoaconitate hydratase activity [GO:0004409] 1 organism, 1 sequence
nucleoside-triphosphatase activity [GO:0017111] 6 organisms, 18
sequences
nucleotide binding [GO:0000166] 6 organisms, 18 sequences
protein kinase activity [GO:0004672] 1 organism, 1 sequence
transporter activity [GO:0005215] 6 organisms, 14 sequences
Biological Process protein amino acid phosphorylation [GO:0006468] 1
organism, 1 sequence
response to drug [GO:0042493] 1 organism, 1 sequence
transport [GO:0006810] 8 organisms, 21 sequences
Cellular Component integral to membrane [GO:0016021] 8 organisms, 21
sequences
integral to plasma membrane [GO:0005887] 2 organisms, 5 sequences
membrane fraction [GO:0005624] 1 organism, 1 sequence
Gene Name ABCC2 (ATP-binding cassette, sub-family C (CFTR/MRP), member
2)
Synonyms ABC30
CANALICULAR MULTIDRUG RESISTANCE PROTEIN
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER CMOAT
CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER 1
CMOAT
CMOAT PROTEIN
CMOAT1
CMRP
DJS
EBCR
EPITHELIAL BASOLATERAL CHLORIDE CONDUCTANCE REGULATOR
MRP-2
MRP2
MULTIDRUG RESISTANCE RELATED PROTEIN 2
MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2
P-GLYCOPROTEIN 2
P-GLYCOPROTEIN 3
PGP3
PGY2
Molecular Function ATP binding [GO:0005524] 12 organisms, 21 sequences
ATPase activity [GO:0016887] 11 organisms, 19 sequences
ATPase activity, coupled to transmembrane movement of substances
[GO:0042626] 10 organisms, 16 sequences
nucleoside-triphosphatase activity [GO:0017111] 9 organisms, 15
sequences
nucleotide binding [GO:0000166] 9 organisms, 15 sequences
organic anion transporter activity [GO:0008514] 2 organisms, 2
sequences
protein binding [GO:0005515] 1 organism, 5 sequences
transporter activity [GO:0005215] 9 organisms, 15 sequences
Biological Process organic anion transport [GO:0015711] 1 organism, 1
sequence
transport [GO:0006810] 10 organisms, 16 sequences
Cellular Component apical plasma membrane [GO:0016324] 1 organism, 5
sequences
inner membrane [GO:0019866] 1 organism, 1 sequence
integral to membrane [GO:0016021] 10 organisms, 16 sequences
integral to plasma membrane [GO:0005887] 2 organisms, 6 sequences
intercellular canaliculus [GO:0046581] 1 organism, 5 sequences
membrane [GO:0016020] 2 organisms, 2 sequences
mitochondrion [GO:0005739] 1 organism, 1 sequence
Gene Name Amine oxidase
Synonym COPPER-CONTAINING
Molecular Function amine oxidase activity [GO:0008131] 1 organism, 1
sequence
Gene Name AVP
Synonyms ARGININE VASOPRESSIN
ARGININE VASOPRESSIN-NEUROPHYSIN II PRECURSOR
ARGININE VASOPRESSIN-NEUROPHYSIN II PREPROPROTEIN
ARVP
AVP-NPII
E-NP
NEUROPHYSIN 2
NEUROPHYSIN-II
VASOPRESSIN-NEUROPHYSIN 2 PRECURSOR
VASOPRESSIN-NEUROPHYSIN 2-COPEPTIN PRECURSOR
VP
Molecular Function hormone activity [GO:0005179] 8 organisms, 8
sequences
neurohypophyseal hormone activity [GO:0005185] 10 organisms, 10
sequences
neuropeptide hormone activity [GO:0005184] 1 organism, 1 sequence
receptor binding [GO:0005102] 1 organism, 1 sequence
Biological Process cell-cell signaling [GO:0007267] 1 organism, 1
sequence
generation of precursor metabolites and energy [GO:0006091] 1
organism, 1 sequence
regulation of blood pressure [GO:0008217] 8 organisms, 8 sequences
signal transduction [GO:0007165] 1 organism, 1 sequence
water transport [GO:0006833] 1 organism, 1 sequence
Cellular Component extracellular region [GO:0005576] 10 organisms, 10
sequences
extracellular space [GO:0005615] 1 organism, 1 sequence
soluble fraction [GO:0005625] 1 organism, 1 sequence
Gene Name AVPR1A
Synonyms ANTIDIURETIC HORMONE RECEPTOR 1A
ARGININE VASOPRESSIN RECEPTOR 1A
AVPR V1A
AVPR1
V1AR
VASCULAR/HEPATIC-TYPE ARGININE VASOPRESSIN RECEPTOR
VASOPRESSIN V1A RECEPTOR
Molecular Function G-protein coupled receptor activity [GO:0004930] 6
organisms, 6 sequences
protein kinase C binding [GO:0005080] 1 organism, 1 sequence
receptor activity [GO:0004872] 6 organisms, 6 sequences
rhodopsin-like receptor activity [GO:0001584] 6 organisms, 6 sequences
signal transducer activity [GO:0004871] 6 organisms, 6 sequences
vasopressin receptor activity [GO:0005000] 6 organisms, 6 sequences
Biological Process G-protein coupled receptor protein signaling
pathway [GO:0007186] 6 organisms, 6 sequences
circulation [GO:0008015] 1 organism, 1 sequence
generation of precursor metabolites and energy [GO:0006091] 1
organism, 1 sequence
phospholipase C activation [GO:0007202] 1 organism, 1 sequence
positive regulation of cytosolic calcium ion concentration
[GO:0007204] 1 organism, 1 sequence
signal transduction [GO:0007165] 6 organisms, 6 sequences
Cellular Component endosome [GO:0005768] 1 organism, 1 sequence
integral to membrane [GO:0016021] 6 organisms, 6 sequences
integral to plasma membrane [GO:0005887] 1 organism, 1 sequence
plasma membrane [GO:0005886] 1 organism, 1 sequence
Gene Name BAX
Synonyms APOPTOSIS REGULATOR BAX, CYTOPLASMIC ISOFORM BETA
APOPTOSIS REGULATOR BAX, MEMBRANE ISOFORM ALPHA
APOPTOSIS REGULATOR BAX-ALPHA
BAX ISOFORM PSI
BAX PROTEIN
BAX PROTEIN, CYTOPLASMIC ISOFORM DELTA
BAX PROTEIN, CYTOPLASMIC ISOFORM GAMMA
BAX-PROTEIN
BCL-2 ASSOCIATED PROTEIN
BCL-2 ASSOCIATED X PROTEIN
BCL2-ASSOCIATED PROTEIN BAX
BCL2-ASSOCIATED X
BCL2-ASSOCIATED X PROTEIN
BCL2-ASSOCIATED X PROTEIN ISOFORM SIGMA
Molecular Function protein binding [GO:0005515] 1 organism, 2
sequences
Biological Process apoptosis [GO:0006915] 9 organisms, 15 sequences
apoptotic mitochondrial changes [GO:0008637] 2 organisms, 6 sequences
caspase activation via cytochrome c [GO:0008635] 2 organisms, 3
sequences
cell cycle [GO:0007049] 1 organism, 1 sequence
cellular respiration [GO:0045333] 1 organism, 1 sequence
germ cell development [GO:0007281] 1 organism, 4 sequences
