This is not a complete list of all the fluoroquinolones currently in use today.  The number of fluoroquinolones including generic equivalents is well into the thousands, with various manufacturers using their own trademark names for the very same drug.  The following is a list of the various chemical names that make up this chemotherapeutic class of drugs.  Again this is far from being an exhaustive list of such agents as new drugs are being developed all over the world:

Fluoroquinolones are a group of synthetic antibiotics that are derived from basic structure of nalidixic acid and have substituents at N-1, C-5, C-7, position 8 and a fluorine atom at position 6. There are also polycyclic derivatives. Quinolone antibiotics have a ketone at position 4 and a carboxylic group at position 3. Fluoroquinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, resulting the inhibition of DNA replication and transcription. Fluorine at position 6 enhances gyrase inhibition and cell penetration. Piperaziny substituents provide activity against Gram-negative bacteria and pyrrolidinyl moiety is active against Gram-positive cocci. They improve water solubility needed oral application. The function substituted at position 8 IS to control anaerobe activity.


Fluoroquinolone Substituted at N-1

    Alumofloxacin   No information available
    Amifloxacin
    Balofloxacin
    Ciprofloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Difloxacin       Veterinarian use no further information available
    Ecenofloxacin   Chemos GmbH No information available
    Enoxacin   
    Fleroxacin  Not available for clinical use in several European countries and the USA.
    Gemifloxacin  Still in use in spite of disfiguring rashes
    Grepafloxacin  Removed from Clinical Use due to heart problems
    Lomefloxacin  Still in use in spite of irreversible peripheral neuropathy / tendon ruptures
    Moxifloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures  
    Norfloxacin
    Temafloxacin  Removed from Clinical Use
    Trovafloxacin  Removed from Clinical Use due to fatal liver failures


Substituted at C-5

    Grepafloxacin  Removed from Clinical Use due to heart problems
    Sparfloxacin  Associated with rhabdomyolysis


Substituted at C-7

    Balofloxacin
    Clinafloxacin  Removed from Clinical Use due to severe phototoxicity and hypoglycemia
    Ciprofloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Danafloxacin  Veterinarian use no further information available
    Fleroxacin  Not available for clinical use in several European countries and the USA.
    Garenoxacin Schering
    Gatifloxacin  No longer being manufactured due to severe and fatal hypo/hyperglycemia
    Grepafloxacin  Removed from Clinical Use due to fatal reactions, heart problems
    Irloxacin 
    Levofloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Lomefloxacin  Still in use in spite of irreversible peripheral neuropathy / tendon ruptures
    Moxifloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Nadifloxacin   
    Norfloxacin
    Ofloxacin  Discontinued no reason given
    Piperidiny
    Sitafloxacin    
    Sparfloxacin  Associated with rhabdomyolysis
    Trovafloxacin  Removed from Clinical Use due to fatal liver problems


Substituted at position 8

    Alatrofloxacin (TROVAN) Still in use in spite of fatal liver problems
    Balofloxacin
    Ciprofloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Clinafloxacin  Removed from Clinical Use due to severe phototoxicity and hypoglycemia
    Ecenofloxacin  No information available
    Enoxacin
    Fleroxacin  Not available for clinical use in several European countries and the USA.
    Garenoxacin
    Gatifloxacin  No longer being manufactured due to severe and fatal hypo/hyperglycemia
    Gemifloxacin  Still in use in spite of disfiguring rashes
    Grepafloxacin  Removed from Clinical Use due to heart problems
    Lomefloxacin  Still in use in spite of irreversible peripheral neuropathy / tendon ruptures
    Moxifloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Norfloxacin
    Pazufloxacin   
    Pefloxacin      Not available in USA, Not FDA approved 
    Sitafloxacin    
    Sparfloxacin  Associated with rhabdomyolysis
    Temafloxacin  Removed from Clinical Use
    Tosufloxacin   Associated with chronic interstitial nephritis 
    Trovafloxacin  Removed from Clinical Use due to fatal liver problems
  

Tricyclic derivatives

    Abufloxacin     
    Droxacin         
    Flumequine  Still in use in spite of being direct acting genotoxic carcinogen
    Levofloxacin  Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Marbofloxacin
    Miloxacin 
    Ofloxacin  Discontinued no reason given
    Oxolinic acid   
    Pazufloxacin   
    Prulifloxacin    
    Rufloxacin      
    Verbafloxacin 
 

QUINOLONES (Non-fluorinated)

    Cinoxacin 28657-80-9  Discontinued no reason given
    Mictral 79449-95-9  
    Miloxacin 37065-29-5  
    Nalidixic acid 389-08-2  Discontinued cancer causing agent
    Nalidixate sodium anhydrous 3374-05-8
    Nalidixate sodium 15769-77-4             
    Oxolinic acid 14698-29-4             
    Pipemidic acid 51940-44-4         
    Piromidic acid 19562-30-2        
    Rosoxacin 40034-42-2   Usage restricted to gonorrhea        
   

FLUOROQUINOLONES (fluorinated)

    Alatrofloxacin 157182-32-6   
    Amifloxacin   86393-37-5 
    Balofloxacin 127294-70-6   
    Ciprofloxacin 85721-33-1 Still in use in spite of fatal reactions, peripheral neuropathy / tendon ruptures
    Clinafloxacin 105956-97-6  Removed from Clinical Use due to severe phototoxicity and hypoglycemia
    Danofloxacin 112398-08-0   Veterinarian use no further information available      
    Difloxacin 98106-17-3      Veterinarian use no further information available 
    Ecenofloxacin 162301-05-5  No information available
    Enoxacin 74011-58-8  
    Enrofloxacin 93106-60-6  Banned by the FDA    
    Fleroxacin 79660-72-3  Not available for clinical use in several European countries and the USA. 
    Flumequine 42835-25-6  Still in use in spite of being direct acting genotoxic carcinogen        
    Gatifloxacin 112811-59-3   No longer being manufactured due to severe and fatal hypo/hyperglycemia
    Gemifloxacin 175463-14-6  Still in use in spite of disfiguring rashes   
    Grepafloxacin 119914-60-2  Removed from Clinical Use due to fatal heart problems
    Levofloxacin 100986-85-4  Still in use: fatal reactions, peripheral neuropathy / tendon ruptures
    Lomefloxacin 98079-51-7   Still in use in spite of peripheral neuropathy / tendon ruptures
    Marbofloxacin 115550-35-1
    Moxifloxacin 151096-09-2  Still in use: fatal reactions, peripheral neuropathy / tendon ruptures
    Nadifloxacin 124858-35-1          
    Norfloxacin 70458-96-7 
    Ofloxacin 82419-36-1  No longer being manufactured no reason given
    Orbifloxacin 113617-63-3 
    Pazufloxacin 127045-41-4
    Pefloxacin 70458-92-3      Not available in USA, Not FDA approved           
    Prulifloxacin 123447-62-1  Optimer
    Rufloxacin 101363-10-4 
    Sarafloxacin 98105-99-8    
    Sitafloxacin 127254-12-0        
    Sparfloxacin 110871-86-8  Associated with rhabdomyolysis
    Temafloxacin 108319-06-8  Removed from Clinical Use 
    Tosufloxacin 100490-36-6   Associated with chronic interstitial nephritis    
    Trovafloxacin 147059-72-1  Removed from Clinical Use due to fatal liver problems

** Note:  Lack of information found on the FDA site may be for several reasons including
   the drug being removed from clinical practice, different name, or veterinarian use.