
General pharmacology of the new quinolone
antibacterial agent levofloxacin.
Takasuna K, Kasai Y, Usui C,
Takahashi M, Hirohashi M, Tamura K, Takayama S. Drug Safety
Research Center, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Mechanisms of pefloxacin-induced pain.
Bull Exp Biol Med. 2004 Apr;137(4):336-8. Kukushkin ML, Igonkina SI,
Guskova TA. Laboratory of Pathophysiology of Pain, Institute of
General Pathology and Pathophysiology, Russian Academy of Medical
Sciences, Moscow.
[General pharmacology of T-3761, a new oral quinolone antibacterial
agent (2). Effect on the respiratory and cardiovascular systems,
autonomic nervous system and other functions]
[Article in Japanese] Furuhata K, Hiraiwa T, Terashima N, Arai H, Ono S, Hashiba K,
Maekawa M, Kitamura K, Nakada Y, Mori Y, et al. Research Laboratories, Toyama Chemical Co., Ltd.
Peripheral Neuropathy Associated With Cipro
Peripheral neuropathy associated with
Pefloxacin,
1990, 1995,
Sparfloxacin 1992, Ciprofloxacin 1988, 1990, 1992, 1993, 1994, 1995,
1996, Ofloxacin 1993, Moxifloxacin 2000, 2001, 2002
Peripheral neuropathy associated with Avelox and Tequin 2002
Peripheral sensory disturbances related to treatment with fluoroquinolones.
Treatment Options in Neuropathic Pain
What are the differential diagnoses for peripheral neuropathy?
The Immunology of the Nervous System
Lamarine (1994) notes caffeine is able to penetrate the blood brain barrier and directly
Neural Plasticity and CNS Injury
British Inflammation Research Association (BIRAs).
Inflammation in the CNS and its Contribution to Neurological Disease
The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown
Neural-immune interactions in health and disease
Peripheral neuropathy associated with fluoroquinolones
What are the differential diagnoses for peripheral neuropathy?
Inflammation in the CNS and its Contribution to Neurological Disease
Update on Drugs that May Cause or Exacerbate Myasthenia Gravis
CNS adverse effects are known to occur relatively commonly with some fluoroquinolones
Neurochemical studies on quinolone antibiotics: effects on glutamate,
GABA and adenosine systems in mammalian CNS.
Potential neurologic toxicity related to ciprofloxacin
Quinolone toxicity: methods of assessment.
The following citations have no abstract. The full text can be purchased from the links provide or by contacting the author or the publication cited:
Arch Intern Med. 2001 Oct 8;161(18):2261-2.
Myoclonus and generalized seizures associated with gatifloxacin
treatment.
Marinella MA.
Dayton, Ohio.
http://archinte.ama-assn.org/cgi/content/full/161/18/2261
Additional Research from PubMed/Medline
Psychiatric (25)
Possible gatifloxacin-induced seizure.
2
Skretkowicz J, Gondko A.[Fluoroquinolones interactions with
nonsteroidal anti-inflammatory drugs]
Pol Merkuriusz Lek. 2004 Feb;16(92):194-5. Review. Polish.
PMID: 15176310 [PubMed - indexed for MEDLINE]
3
Shattell M, Keltner NL.The case for atypical antipsychotics in
bipolar disorder.
Perspect Psychiatr Care. 2004 Jan-Mar;40(1):34-8. Review.
PMID: 15147051 [PubMed - indexed for MEDLINE]
4
Hori S, Kizu J, Kawamura M.Effects of anti-inflammatory drugs on
convulsant activity of quinolones: a comparative study of drug interaction
between quinolones and anti-inflammatory drugs.
J Infect Chemother. 2003 Dec;9(4):314-20.
PMID: 14691652 [PubMed - indexed for MEDLINE]
5
[No authors listed]Mania induced by antimicrobial agents: mainly
isoniazid, clarithromycin and fluoroquinolones.
Prescrire Int. 2003 Oct;12(67):183. No abstract available.
PMID: 14619905 [PubMed - indexed for MEDLINE]
6
Reeves RR.Gatifloxacin precipitation of psychosis in Alzheimer
disease.
Am J Geriatr Psychiatry. 2003 Jul-Aug;11(4):470-1. No abstract
available.
PMID: 12837678 [PubMed - indexed for MEDLINE]
7
Sumner CL, Elliott RL.Delirium associated with gatifloxacin.