induction of apoptosis [GO:0006917] 2 organisms, 6 sequences
induction of apoptosis by extracellular signals [GO:0008624] 2
organisms, 6 sequences
induction of apoptosis by intracellular signals [GO:0008629] 1
organism, 2 sequences
inner mitochondrial membrane organization and biogenesis [GO:0007007]
1 organism, 1 sequence
negative regulation of cell cycle [GO:0045786] 1 organism, 1 sequence
negative regulation of fibroblast proliferation [GO:0048147] 1
organism, 2 sequences
negative regulation of survival gene product activity [GO:0008634] 1
organism, 4 sequences
neurogenesis [GO:0007399] 1 organism, 2 sequences
nuclear fragmentation [GO:0030264] 1 organism, 2 sequences
outer mitochondrial membrane organization and biogenesis [GO:0007008]
1 organism, 1 sequence
protein homooligomerization [GO:0051260] 1 organism, 2 sequences
protein insertion into mitochondrial membrane during induction of
apoptosis [GO:0001844] 1 organism, 2 sequences
regulation of apoptosis [GO:0042981] 13 organisms, 18 sequences
regulation of caspase activation [GO:0043026] 1 organism, 2 sequences
release of cytochrome c from mitochondria [GO:0001836] 1 organism, 2
sequences
response to DNA damage stimulus [GO:0006974] 1 organism, 2 sequences
response to wounding [GO:0009611] 1 organism, 2 sequences
retinal programmed cell death [GO:0046666] 1 organism, 2 sequences
Cellular Component cytosol [GO:0005829] 1 organism, 2 sequences
integral to membrane [GO:0016021] 6 organisms, 7 sequences
mitochondrial outer membrane [GO:0005741] 1 organism, 2 sequences
Gene Name BIRC5
Synonyms API4
APOPTOSIS INHIBITOR 4
APOPTOSIS INHIBITOR SURVIVIN
BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5
BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 ISOFORM 2
BIRC5 PROTEIN
IAP4
TIAP
Molecular Function caspase inhibitor activity [GO:0043027] 5
organisms, 5 sequences
cysteine protease inhibitor activity [GO:0004869] 5 organisms, 6
sequences
endopeptidase inhibitor activity [GO:0004866] 5 organisms, 6 sequences
microtubule binding [GO:0008017] 5 organisms, 5 sequences
protease inhibitor activity [GO:0030414] 5 organisms, 5 sequences
zinc ion binding [GO:0008270] 5 organisms, 5 sequences
Biological Process G2/M transition of mitotic cell cycle [GO:0000086]
1 organism, 1 sequence
anti-apoptosis [GO:0006916] 5 organisms, 6 sequences
apoptosis [GO:0006915] 5 organisms, 6 sequences
embryonic development [GO:0009790] 1 organism, 1 sequence
microtubule cytoskeleton organization and biogenesis [GO:0000226] 1
organism, 1 sequence
Cellular Component cytoplasm [GO:0005737] 2 organisms, 2 sequences
intracellular [GO:0005622] 5 organisms, 6 sequences
spindle microtubule [GO:0005876]
Gene Name Catnb
Synonyms CATENIN BETA
CATNB PROTEIN
Molecular Function DNA binding [GO:0003677] 1 organism, 1 sequence
alpha-catenin binding [GO:0045294] 1 organism, 1 sequence
binding [GO:0005488] 1 organism, 1 sequence
cadherin binding [GO:0045296] 1 organism, 1 sequence
protein binding [GO:0005515] 1 organism, 1 sequence
transcription coactivator activity [GO:0003713] 1 organism, 1 sequence
transcription factor activity [GO:0003700] 1 organism, 1 sequence
Biological Process Wnt receptor signaling pathway [GO:0016055] 1
organism, 1 sequence
cell maturation [GO:0048469] 1 organism, 1 sequence
cellular physiological process [GO:0050875] 1 organism, 1 sequence
dorsal/ventral axis specification [GO:0009950] 1 organism, 1 sequence
ectoderm development [GO:0007398] 1 organism, 1 sequence
embryonic arm morphogenesis [GO:0035117] 1 organism, 1 sequence
embryonic digit morphogenesis [GO:0042733] 1 organism, 1 sequence
embryonic hindlimb morphogenesis [GO:0035116] 1 organism, 1 sequence
gastrulation (sensu Mammalia) [GO:0010003] 1 organism, 1 sequence
heart development [GO:0007507] 1 organism, 1 sequence
hemopoiesis [GO:0030097] 1 organism, 1 sequence
lung development [GO:0030324] 1 organism, 1 sequence
patterning of blood vessels [GO:0001569] 1 organism, 1 sequence
proximal/distal pattern formation [GO:0009954] 1 organism, 1 sequence
regulation of cell differentiation [GO:0045595] 1 organism, 1 sequence
regulation of cell proliferation [GO:0042127] 1 organism, 1 sequence
regulation of osteoblast differentiation [GO:0045667] 1 organism, 1
sequence
regulation of transcription [GO:0045449] 1 organism, 1 sequence
regulation of transcription, DNA-dependent [GO:0006355] 1 organism, 1
sequence
synapse organization and biogenesis [GO:0050808] 1 organism, 1
sequence
synaptic transmission [GO:0007268] 1 organism, 1 sequence
synaptic vesicle transport [GO:0048489] 1 organism, 1 sequence
Cellular Component adherens junction [GO:0005912] 1 organism, 1
sequence
apical part of cell [GO:0045177] 1 organism, 1 sequence
basolateral plasma membrane [GO:0016323] 1 organism, 1 sequence
cell-cell adherens junction [GO:0005913] 1 organism, 1 sequence
cytoplasm [GO:0005737] 1 organism, 1 sequence
intercellular junction [GO:0005911] 1 organism, 1 sequence
lamellipodium [GO:0030027] 1 organism, 1 sequence
lateral plasma membrane [GO:0016328] 1 organism, 1 sequence
membrane [GO:0016020] 1 organism, 1 sequence
membrane fraction [GO:0005624] 1 organism, 1 sequence
nucleus [GO:0005634] 1 organism, 1 sequence
transcription factor complex [GO:0005667] 1 organism, 1 sequence
Gene Name cGMP-inhibited LOW K(M) cAMP phosphodiesterase PEAK 37, CGI-PDE
Synonyms None
Molecular Function cAMP-specific phosphodiesterase activity
[GO:0004115] 1 organism, 1 sequence
Biological Process signal transduction [GO:0007165] 1 organism, 1
sequence
Cellular Component cytosol [GO:0005829]
Gene Name cGMP-inhibited LOW K(M) cAMP phosphodiesterase PEAK 43, CGI-PDE
Synonyms None.
