1990

Histologic and Histochemical Changes in Articular Cartilages of Immature Beagle Dogs Dosed with Difloxacin, a Fluoroquinolone

J.E. Kurkhardt et al (Vet Pathol 27;162-170, 1990)

1995

Magnesium Deficiency Induces Joint Cartilage Lesions in Juvenile Rats which are Identical to Quinolone Induced Arthropathy

Stahlmann et al (Antimicrobial Agents and Chemotherapy, Sept., 1995 pg 2013-2018)

1996

Quinolone induced cartilage lesions are not reversible in rats

Forster et al (Arch Toxicol (1996) 70; 474-481)

1997

Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats

Yoko Kashida et al (Toxicologic Pathology vol 25 number 6 pages 635-643 1997)

2000

Evaluation of toxicokinetic variables and arthropathic changes in juvenile rabbits after oral administration of an ivestigational fluoroquinolone, pd 117596

Johnson et al (AJVR vol 61 no 11, pages, 1396-1402, November 2000)

Human Studies

1972

Nalidixic Acid arthralgia

Bailey et al (CMA Journal 1972; 107 601-605)

1976

Jouirland JP Les ruptures tendineusues. Le tendon normal et patholoqique

Seminar de Monte Carlo 13-14 February 1976

1983

Norfloxacin induced rheumatic disease

Bailey et al (NZ Med J 1983; 96; 590)

1985

Between 1985 and July 1992 100 cases of tendon disorders had been identified in France

Kessler et al (HRG Publication 1399, August 1. 1996)

1987

Ciprofloxacin an update on clinical experience

Areieri et al (Am J of Med 1987 82 381-386)

1988

Adverse effects of fluoroquinolones

Halkin et al (Rev Infect Dis 1988 10 258-261)

1988

Ciprofloxacin and tenosynovitis

McEwan et al ( Lancet 1988 15 900)

1989

Adverse reactions during clinical trials and post marketing surveillance

Janknegt et al (Pharm Weekbl Sci 1989 11(4) 124-127)

1989

Arthritis induced by norfloxacin

Jeandel et al (J Rheumatol 1989 16 560-561)

1991

Rheumatolgical side effects of quinolones

Ribard et al (Baillere’s Clin Rheumatol 1991 5 175-191)

1992

Seven Achilles tendinitis including three complicated by rupture during fluoroquinolone therapy

Ribard et al (J Rheumatol 1992; 19; 1479-1481)

1993

Spontaneous bilateral rupture of the Achille’s tendon in a renal transplant recipient

Mainard et al (Nephron 1993;65- 491-492)

1994

Achilles tenditinis and tendon rupture due to fluoroquinolone therapy

Huston et al (New England Journal of Medicene 1994 331 748)

1994

Features of tendon disorders with fluoroquinolones

Royer et al (Therapie 1994 49 75-76)

1995 Norfloxacin induced arthalgia

Terry et al ( J Rheumatol 1995 22 793-794)

1995

Fluoroquinolone Induced Tenosynovitis of the Wrist mimicking de Quervain’s Disease

Gillet et al (British Journal of Rheumatology vol 34 no 6 pg 583-584, Feb 1995)

1996

Therapie 1996; 51: 419-420 Tendon disorders with fluoroquinolones 421 cases have been collected by the Centre de Pharmacovigilance, 340 of tendinitis and 81 cases of tendon rupture.

1996

Fluoroquinolone induced arthralgia and Magnetic Resonance Imaging

Loeuille et al (The Journal of Rheumatology volume 23 no 7 , July 1996)

1996

Fluoroquinolone Induced Tendinopathy; Report of Six Cases

Zabraniedkl et al (The Journal of Rhuematology 1996; 23; 3)

1997

Tendons and Fluoroquinolones; Unresolved issues

Kahn et al (Rev Rhum [Engl. Ed.] 1997 64(7-9) 437-439)

(Rev Rhum [Ed. Fr.] 1997 64(7-9) 511-513

1997

Fluoroquinolones tendinitis update Australia

Tendinitis associated with Fluoroquinolone therapy

(Pharmaceuticals Newsletters Nos 7&8 July & August 1997)

1997

Tendinitis and tendon rupture with fluoroquinolones

ADRAC (The Achilles heel of fluoroquinolones Aust Adv Drug React Bull 1997;16;7, Szarfman et al)

1997

Effects of Ciprofloxacin and Ofloxacin on adult human cartilage in vitro

(Antimicrob Agents Chemother 1997, Vol 41; issue 11; pages 2562-2565)

1997

Repeated rupture of the extensor tendons of the hand due to fluoroquinolones, Apropos of a case

Levadoux et al (Ann Chir Main Memb Super 1997, vol 16, issue 2, pgs 130-133)

1999

Inhibition of fibroblast metabolism by a fluoroquinolone antibiotic

Williams et al (American Academy of Orthopedic Surgeons, 1999 Annual meeting, paper number 118, Geb 5, 1999)

1999

Fluoroquinolone induced tendinopathy; also occurring with levofloxacin

Fleisch et al (Infection 28 2000 no 4 pages 256-257)

1999

Levofloxacin induced bilateral achilles tendinitis

Lewis et al (The Annals of Pharmacotherapy 1999 July/August, volume 33 pages 792-795)

1999

Fluoroquinolone induced tendinopathy; what do we know?

Harrell et al (South Med J 92(6) 622-625 1999)

2000

Quinolone and Tendon Ruptures

Casperian et al (Southern Medical Journal May 2000 vol 93 no 5 pages 488-491)

2001

Adverse reactions to fluoroquinolones an overview on mechanistic aspects

De Sarro et al (Current Medicinal Chemistry 2001, 8, 371-384)

2001

Fluoroquinolone use and the change in incidence of tendon rupture in the Netherlands

Van der Linden et al (Pharmacy World and Science vol 23 no 3 2001 pg 89-92)

2001

Tendon disorders attributed to fluoroquinolones; a study on 42 spontaneous reports in the period 1988-1998

Van Der Linden et al (American College of Rheumatology; Arthritis Care and Research 45; 2001 pages 235-239)