Psychosomatics. 2003 Jan-Feb;44(1):85-6. No abstract available.
PMID: 12515846 [PubMed - indexed for MEDLINE]
8
Kushner JM, Peckman HJ, Snyder CR.Seizures associated with
fluoroquinolones.
Ann Pharmacother. 2001 Oct;35(10):1194-8. Review.
PMID: 11675843 [PubMed - indexed for MEDLINE]
9
Melvani S, Speed BR.Alatrofloxacin-induced seizures during slow
intravenous infusion.
Ann Pharmacother. 2000 Sep;34(9):1017-9.
PMID: 10981247 [PubMed - indexed for MEDLINE]
10
Kundu AK.Norfloxacin-induced hallucination--an unusual CNS toxicity
of 4-fluoroquinolones.
J Assoc Physicians India. 2000 Sep;48(9):944. No abstract
available.
PMID: 11198813 [PubMed - indexed for MEDLINE]
11
Hori S.[A study on the mechanism of seizures associated with the drug
interaction between quinolones and anti-inflammatory drugs. A comparative study
and the structure-activity relationship of anti-inflammatory drugs]
Jpn J Antibiot. 2000 Apr;53(4):249-52. Japanese. No abstract
available.
PMID: 10868302 [PubMed - indexed for MEDLINE]
12
Mangalvedhekar SS, Gogtay NJ, Wagh VR, Waran MS, Mane D, Kshirsagar NA.Convulsions
in non-epileptics due to mefloquine-fluoroquinolone co-administration.
Natl Med J India. 2000 Jan-Feb;13(1):47. No abstract available.
PMID: 10743379 [PubMed - indexed for MEDLINE]
13
Farooq S, Khawaja MY.Fever and acute brief psychosis in developing
countries.
Br J Psychiatry. 1999 Dec;175:586. No abstract available.
PMID: 10789362 [PubMed - indexed for MEDLINE]
14
Jick SS, Vasilakis C, Martinez C, Jick H.A study of the relation of
exposure to quinolones and suicidal behaviour.
Br J Clin Pharmacol. 1998 Jan;45(1):77-81.
PMID: 9489598 [PubMed - indexed for MEDLINE]
15
Walton GD, Hon JK, Mulpur TG.Ofloxacin-induced seizure.
Ann Pharmacother. 1997 Dec;31(12):1475-7.
PMID: 9416384 [PubMed - indexed for MEDLINE]
16
Shiosaki K, Asin KE, Britton DR, Giardina WJ, Bednarz L, Mahan L, Mikusa J,
Nikkel A, Wismer C.Hyperactivity and behavioral seizures in rodents
following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Eur J Pharmacol. 1996 Dec 19;317(2-3):183-90.
PMID: 8997599 [PubMed - indexed for MEDLINE]
17
Feinberg SS.Fluoroquinolone-induced depression.
Am J Psychiatry. 1995 Jun;152(6):954-5. No abstract available.
PMID: 7755134 [PubMed - indexed for MEDLINE]
18
Ross DL, Riley CM.Dissociation and complexation of the
fluoroquinolone antimicrobials--an update.
J Pharm Biomed Anal. 1994 Oct;12(10):1325-31. Review. No
abstract available.
PMID: 7841230 [PubMed - indexed for MEDLINE]
19
Salm EF, Egberts AC, Maartense E, Hart W, Stricker BH.[Psychotic
reactions during administration of quinolones]
Ned Tijdschr Geneeskd. 1994 May 21;138(21):1080-2. Dutch.
PMID: 8202181 [PubMed - indexed for MEDLINE]
20
De Sarro A, Zappala M, Chimirri A, Grasso S, De Sarro GB.Quinolones
potentiate cefazolin-induced seizures in DBA/2 mice.
Antimicrob Agents Chemother. 1993 Jul;37(7):1497-503.
PMID: 8395790 [PubMed - indexed for MEDLINE]
21
Reeves RR.Ciprofloxacin-induced psychosis.
Ann Pharmacother. 1992 Jul-Aug;26(7-8):930-1.
PMID: 1504404 [PubMed - indexed for MEDLINE]
22
Rampa S, Caroli F.[Neuropsychiatric manifestations and
quinolones. Apropos of a case]
Encephale. 1991 Nov-Dec;17(6):511-4. French.