Molecular Function cAMP-specific phosphodiesterase activity
[GO:0004115] 1 organism, 1 sequence
Biological Process signal transduction [GO:0007165] 1 organism, 1
sequence
Cellular Component cytosol [GO:0005829] 1 organism, 1 sequence
Gene Name CYP19A1
Synonyms ARO1
AROM
AROMATASE
BRAIN AROMATASE
CYAR
CYP19
CYP19A1 PROTEIN
CYPXIX
CYPXIXA1
CYTOCHROME P450 19 TYPE 1
CYTOCHROME P450 19 TYPE I
CYTOCHROME P450 19A1
CYTOCHROME P450, FAMILY 19
ESTROGEN SYNTHETASE
OVARIAN AROMATASE
P-450AROM
P450 17-ALPHA
Molecular Function aromatase activity [GO:0008402] 1 organism, 1
sequence
electron transporter activity [GO:0005489] 1 organism, 1 sequence
monooxygenase activity [GO:0004497] 20 organisms, 22 sequences
oxidoreductase activity [GO:0016491] 20 organisms, 20 sequences
oxygen binding [GO:0019825] 1 organism, 1 sequence
unspecific monooxygenase activity [GO:0050381] 19 organisms, 19
sequences
Biological Process electron transport [GO:0006118] 21 organisms, 23
sequences
steroid biosynthesis [GO:0006694] 1 organism, 1 sequence
transport [GO:0006810] 19 organisms, 19 sequences
Cellular Component extracellular space [GO:0005615] 1 organism, 1
sequence
membrane [GO:0016020] 19 organisms, 19 sequences
membrane fraction [GO:0005624] 1 organism, 1 sequence
microsome [GO:0005792] 1 organism, 1 sequence
Gene Name CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide
2)
Synonyms ARYL HYDROCARBON HYDROXYLASE
CP12
CYP1A-2
CYPIA2
CYTOCHROME P-450 FORM 1-RELATED PROTEIN
CYTOCHROME P-450 FORM 4
CYTOCHROME P450 SUBFAMILY I POLYPEPTIDE 2
CYTOCHROME P450, 1A2
CYTOCHROME P450-1A2
CYTOCHROME P450-D2
DAH2
DIOXIN-INDUCIBLE P3-450
FLAVOPROTEIN-LINKED MONOOXYGENASE
HEPATIC CYTOCHROME P-450MC1
MICROSOMAL MONOOXYGENASE
P(3)450
P-448
P-450 ISOZYME 4
P3-450
P450 4
P450 FORM 4
P450 LM4
P450(PA)
P450-D
P450-MC4
P450-P2/P450-P3
P450-P3
P450-PM4
P4501A2
PULMONARY CYTOCHROME P-450MC1
XENOBIOTIC MONOOXYGENASE
Molecular Function DNA binding [GO:0003677] 1 organism, 1 sequence
binding [GO:0005488] 1 organism, 1 sequence
electron transporter activity [GO:0005489] 1 organism, 1 sequence
heme binding [GO:0020037] 1 organism, 1 sequence
monooxygenase activity [GO:0004497] 14 organisms, 19 sequences
oxidoreductase activity [GO:0016491] 14 organisms, 16 sequences
oxidoreductase activity, acting on paired donors, with incorporation
or reduction of molecular oxygen, reduced flavin or flavoprotein as
one donor, and incorporation of one atom of oxygen [GO:0016712] 12
organisms, 17 sequences
oxygen binding [GO:0019825] 1 organism, 1 sequence
transcription factor activity [GO:0003700] 1 organism, 1 sequence
unspecific monooxygenase activity [GO:0050381] 8 organisms, 9
sequences
Biological Process electron transport [GO:0006118] 15 organisms, 21
sequences
oxygen transport [GO:0015671] 1 organism, 1 sequence
regulation of transcription [GO:0045449] 1 organism, 1 sequence
transport [GO:0006810] 8 organisms, 8 sequences
xenobiotic metabolism [GO:0006805] 1 organism, 1 sequence
Cellular Component RNA polymerase complex [GO:0030880] 1 organism, 1
sequence
endoplasmic reticulum [GO:0005783] 8 organisms, 8 sequences
extracellular space [GO:0005615] 1 organism, 1 sequence
membrane [GO:0016020] 8 organisms, 8 sequences
microsome [GO:0005792] 8 organisms, 8 sequences
nucleus [GO:0005634] 1 organism, 1 sequence
Gene Name CYP3A4
Synonyms CYPIIIA4
CYTOCHROME P450
CYTOCHROME P450 3A4
CYTOCHROME P450, SUBFAMILY IIIA, POLYPEPTIDE 4
NF-25
NIFEDIPINE OXIDASE
P450-PCN1
QUININE 3-MONOOXYGENASE
Molecular Function monooxygenase activity [GO:0004497] 2 organisms, 3
sequences
oxidoreductase activity [GO:0016491] 1 organism, 2 sequences
oxidoreductase activity, acting on paired donors, with incorporation
or reduction of molecular oxygen, reduced flavin or flavoprotein as
one donor, and incorporation of one atom of oxygen [GO:0016712] 1
organism, 2 sequences
oxygen binding [GO:0019825] 1 organism, 1 sequence
quinine 3-monooxygenase activity [GO:0050591] 1 organism, 1 sequence
Biological Process electron transport [GO:0006118] 2 organisms, 3
sequences
lipid metabolism [GO:0006629] 1 organism, 1 sequence
transport [GO:0006810] 1 organism, 1 sequence
xenobiotic metabolism [GO:0006805] 1 organism, 1 sequence
Cellular Component endoplasmic reticulum [GO:0005783] 1 organism, 1
sequence
membrane [GO:0016020] 1 organism, 1 sequence
membrane fraction [GO:0005624] 1 organism, 1 sequence
microsome [GO:0005792] 1 organism, 1 sequence
Gene Name CYP3A5
Synonyms CYPIIIA5
CYTOCHROME P-450
CYTOCHROME P450
CYTOCHROME P450 3A5
CYTOCHROME P450, FAMILY 3, SUBFAMILY A, POLYPEPTIDE 5
HLP2
P450-PCN3
Molecular Function monooxygenase activity [GO:0004497] 1 organism, 3
