The Fluoroquinolone Toxicity Research Foundation

 
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Levofloxacin's metabolism, excretion, and in vitro plasma protein binding, together with its pharmacokinetics, were studied in the Rhesus monkey in support of an anthrax efficacy study in this species.

Effect of norfloxacin, a new quinolone, on GABA modulation of TRH-induced TSH release from perifused rat pituitaries.

Acute oral toxicity of the new quinolone antibacterial agent levofloxacin in mice, rats and monkeys.
Kato M, Furuhama K, Yoshida M, Akahane K, Takayama S.
Drug Safety Research Center, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.

Arzneimittelforschung. 1992 Mar;43(3A):408-18. General pharmacology of the new quinolone antibacterial agent levofloxacin.
Takasuna K, Kasai Y, Usui C, Takahashi M, Hirohashi M, Tamura K, Takayama S.
Drug Safety Research Center, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.

Individuals with a history of hypersensitivity to quinolones {fluoroquinolones} should avoid exposure to this product {poultry and meat treated with fluoroquinolones}."

Tendon Rupture associated with fluoroquinolones / Animals Studies

Damage to mitochondrial DNA induced by the quinolone (Bay y 3118)  in embryonic turkey liver.

4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells.

Acute oral toxicity of the new quinolone antibacterial agent levofloxacin in mice, rats and monkeys.

Acute oral toxicity of the new quinolone antibacterial agent levofloxacin in mice, rats and monkeys. Kato M, Furuhama K, Yoshida M, Akahane K, Takayama S. Drug Safety Research Center, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.