PMID: 1666873 [PubMed - indexed for MEDLINE]
23
Motomura M, Kataoka Y, Takeo G, Shibayama K, Ohishi K, Nakamura T, Niwa M,
Tsujihata M, Nagataki S.Hippocampus and frontal cortex
are the potential mediatory sites for convulsions induced by new quinolones and
non-steroidal anti-inflammatory drugs.
Int J Clin Pharmacol Ther Toxicol. 1991 Jun;29(6):223-7.
PMID: 1651287 [PubMed - indexed for MEDLINE]
24
Defoin JF, Debonne T, Rambourg MO, Seraphin J, Buffet M, Jaussaud M, Bertault R,
Fay R, Digeon B.[Acute psychiatric syndrome and
quinolones]
J Toxicol Clin Exp. 1990 Nov-Dec;10(7-8):469-72. French.
PMID: 2135062 [PubMed - indexed for MEDLINE]
25. Levofloxacin-induced delirium: Diagnostic considerations.
Fernandez-Torre JL.
Clin Neurol Neurosurg. 2006 Sep;108(6):614. Epub 2005 Apr 15. No abstract
available.
Nuerological (25)
1
Murray CK, Wortmann GW.Trovafloxacin-induced weakness due to a
demyelinating polyneuropathy.
South Med J. 2000 May;93(5):514-5.
PMID: 10832955 [PubMed - indexed for MEDLINE]
2 Kim MK, Nightingale C, Nicolau D.
Influence of sex on the pharmacokinetic interaction of fleroxacin and ciprofloxacin with caffeine.
3
Sieb JP.Fluoroquinolone antibiotics block neuromuscular transmission.
Neurology. 1998 Mar;50(3):804-7.
PMID: 9521283 [PubMed - indexed for MEDLINE]
4
Carbo M, Segura J, De la Torre R, Badenas JM, Cami J.Effect
of quinolones on caffeine disposition.
Clin Pharmacol Ther. 1989 Mar;45(3):234-40.
PMID: 2920498 [PubMed - indexed for MEDLINE]
5
Galland MC, Jouve-Bestagne MH, Rodor F, Jouglard J.Neurologic
side effects of quinolones]
Therapie. 1982 Jul-Aug;37(4):481-7. French. No abstract
available.
PMID: 7135332 [PubMed - indexed for MEDLINE]
6
Harder S, Fuhr U, Staib AH, Wolff T.Ciprofloxacin-caffeine:
a drug interaction established using in vivo and in vitro investigations.
Am J Med. 1989 Nov 30;87(5A):89S-91S.
PMID: 2589393 [PubMed - indexed for MEDLINE]
7
Bowie WR, Willetts V, Jewesson PJ.Adverse reactions in
a dose-ranging study with a new long-acting fluoroquinolone, fleroxacin.
Antimicrob Agents Chemother. 1989 Oct;33(10):1778-82.
PMID: 2511802 [PubMed - indexed for MEDLINE]Adverse
reactions developed in 66 (84%) of 79 individuals, and severe reactions arose in
38 (48%). Most frequent were central nervous system reactions (70%), with
insomnia being especially frequent (49%); gastrointestinal reactions (39%) and
photosensitivity reactions (10%) were also common
8
Stille W, Harder S, Mieke S, Beer C, Shah PM, Frech K, Staib AH.Decrease
of caffeine elimination in man during co-administration of 4-quinolones.
J Antimicrob Chemother. 1987 Nov;20(5):729-34.
PMID: 3480885 [PubMed - indexed for MEDLINE]
9
Staib AH, Stille W, Dietlein G, Shah PM, Harder S, Mieke S, Beer C.Interaction
between quinolones and caffeine.
Drugs. 1987;34 Suppl 1:170-4.
PMID: 3481318 [PubMed - indexed for MEDLINE]
10 Kaneda M, Tsuda J, Iida N, Igarashi T, Tajima H, Kizu J, Hori S.
[Surveillance on concurrent administration of quinolones and anti-inflammatory drugs in a community hospital]
11
Aoun M, Jacquy C, Debusscher L, Bron D, Lehert M, Noel P, van der Auwera P.Peripheral
neuropathy associated with fluoroquinolones.
Lancet. 1992 Jul 11;340(8811):127. No abstract available.