sequences
oxidoreductase activity [GO:0016491] 1 organism, 3 sequences
oxidoreductase activity, acting on paired donors, with incorporation
or reduction of molecular oxygen, reduced flavin or flavoprotein as
one donor, and incorporation of one atom of oxygen [GO:0016712] 1
organism, 2 sequences
oxygen binding [GO:0019825] 1 organism, 1 sequence
unspecific monooxygenase activity [GO:0050381] 1 organism, 1 sequence
Biological Process electron transport [GO:0006118] 1 organism, 4
sequences
steroid metabolism [GO:0008202] 1 organism, 1 sequence
transport [GO:0006810] 1 organism, 1 sequence
xenobiotic metabolism [GO:0006805] 1 organism, 1 sequence
Cellular Component endoplasmic reticulum [GO:0005783] 1 organism, 1
sequence
membrane [GO:0016020] 1 organism, 1 sequence
membrane fraction [GO:0005624] 1 organism, 1 sequence
microsome [GO:0005792] 1 organism, 1 sequence
Gene Name GnRH receptor
Synonym GONADOTROPIN-RELEASING HORMONE RECEPTOR
Molecular Function G-protein coupled receptor activity [GO:0004930] 2
organisms, 2 sequences
gonadotropin-releasing hormone receptor activity [GO:0004968] 2
organisms, 2 sequences
receptor activity [GO:0004872] 2 organisms, 2 sequences
rhodopsin-like receptor activity [GO:0001584] 2 organisms, 2 sequences
Biological Process G-protein coupled receptor protein signaling
pathway [GO:0007186] 2 organisms, 2 sequences
Cellular Component integral to membrane [GO:0016021] 2 organisms, 2
sequences
Gene Name GNRHR
Synonyms GNRH RECEPTOR
GNRH-R
GONADOTROPHIN RELEASING HORMONE RECEPTOR
GONADOTROPIN-RELEASING HORMONE RECEPTOR
LHRH
LUTEINIZING HORMONE-RELEASING HORMONE RECEPTOR
Molecular Function G-protein coupled receptor activity [GO:0004930] 13
organisms, 15 sequences
gonadotropin-releasing hormone receptor activity [GO:0004968] 12
organisms, 14 sequences
growth hormone-releasing hormone receptor activity [GO:0016520] 1
organism, 1 sequence
molecular_function unknown [GO:0005554] 1 organism, 1 sequence
receptor activity [GO:0004872] 14 organisms, 16 sequences
rhodopsin-like receptor activity [GO:0001584] 13 organisms, 15
sequences
signal transducer activity [GO:0004871] 11 organisms, 11 sequences
Biological Process G-protein coupled receptor protein signaling
pathway [GO:0007186] 13 organisms, 15 sequences
biological_process unknown [GO:0000004] 1 organism, 1 sequence
development [GO:0007275] 1 organism, 1 sequence
signal transduction [GO:0007165] 11 organisms, 11 sequences
Cellular Component integral to membrane [GO:0016021] 13 organisms, 15
sequences
membrane [GO:0016020] 1 organism, 1 sequence
plasma membrane [GO:0005886] 1 organism, 1 sequence
Gene Name GRIN1
Synonyms GLURZ1
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR
GRIN1 PROTEIN
MUS MUSCULUS 16 DAYS NEONATE CEREBELLUM CDNA, RIKEN FULL-LENGTH
ENRICHED LIBRARY, CLONE:9630045H24 PRODUCT:GLUTAMATE RECEPTOR,
IONOTROPIC, NMDA1 (ZETA 1), FULL INSERT SEQUENCE
N-METHYL-D-ASPARTATE RECEPTOR
N-METHYL-D-ASPARTATE RECEPTOR 1
N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT NR1
NMD-R1
NMDA RECEPTOR 1 ISOFORM NR1-1 PRECURSOR
NMDAR1
Molecular Function N-methyl-D-aspartate selective glutamate receptor
activity [GO:0004972] 3 organisms, 4 sequences
glutamate binding [GO:0016595] 3 organisms, 4 sequences
glutamate-gated ion channel activity [GO:0005234] 4 organisms, 7
sequences
glycine binding [GO:0016594] 3 organisms, 4 sequences
glycine-gated ion channel activity [GO:0016933] 3 organisms, 4
sequences
ion channel activity [GO:0005216] 4 organisms, 7 sequences
ionotropic glutamate receptor activity [GO:0004970] 4 organisms, 7
sequences
magnesium ion binding [GO:0000287] 3 organisms, 3 sequences
metabotropic glutamate, GABA-B-like receptor activity [GO:0008067] 1
organism, 1 sequence
motor activity [GO:0003774] 3 organisms, 4 sequences
potassium channel activity [GO:0005267] 4 organisms, 7 sequences
protein binding [GO:0005515] 1 organism, 3 sequences
receptor activity [GO:0004872] 4 organisms, 8 sequences
receptor binding [GO:0005102] 1 organism, 3 sequences
transporter activity [GO:0005215] 4 organisms, 7 sequences
Biological Process calcium ion homeostasis [GO:0006874] 3 organisms, 4
sequences
cation transport [GO:0006812] 3 organisms, 4 sequences
glutamate signaling pathway [GO:0007215] 3 organisms, 4 sequences
ion transport [GO:0006811] 4 organisms, 7 sequences
learning and/or memory [GO:0007611] 3 organisms, 4 sequences
potassium ion transport [GO:0006813] 4 organisms, 7 sequences
regulation of synaptic plasticity [GO:0048167] 3 organisms, 4
sequences
response to ethanol [GO:0045471] 3 organisms, 3 sequences
synaptic transmission [GO:0007268] 4 organisms, 8 sequences
