CAUSATION ARCHIVES

In vitro effects of fluoroquinolone and aminoglycoside antibiotics on human keratocytes. Leonardi A, Papa V, Fregona I, Russo P, De Franchis G, Milazzo G. Department of Neuroscience, Ophthalmology Unit, University of Padova, Italy. 

The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926).Kilic B, Kruse M, Stahlmann R. Institute of Clinical Pharmacology and Toxicology, Charite Campus Benjamin Franklin, Garystr. 5, 14195 Berlin, Germany. 

Microsomal metabolism of ciprofloxacin generates free radicals.

Neurotoxic effects of the fluoroquinolones include insomnia, seizures, delirium, and psychosis.

In vitro method for prediction of the phototoxic potentials of fluoroquinolones.

Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.

Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions.

 Adverse reactions to Flouroquinolones Mechanistic Aspects

Adverse drug reactions to fluoroquinolones at a tertiary care hospital in northern India.

FQ Toxicity & Caffeine

Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro

Fluoroquinolone development from 1985 to the present

Safety of the Fluoroquinolone Antibiotics: Focus on Molecular Structure

Drugs which provoke seizures clinically

Necrosis (cell death) due to toxic insult

The serious side effects and drug-drug interactions caused by antibiotics

Effects of fluoroquinolones on the locomotor activity in rats

Fluoroquinolone toxicity profiles: a review focusing on newer agents

The safety profile of the fluoroquinolones

Retrospective analysis of the safety profile of oral and intravenous ciprofloxacin in a geriatric population

Adverse reactions to fluoroquinolones. an overview on mechanistic aspects

Fluorine level in the bone and cartilage in children treated with ciprofloxacin (data obtained from the femur distal part

Antimicrobial safety and tolerability: differences and dilemmas

Safety of the new fluoroquinolones compared with ciprofloxacin

The P450 enzymes collectively metabolize xenobiotics which include almost all drugs

Selective antagonism of the GABA(A) receptor by ciprofloxacin and biphenylacetic acid

Immunomodulating activity of quinolones: review

Quinolones differ in the number and placement of nitrogen in the 4-quinolone nucleus

Mechanism of Action

Fluoroquinolones should never be used to treat pneumococcal pneumonia

Chloroquine and hydroxychloroquine belong to the quinolone family

Positive umuC results in hospital wastewater are strongly dependent on the presence of fluoroquinolone antibiotics

Nephrotoxicity and Purpura Associated with Levofloxacin

Possible Gatifloxacin-Induced Fulminant Hepatic Failure

Clostridium difficile infection associated with levofloxacin treatment

Characterisation of Ciprofloxacin Binding to the Linear Single and Double
Stranded DNA

From toxic precursors to safe drugs. Mechanisms and relevance of idiosyncratic drug reactions.
Petersen KU.

Understanding delayed adverse drug reactions:

Microsomal metabolism of ciprofloxacin generates free radicals.

Neurotoxic effects of the fluoroquinolones include insomnia, seizures, delirium, and psychosis.

In vitro method for prediction of the phototoxic potentials of fluoroquinolones.

Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation.

Pharmacokinetic aspects of treating infections in the intensive care unit: focus on drug interactions.

 Adverse reactions to Flouroquinolones Mechanistic Aspects

Adverse drug reactions to fluoroquinolones at a tertiary care hospital in northern India.

FQ Toxicity & Caffeine

Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro

Fluoroquinolone development from 1985 to the present

Safety of the Fluoroquinolone Antibiotics: Focus on Molecular Structure

Drugs which provoke seizures clinically

Necrosis (cell death) due to toxic insult

The serious side effects and drug-drug interactions caused by antibiotics

 Effects of fluoroquinolones on the locomotor activity in rats

Fluoroquinolone toxicity profiles: a review focusing on newer agents

The safety profile of the fluoroquinolones

Retrospective analysis of the safety profile of oral and intravenous ciprofloxacin in a geriatric population

Adverse reactions to fluoroquinolones. an overview on mechanistic aspects

Fluorine level in the bone and cartilage in children treated with ciprofloxacin (data obtained from the femur distal part

Antimicrobial safety and tolerability: differences and dilemmas

Safety of the new fluoroquinolones compared with ciprofloxacin

 The P450 enzymes collectively metabolize xenobiotics which include almost all drugs

Selective antagonism of the GABA(A) receptor by ciprofloxacin and biphenylacetic acid

Immunomodulating activity of quinolones: review

Quinolones differ in the number and placement of nitrogen in the 4-quinolone nucleus

Mechanism of Action

Fluoroquinolones should never be used to treat pneumococcal pneumonia

Chloroquine and hydroxychloroquine belong to the quinolone family

 Positive umuC results in hospital wastewater are strongly dependent on the presence of fluoroquinolone antibiotics

Nephrotoxicity and Purpura Associated with Levofloxacin

Possible Gatifloxacin-Induced Fulminant Hepatic Failure

Clostridium difficile infection associated with levofloxacin treatment

Characterisation of Ciprofloxacin Binding to the Linear Single and Double
Stranded DNA