PMID: 1352007 [PubMed - indexed for MEDLINE]
12
Giardina WJ.Assessment of temafloxacin neurotoxicity
in rodents.
Am J Med. 1991 Dec 30;91(6A):42S-44S.
PMID: 1662895 [PubMed - indexed for MEDLINE]
13
Thomas RJ, Reagan DR.Association of a Tourette-like syndrome with
ofloxacin.
Ann Pharmacother. 1996 Feb;30(2):138-41.
PMID: 8835045 [PubMed - indexed for MEDLINE]
14
Mahr G, Sorgel F, Granneman GR, Kinzig M, Muth P, Patterson K, Fuhr U, Nickel P,
Stephan U.Effects of temafloxacin and ciprofloxacin on
the pharmacokinetics of caffeine.
Clin Pharmacokinet. 1992;22 Suppl 1:90-7.
PMID: 1319876 [PubMed - indexed for MEDLINE]
15
Stoppe G, Ruther E.[Central nervous system side
effects of different antibacterial substances]
Infection. 1991;19 Suppl 1:S29-32. Review. German.
PMID: 2007512 [PubMed - indexed for MEDLINE]
16
Christ W.Central nervous system toxicity of
quinolones: human and animal findings.
J Antimicrob Chemother. 1990 Oct;26 Suppl B:219-25.
PMID: 2124211 [PubMed - indexed for MEDLINE]
17
Hedenmalm K, Spigset O.Peripheral sensory disturbances related to
treatment with fluoroquinolones.
J Antimicrob Chemother. 1996 Apr;37(4):831-7.
PMID: 8722551 [PubMed - indexed for MEDLINE]
18
Thomas RJ.Neurotoxicity of antibacterial therapy.
South Med J. 1994 Sep;87(9):869-74. Review.
PMID: 8091248 [PubMed - indexed for MEDLINE]
19 Menzies D, Klein NC, Cunha BA.
Trovafloxacin neurotoxicity.
20
Hori S, Kageyama S.Quinolones and their central nervous system
toxicities]
Ryoikibetsu Shokogun Shirizu. 1999;(27 Pt 2):552-7. Review.
Japanese. No abstract available.
PMID: 10434720 [PubMed - indexed for MEDLINE]
21
Guiol C, Ledoussal C, Surge JM.Pharmacological
properties of a new fluoroquinolone on the central nervous system in rodents.
Arzneimittelforschung. 1993 Jan;43(1):56-60.
PMID: 8447850 [PubMed - indexed for MEDLINE]
22
Ichikawa N, Naora K, Hayashibara M, Katagiri Y, Iwamoto K.Effect
of fenbufen on the entry of new quinolones, norfloxacin and ofloxacin, into the
central nervous system in rats.
J Pharm Pharmacol. 1992 Nov;44(11):915-20.
PMID: 1361537 [PubMed - indexed for MEDLINE]
23
Tillotson GS.Comment: peripheral neuropathy syndrome and
fluoroquinolones.
Ann Pharmacother. 2001 Dec;35(12):1673-4. No abstract available.
PMID: 11793644 [PubMed - indexed for MEDLINE]
24
Cohen JS.Peripheral neuropathy associated with fluoroquinolones.
Ann Pharmacother. 2001 Dec;35(12):1540-7.
PMID: 11793615 [PubMed - indexed for MEDLINE]
25
Thiel R, Metzner S, Gericke C, Rahm U, Stahlmann R.Effects of
fluoroquinolones on the locomotor activity in rats.
Arch Toxicol. 2001 Mar;75(1):36-41.
PMID: 11357519 [PubMed - indexed for MEDLINE]
26.
Schmuck G, Schurmann A, Schluter G.
Determination of the excitatory potencies of fluoroquinolones in the
central nervous system by an in vitro model.
Antimicrob Agents Chemother. 1998 Jul;42(7):1831-6.
Erratum in: Antimicrob Agents Chemother 1998 Sep;42(9):2465.
PMID: 9661029 [PubMed - indexed for MEDLINE]
(article in which Bayer admits CNS adverse reactions)
Additional Resources
http://www.remcomp.fr/asmanet/bira-95.html
http://www.urmc.rochester.edu/gebs/faculty/john_Hansen.htm
http://www.sobs.soton.ac.uk/staff/hp.html
http://www.soton.ac.uk/~cig/
http://www.dartmouth.edu/dms/mdphd/cairn_fall99/section3.html