transport [GO:0006810] 4 organisms, 7 sequences
Cellular Component N-methyl-D-aspartate selective glutamate receptor
complex [GO:0017146] 3 organisms, 4 sequences
cytoplasm [GO:0005737] 1 organism, 3 sequences
dendrite [GO:0030425] 3 organisms, 4 sequences
extracellular space [GO:0005615] 1 organism, 3 sequences
growth cone [GO:0030426] 3 organisms, 3 sequences
integral to membrane [GO:0016021] 4 organisms, 8 sequences
membrane [GO:0016020] 4 organisms, 8 sequences
membrane fraction [GO:0005624] 1 organism, 3 sequences
postsynaptic membrane [GO:0045211] 1 organism, 3 sequences
synaptic vesicle [GO:0008021] 1 organism, 3 sequences
Gene Name LEP
Synonyms LEPTIN
LEPTIN PRECURSOR
LEPTIN,
OB
OBESE PROTEIN
OBESITY FACTOR
OBS
Molecular Function cytokine activity [GO:0005125] 1 organism, 1
sequence
growth factor activity [GO:0008083] 1 organism, 1 sequence
hormone activity [GO:0005179] 20 organisms, 22 sequences
protein binding [GO:0005515] 1 organism, 1 sequence
Biological Process JAK-STAT cascade [GO:0007259] 1 organism, 1
sequence
bile acid metabolism [GO:0008206] 1 organism, 1 sequence
cAMP-mediated signaling [GO:0019933] 1 organism, 1 sequence
cell-cell signaling [GO:0007267] 1 organism, 1 sequence
energy reserve metabolism [GO:0006112] 2 organisms, 2 sequences
fatty acid catabolism [GO:0009062] 1 organism, 1 sequence
glucose metabolism [GO:0006006] 1 organism, 1 sequence
intracellular signaling cascade [GO:0007242] 1 organism, 1 sequence
lipid metabolism [GO:0006629] 1 organism, 1 sequence
negative regulation of metabolism [GO:0009892] 1 organism, 1 sequence
positive regulation of myeloid blood cell differentiation [GO:0045639]
1 organism, 1 sequence
regulation of cholesterol absorption [GO:0030300] 1 organism, 1
sequence
regulation of metabolism [GO:0019222] 1 organism, 1 sequence
signal transduction [GO:0007165] 20 organisms, 22 sequences
Cellular Component extracellular region [GO:0005576] 20 organisms, 22
sequences
extracellular space [GO:0005615] 2 organisms, 2 sequences
Gene Name Mt1
Synonyms LPMT1
MELATONIN RECEPTOR
METALLOTHIONEIN
METALLOTHIONEIN 1
METALLOTHIONEIN I
METALLOTHIONEIN-I
MT
MT-I
MT1 MELATONIN RECEPTOR
MT1 PROTEIN
MYOTOXIN
PHOSPHOLIPASE A2 HOMOLOG PRECURSOR
Molecular Function G-protein coupled receptor activity [GO:0004930] 2
organisms, 2 sequences
calcium ion binding [GO:0005509] 1 organism, 1 sequence
copper ion binding [GO:0005507] 1 organism, 2 sequences
melatonin receptor activity [GO:0008502] 2 organisms, 2 sequences
metal ion binding [GO:0046872] 7 organisms, 8 sequences
phospholipase A2 activity [GO:0004623] 1 organism, 1 sequence
receptor activity [GO:0004872] 2 organisms, 2 sequences
rhodopsin-like receptor activity [GO:0001584] 2 organisms, 2 sequences
zinc ion binding [GO:0008270] 1 organism, 2 sequences
Biological Process G-protein coupled receptor protein signaling
pathway [GO:0007186] 2 organisms, 2 sequences
lipid catabolism [GO:0016042] 1 organism, 1 sequence
metal ion homeostasis [GO:0006875] 1 organism, 2 sequences
nitric oxide mediated signal transduction [GO:0007263] 1 organism, 2
sequences
pathogenesis [GO:0009405] 1 organism, 1 sequence
zinc ion homeostasis [GO:0006882] 1 organism, 2 sequences
Cellular Component cytosol [GO:0005829] 1 organism, 2 sequences
integral to membrane [GO:0016021] 2 organisms, 2 sequences
lysosome [GO:0005764] 1 organism, 2 sequences
Gene Name Mt2
Synonyms CG10692-PA, ISOFORM A
CG10692-PB, ISOFORM B
DNA (5-CYTOSINE) METHYLTRANSFERASE HOMOLOG
DNMT2
GM14972P
METALLOTHIONEIN
METALLOTHIONEIN 2
METALLOTHIONEIN II
METALLOTHIONEIN-II
MT
MT 2
MT-II
MT2A
Molecular Function DNA (cytosine-5-)-methyltransferase activity
[GO:0003886] 1 organism, 4 sequences
DNA binding [GO:0003677] 1 organism, 4 sequences
metal ion binding [GO:0046872] 10 organisms, 10 sequences
methyltransferase activity [GO:0008168] 1 organism, 1 sequence
transferase activity [GO:0016740] 1 organism, 1 sequence
zinc ion binding [GO:0008270] 1 organism, 1 sequence
Biological Process DNA methylation [GO:0006306] 1 organism, 4
sequences
DNA methylation during embryonic development [GO:0043045] 1 organism,
4 sequences
nitric oxide mediated signal transduction [GO:0007263] 1 organism, 1
sequence
response to metal ion [GO:0010038] 1 organism, 1 sequence
zinc ion homeostasis [GO:0006882] 1 organism, 1 sequence
Cellular Component nucleus [GO:0005634] 1 organism, 1 sequence
Gene Name MT2A
Synonyms CES1
METALLOPROTEINASE MT2A
METALLOTHIONEIN 2A
METALLOTHIONEIN-II
METALLOTHIONEIN-IIA
MT-II
MT-IIA
MT2
Molecular Function copper ion binding [GO:0005507] 1 organism, 1
sequence
metal ion binding [GO:0046872] 4 organisms, 4 sequences
Biological Process copper ion homeostasis [GO:0006878] 1 organism, 1
sequence
Gene Name MT3
Synonyms GIF
GIFB
GROWTH INHIBITORY FACTOR
METALLOTHIONEIN
METALLOTHIONEIN 3
METALLOTHIONEIN-III
MT-III
Molecular Function antioxidant activity [GO:0016209] 6 organisms, 6
sequences
copper ion binding [GO:0005507] 6 organisms, 6 sequences
metal ion binding [GO:0046872] 7 organisms, 7 sequences
zinc ion binding [GO:0008270] 6 organisms, 6 sequences
Biological Process cell proliferation [GO:0008283] 1 organism, 1
sequence
metal ion homeostasis [GO:0006875] 6 organisms, 6 sequences
negative regulation of cell growth [GO:0030308] 6 organisms, 6
sequences
negative regulation of dendrite morphogenesis [GO:0050774] 6
organisms, 6 sequences
negative regulation of neurogenesis [GO:0050768] 6 organisms, 6
sequences
removal of superoxide radicals [GO:0019430] 6 organisms, 6 sequences
response to hypoxia [GO:0001666] 6 organisms, 6 sequences
Cellular Component synaptic vesicle [GO:0008021] 6 organisms, 6
sequences
Gene Name PDE3B
Synonyms CGI-PDE B
CGIP1
CGIPDE1
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B
CGMP-INHIBITED CAMP PHOPHODIESTERASE
CYCLIC GMP INHIBITED PHOSPHODIESTERASE B
PHOSPHODIESTERASE 3B
PHOSPHODIESTERASE 3B, CGMP-INHIBITED
Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity
[GO:0004114] 3 organisms, 6 sequences
cAMP-specific phosphodiesterase activity [GO:0004115] 1 organism, 1
sequence
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
[GO:0004119] 1 organism, 1 sequence
catalytic activity [GO:0003824] 3 organisms, 6 sequences
hydrolase activity [GO:0016787] 3 organisms, 5 sequences
Biological Process signal transduction [GO:0007165] 3 organisms, 6
sequences
Cellular Component membrane [GO:0016020] 3 organisms, 3 sequences
Gene Name PDE4A
Synonyms CAMP SPECIFIC PHOSPHODIESTERASE VARIANT PDE4A-10
CAMP SPECIFIC PHOSPHODIESTERASE VARIANT TM3
CAMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE 4A
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A
CAMP-SPECIFIC PHOSPHODIESTERASE
CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE FCPDE4A1A
CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10
CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE OCPDE4A1A
CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE SSPDE4A1A
DPDE2
PDE46
PDE4A PROTEIN
PHOSPHODIESTERASE 4A, CAMP-SPECIFIC
PHOSPHODIESTERASE 4A, CAMP-SPECIFIC (PHOSPHODIESTERASE E2 DUNCE
HOMOLOG, DROSOPHILA)
PHOSPHODIESTERASE E2 DUNCE HOMOLOG, DROSOPHILA
Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity
[GO:0004114] 5 organisms, 8 sequences
cAMP-specific phosphodiesterase activity [GO:0004115] 1 organism, 1
sequence
catalytic activity [GO:0003824] 4 organisms, 7 sequences
hydrolase activity [GO:0016787] 4 organisms, 6 sequences
Biological Process signal transduction [GO:0007165] 4 organisms, 7
sequences
Cellular Component insoluble fraction [GO:0005626] 1 organism, 1
sequence
membrane fraction [GO:0005624] 1 organism, 1 sequence
soluble fraction [GO:0005625] 1 organism, 1 sequence
Gene Name PDE4B
Synonyms CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B
CAMP-SPECIFIC PHOSPHODIESTERASE
CAMP-SPECIFIC PHOSPHODIESTERASE ISOFORM PDE4B1
CAMP-SPECIFIC PHOSPHODIESTERASE ISOFORM PDE4B4
DPDE4
MUS MUSCULUS 10 DAYS EMBRYO WHOLE BODY CDNA, RIKEN FULL-LENGTH
ENRICHED LIBRARY, CLONE:2610306O03 PRODUCT:PHOSPHODIESTERASE 4B, CAMP
SPECIFIC, FULL INSERT SEQUENCE
PDE32
PDE4B PROTEIN
PHOSPHODIESTERASE 4B
PHOSPHODIESTERASE 4B, CAMP SPECIFIC
PHOSPHODIESTERASE 4B, CAMP-SPECIFIC
PHOSPHODIESTERASE 4B, CAMP-SPECIFIC (PHOSPHODIESTERASE E4 DUNCE
HOMOLOG, DROSOPHILA)
PHOSPHODIESTERASE E4 DUNCE HOMOLOG, DROSOPHILA
Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity
[GO:0004114] 3 organisms, 10 sequences
cAMP-specific phosphodiesterase activity [GO:0004115] 1 organism, 1
sequence
calmodulin binding [GO:0005516] 1 organism, 2 sequences
catalytic activity [GO:0003824] 3 organisms, 9 sequences
hydrolase activity [GO:0016787] 3 organisms, 7 sequences
Biological Process signal transduction [GO:0007165] 3 organisms, 10
sequences
NOT smooth muscle contraction [GO:0006939] 1 organism, 5 sequences
Cellular Component insoluble fraction [GO:0005626] 1 organism, 1
sequence
soluble fraction [GO:0005625] 1 organism, 1 sequence
Gene Name PDE4D
Synonyms CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D
CAMP-SPECIFIC PHOSPHODIESTERASE 4D
DPDE3
PDE43
Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity
[GO:0004114] 3 organisms, 3 sequences
cAMP-specific phosphodiesterase activity [GO:0004115] 1 organism, 1
sequence
catalytic activity [GO:0003824] 1 organism, 1 sequence
cyclic-nucleotide phosphodiesterase activity [GO:0004112] 1 organism,
1 sequence
hydrolase activity [GO:0016787] 3 organisms, 3 sequences
Biological Process cAMP catabolism [GO:0006198] 1 organism, 1 sequence
cyclic nucleotide metabolism [GO:0009187] 1 organism, 1 sequence
regulation of G-protein coupled receptor protein signaling pathway
[GO:0008277] 1 organism, 1 sequence
signal transduction [GO:0007165] 3 organisms, 3 sequences
smooth muscle contraction [GO:0006939] 1 organism, 1 sequence
Cellular Component cellular_component unknown [GO:0008372] 1 organism,
1 sequence
insoluble fraction [GO:0005626] 1 organism, 1 sequence
soluble fraction [GO:0005625] 1 organism, 1 sequence
Gene Name PDYN
Synonyms BETA-NEOENDORPHIN-DYNORPHIN PRECURSOR
BETA-NEOENDORPHIN-DYNORPHIN PREPROPROTEIN
PREPRODYNORPHIN
PRODYNORPHIN PRECURSOR
PROENKEPHALIN B
Molecular Function opioid peptide activity [GO:0001515] 6 organisms, 6
sequences
Biological Process neuropeptide signaling pathway [GO:0007218] 7
organisms, 8 sequences
regulation of neurotransmitter secretion [GO:0046928] 1 organism, 1
sequence
synaptic transmission [GO:0007268] 6 organisms, 6 sequences
Cellular Component extracellular space [GO:0005615] 1 organism, 2
sequences
plasma membrane [GO:0005886] 1 organism, 1 sequence
Gene Name PIK3C3
Synonyms CLASS 3 PHOSPHOINOSITIDE-3-KINASE
PHOSPHATIDYLINOSITOL 3-KINASE
PHOSPHOINOSITIDE-3-KINASE CLASS 3
PHOSPHOINOSITIDE-3-KINASE, CLASS 3
PIK3C3 PROTEIN
VPS34
Molecular Function inositol or phosphatidylinositol kinase activity
[GO:0004428] 5 organisms, 7 sequences
kinase activity [GO:0016301] 5 organisms, 6 sequences
phosphatidylinositol 3-kinase activity [GO:0016303] 4 organisms, 6
sequences
phosphotransferase activity, alcohol group as acceptor [GO:0016773] 4
organisms, 6 sequences
Cellular Component phosphoinositide 3-kinase complex [GO:0005942] 4
organisms, 6 sequences
Gene Name RAD17
Synonyms CELL CYCLE CHECKPOINT PROTEIN RAD17
CG7825-PA
DNA REPAIR PROTEIN RAD17
HRAD17
R24L
RAD17 HOMOLOG ISOFORM 3
RAD17 PROTEIN
RE31829P
RF-C/ACTIVATOR 1 HOMOLOG
RFC-LIKE DNA CHECKPOINT PROTEIN RAD17
Molecular Function ATP binding [GO:0005524] 6 organisms, 7 sequences
DNA binding [GO:0003677] 7 organisms, 11 sequences
nucleoside-triphosphatase activity [GO:0017111] 2 organisms, 3
sequences
nucleotide binding [GO:0000166] 2 organisms, 3 sequences
Biological Process DNA repair [GO:0006281] 7 organisms, 11 sequences
DNA replication [GO:0006260] 7 organisms, 11 sequences
cell cycle [GO:0007049] 7 organisms, 11 sequences
development [GO:0007275] 1 organism, 1 sequence
response to DNA damage stimulus [GO:0006974] 6 organisms, 7 sequences
Cellular Component DNA replication factor C complex [GO:0005663] 7
organisms, 11 sequences
nucleus [GO:0005634] 7 organisms, 11 sequences
Gene Name SLC30A4
Synonyms DRI 27 PROTEIN
LETHAL MILK PROTEIN
LM
SOLUTE CARRIER FAMILY 30 (ZINC TRANSPORTER), MEMBER 4
SOLUTE CARRIER FAMILY 30, MEMBER 4
ZINC TRANSPORTER 4
ZNT-4
ZNT4
Molecular Function cation transporter activity [GO:0008324] 3
organisms, 4 sequences
zinc ion transporter activity [GO:0005385] 2 organisms, 2 sequences
Biological Process cation transport [GO:0006812] 3 organisms, 4
sequences
transport [GO:0006810] 4 organisms, 4 sequences
zinc ion transport [GO:0006829] 4 organisms, 4 sequences
Cellular Component cytoplasmic vesicle [GO:0016023] 1 organism, 1
sequence
endosome [GO:0005768] 1 organism, 1 sequence
integral to membrane [GO:0016021] 4 organisms, 4 sequences
lysosome [GO:0005764] 1 organism, 1 sequence
membrane [GO:0016020] 3 organisms, 4 sequences
synaptic vesicle [GO:0008021] 1 organism, 1 sequence
Gene Name TP53
Synonyms ANTIGEN NY-CO-13
CELLULAR TUMOR ANTIGEN P53
DRP53
P53
PHOSPHOPROTEIN P53
TP53 PROTEIN
TRP53
TUMOR PROTEIN P53
TUMOR SUPPRESSOR P53
Molecular Function ATP binding [GO:0005524] 19 organisms, 19 sequences
DNA binding [GO:0003677] 34 organisms, 37 sequences
DNA strand annealing activity [GO:0000739] 19 organisms, 19 sequences
RNA polymerase II transcription factor activity [GO:0003702] 1
organism, 1 sequence
copper ion binding [GO:0005507] 19 organisms, 19 sequences
nuclease activity [GO:0004518] 1 organism, 1 sequence
protein binding [GO:0005515] 19 organisms, 19 sequences
protein heterodimerization activity [GO:0046982] 1 organism, 1
sequence
transcription factor activity [GO:0003700] 34 organisms, 37 sequences
zinc ion binding [GO:0008270] 1 organism, 1 sequence
Biological Process DNA damage response, signal transduction by p53
class mediator [GO:0030330] 1 organism, 1 sequence
DNA damage response, signal transduction by p53 class mediator
resulting in induction of apoptosis [GO:0042771] 1 organism, 1
sequence
DNA damage response, signal transduction resulting in induction of
apoptosis [GO:0008630] 1 organism, 1 sequence
DNA recombination [GO:0006310] 1 organism, 1 sequence
DNA repair [GO:0006281] 1 organism, 1 sequence
apoptosis [GO:0006915] 34 organisms, 36 sequences
base-excision repair [GO:0006284] 19 organisms, 19 sequences
caspase activation via cytochrome c [GO:0008635] 19 organisms, 19
sequences
cell aging [GO:0007569] 19 organisms, 19 sequences
cell cycle [GO:0007049] 34 organisms, 35 sequences
cell cycle arrest [GO:0007050] 19 organisms, 19 sequences
cell cycle checkpoint [GO:0000075] 1 organism, 1 sequence
cell differentiation [GO:0030154] 19 organisms, 19 sequences
cell proliferation [GO:0008283] 19 organisms, 19 sequences
development [GO:0007275] 19 organisms, 19 sequences
induction of apoptosis by hormones [GO:0008628] 1 organism, 1 sequence
negative regulation of DNA replication [GO:0008156] 1 organism, 1
sequence
negative regulation of apoptosis [GO:0043066] 1 organism, 1 sequence
negative regulation of cell cycle [GO:0045786] 34 organisms, 35
sequences
negative regulation of cell growth [GO:0030308] 19 organisms, 19
sequences
negative regulation of fibroblast proliferation [GO:0048147] 1
organism, 1 sequence
negative regulation of helicase activity [GO:0051097] 1 organism, 1
sequence
nucleotide-excision repair [GO:0006289] 19 organisms, 19 sequences
protein tetramerization [GO:0051262] 1 organism, 1 sequence
protein-nucleus import, translocation [GO:0000060] 1 organism, 1
sequence
regulation of cell cycle [GO:0000074] 1 organism, 1 sequence
regulation of cell proliferation [GO:0042127] 1 organism, 1 sequence
regulation of mitochondrial membrane permeability [GO:0046902] 1
organism, 1 sequence
regulation of transcription from RNA polymerase II promoter
[GO:0006357] 1 organism, 1 sequence
regulation of transcription, DNA-dependent [GO:0006355] 34 organisms,
37 sequences
response to DNA damage stimulus [GO:0006974] 2 organisms, 2 sequences
response to UV [GO:0009411] 1 organism, 1 sequence
response to X-ray [GO:0010165] 1 organism, 1 sequence
transcription [GO:0006350] 34 organisms, 35 sequences
Cellular Component cytoplasm [GO:0005737] 19 organisms, 19 sequences
cytosol [GO:0005829] 1 organism, 1 sequence
mitochondrion [GO:0005739] 19 organisms, 19 sequences
nucleolus [GO:0005730] 19 organisms, 19 sequences
nucleus [GO:0005634] 34 organisms, 37 sequences
Gene Name UGT1A1
Synonyms BILIRUBIN SPECIFIC UDPGT ISOZYME 1
BILIRUBIN UDP-GLUCRONOSYLTRASFERASE 1-1
GNT1
HUG-BR1
UDP GLYCOSYLTRANSFERASE 1 FAMILY POLYPEPTIDE A1
UDP GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1 PRECURSOR
UDP-GLUCURONOSYLTRANSFERASE
UDP-GLUCURONOSYLTRANSFERASE 1-1 PRECURSOR, MICROSOMAL
UDP-GLUCURONOSYLTRANSFERASE 1A1
UDPGT
UGT-1A
UGT1
UGT1*1
UGT1-01
UGT1.1
UGT1A
UGTBR1
UGTP4
Molecular Function glucuronosyltransferase activity [GO:0015020] 2
organisms, 2 sequences
transferase activity [GO:0016740] 13 organisms, 16 sequences
transferase activity, transferring glycosyl groups [GO:0016757] 3
organisms, 3 sequences
transferase activity, transferring hexosyl groups [GO:0016758] 4
organisms, 7 sequences
Biological Process bilirubin conjugation [GO:0006789] 1 organism, 1
sequence
digestion [GO:0007586] 1 organism, 1 sequence
estrogen metabolism [GO:0008210] 1 organism, 1 sequence
metabolism [GO:0008152] 4 organisms, 7 sequences
Cellular Component endoplasmic reticulum [GO:0005783] 2 organisms, 2
sequences
integral to membrane [GO:0016021] 4 organisms, 6 sequences
integral to plasma membrane [GO:0005887] 1 organism, 2 sequences
microsome [GO:0005792] 4 organisms, 6 sequences
Gene Name WRN
Synonyms HOMOLOG OF HUMAN WERNERS SYNDROME PROTEIN
RECQ3
RECQL2
WERNER SYNDROME HELICASE
WERNER SYNDROME HELICASE HOMOLOG
WERNER SYNDROME PROTEIN
WRN PROTEIN
Molecular Function 3'-5' exonuclease activity [GO:0008408] 2
organisms, 4 sequences
ATP binding [GO:0005524] 2 organisms, 4 sequences
ATP-dependent helicase activity [GO:0008026] 2 organisms, 4 sequences
DNA binding [GO:0003677] 2 organisms, 2 sequences
DNA helicase activity [GO:0003678] 1 organism, 1 sequence
helicase activity [GO:0004386] 2 organisms, 4 sequences
hydrolase activity [GO:0016787] 2 organisms, 3 sequences
nucleic acid binding [GO:0003676] 2 organisms, 4 sequences
Biological Process DNA metabolism [GO:0006259] 2 organisms, 4
sequences
aging [GO:0007568] 1 organism, 1 sequence
regulation of growth rate [GO:0040009] 1 organism, 3 sequences
telomere maintenance [GO:0000723] 1 organism, 3 sequences
Cellular Component intracellular [GO:0005622] 2 organisms, 4 sequences
nucleus [GO:0005634] 2 organisms, 2 sequences
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